Gene description for SNTA1
Gene name syntrophin, alpha 1
Gene symbol SNTA1
Other names/aliases LQT12
Species Homo sapiens
 Database cross references - SNTA1
ExoCarta ExoCarta_6640
Entrez Gene 6640
HGNC 11167
MIM 601017
UniProt Q13424  
 SNTA1 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for SNTA1
Molecular Function
    protein binding GO:0005515 IPI
    ATPase binding GO:0051117 IPI
    actin binding GO:0003779 IEA
    nitric-oxide synthase binding GO:0050998 IPI
    PDZ domain binding GO:0030165 IEA
    sodium channel regulator activity GO:0017080 IMP
    calmodulin binding GO:0005516 IEA
    ion channel binding GO:0044325 IPI
Biological Process
    ventricular cardiac muscle cell action potential GO:0086005 IMP
    muscle contraction GO:0006936 TAS
    regulation of sodium ion transmembrane transport GO:1902305 IMP
    neuromuscular junction development GO:0007528 IEA
    regulation of ventricular cardiac muscle cell membrane repolarization GO:0060307 IMP
    regulation of vasoconstriction by circulating norepinephrine GO:0003117 IEA
    negative regulation of peptidyl-cysteine S-nitrosylation GO:1902083 IMP
    regulation of heart rate GO:0002027 IMP
Subcellular Localization
    neuromuscular junction GO:0031594 IEA
    syntrophin complex GO:0016013 TAS
    lateral plasma membrane GO:0016328 TAS
    sarcolemma GO:0042383 IEA
    cytoskeleton GO:0005856 IEA
    cell junction GO:0030054 IEA
    postsynaptic membrane GO:0045211 IEA
    intracellular GO:0005622 IDA
    protein complex GO:0043234 IDA
    cytoplasm GO:0005737 IEA
 Experiment description of studies that identified SNTA1 in exosomes
Experiment ID 236
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name MHCC97L
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for SNTA1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 DTNB  
Affinity Capture-Western Homo sapiens
2 XRCC6 2547
Two-hybrid Homo sapiens
3 SCN4A  
Invivo Homo sapiens
4 GLS 2744
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
5 UTRN 7402
Protein-peptide Homo sapiens
6 DGKZ  
Reconstituted Complex Homo sapiens
7 DTNA  
Invivo Homo sapiens
8 DMD  
Invitro Homo sapiens
Protein-peptide Homo sapiens
9 GRB2 2885
Affinity Capture-Western Homo sapiens
Invivo Homo sapiens
10 KCNJ12 3768
Affinity Capture-MS Homo sapiens
11 SCN5A 6331
Invivo Homo sapiens
12 KCNJ4  
Affinity Capture-Western Homo sapiens
13 NOS1  
Invivo Homo sapiens
14 CALM1 801
Invivo Homo sapiens
View the network image/svg+xml
 Pathways in which SNTA1 is involved
No pathways found

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