Gene description for RYR2
Gene name	ryanodine receptor 2 (cardiac)
Gene symbol	RYR2
Other names/aliases	ARVC2 ARVD2 RYR-2 RyR VTSIP
Species	Homo sapiens
Database cross references - RYR2
ExoCarta	ExoCarta_6262
Entrez Gene	6262
HGNC	10484
MIM	180902
UniProt	Q92736
RYR2 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells	25944692

Gene ontology annotations for RYR2

Molecular Function     calmodulin binding GO:0005516 ISS     calcium-release channel activity GO:0015278 IDA     enzyme binding GO:0019899 IPI     intracellular ligand-gated calcium channel activity GO:0005218 ISS     ryanodine-sensitive calcium-release channel activity GO:0005219 IDA     ion channel binding GO:0044325 ISS     suramin binding GO:0043924 IMP     calcium channel activity GO:0005262 ISS     protein kinase A regulatory subunit binding GO:0034237 IDA     identical protein binding GO:0042802 IPI     protein binding GO:0005515 IPI     protein self-association GO:0043621 IEA     calcium ion binding GO:0005509 IEA     calcium-induced calcium release activity GO:0048763 IDA     protein kinase A catalytic subunit binding GO:0034236 IDA Biological Process     regulation of cardiac muscle contraction GO:0055117 IMP     regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion GO:0010881 ISS     regulation of AV node cell action potential GO:0098904 IMP     cellular response to epinephrine stimulus GO:0071872 TAS     response to muscle activity GO:0014850 IMP     positive regulation of ryanodine-sensitive calcium-release channel activity by adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction GO:0086094 IEA     cellular calcium ion homeostasis GO:0006874 ISS     canonical Wnt signaling pathway GO:0060070 IEA     response to hypoxia GO:0001666 ISS     response to caffeine GO:0031000 IDA     release of sequestered calcium ion into cytosol GO:0051209 ISS     ventricular cardiac muscle cell action potential GO:0086005 ISS     positive regulation of heart rate GO:0010460 ISS     positive regulation of the force of heart contraction GO:0098735 IMP     type B pancreatic cell apoptotic process GO:0097050 IMP     regulation of cardiac muscle contraction by calcium ion signaling GO:0010882 IMP     sarcoplasmic reticulum calcium ion transport GO:0070296 TAS     calcium-mediated signaling using intracellular calcium source GO:0035584 IDA     embryonic heart tube morphogenesis GO:0003143 ISS     cell communication by electrical coupling involved in cardiac conduction GO:0086064 IC     regulation of heart rate GO:0002027 IMP     cardiac muscle contraction GO:0060048 IMP     positive regulation of sequestering of calcium ion GO:0051284 IDA     response to muscle stretch GO:0035994 IMP     regulation of atrial cardiac muscle cell action potential GO:0098910 IMP     Purkinje myocyte to ventricular cardiac muscle cell signaling GO:0086029 ISS     calcium ion transmembrane transport GO:0070588 IEA     detection of calcium ion GO:0005513 IDA     regulation of ventricular cardiac muscle cell action potential GO:0098911 IMP     regulation of SA node cell action potential GO:0098907 IMP     cellular response to caffeine GO:0071313 ISS     establishment of protein localization to endoplasmic reticulum GO:0072599 IDA     BMP signaling pathway GO:0030509 IEA     response to redox state GO:0051775 IDA     cytosolic calcium ion homeostasis GO:0051480 ISS     cardiac muscle hypertrophy GO:0003300 ISS     ion transmembrane transport GO:0034220 TAS     left ventricular cardiac muscle tissue morphogenesis GO:0003220 ISS     calcium ion transport GO:0006816 IDA     calcium-mediated signaling GO:0019722 ISS     positive regulation of calcium-transporting ATPase activity GO:1901896 IDA     transmembrane transport GO:0055085 TAS     release of sequestered calcium ion into cytosol by sarcoplasmic reticulum GO:0014808 ISS     calcium ion transport into cytosol GO:0060402 IDA Subcellular Localization     cytosol GO:0005829 ISS     extracellular exosome GO:0070062 IDA     sarcoplasmic reticulum GO:0016529 IDA     Z disc GO:0030018 ISS     plasma membrane GO:0005886 ISS     smooth endoplasmic reticulum GO:0005790 IEA     junctional sarcoplasmic reticulum membrane GO:0014701 TAS     calcium channel complex GO:0034704 IDA     protein complex GO:0043234 IDA     membrane GO:0016020 IDA     sarcoplasmic reticulum membrane GO:0033017 TAS