Gene description for NDEL1
Gene name nudE neurodevelopment protein 1-like 1
Gene symbol NDEL1
Other names/aliases EOPA
MITAP1
NDE1L1
NDE2
NUDEL
Species Homo sapiens
 Database cross references - NDEL1
ExoCarta ExoCarta_81565
Vesiclepedia VP_81565
Entrez Gene 81565
HGNC 17620
MIM 607538
UniProt Q9GZM8  
 NDEL1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for NDEL1
Molecular Function
    protein binding GO:0005515 IPI
    microtubule binding GO:0008017 IBA
    identical protein binding GO:0042802 IPI
    alpha-tubulin binding GO:0043014 IEA
    beta-tubulin binding GO:0048487 IEA
Biological Process
    establishment of mitotic spindle orientation GO:0000132 IBA
    inner cell mass cell proliferation GO:0001833 IEA
    microtubule nucleation GO:0007020 IBA
    chromosome segregation GO:0007059 IBA
    chromosome segregation GO:0007059 IMP
    mitotic centrosome separation GO:0007100 IBA
    retrograde axonal transport GO:0008090 IEA
    insulin receptor signaling pathway GO:0008286 IEA
    regulation of neuron projection development GO:0010975 IBA
    cell migration GO:0016477 IBA
    cerebral cortex radially oriented cell migration GO:0021799 IEA
    central nervous system neuron axonogenesis GO:0021955 IEA
    lysosome localization GO:0032418 ISS
    regulation of intracellular protein transport GO:0033157 IMP
    positive regulation of GTPase activity GO:0043547 IMP
    vesicle transport along microtubule GO:0047496 IBA
    establishment of chromosome localization GO:0051303 IBA
    centrosome localization GO:0051642 IBA
    neurofilament cytoskeleton organization GO:0060052 IEA
    radial glia-guided pyramidal neuron migration GO:0140650 IEA
    positive regulation of ruffle assembly GO:1900029 ISS
    neuron projection extension GO:1990138 IEA
Subcellular Localization
    kinetochore GO:0000776 IBA
    kinetochore GO:0000776 IDA
    centrosome GO:0005813 IBA
    spindle GO:0005819 IEA
    cytosol GO:0005829 TAS
    kinesin complex GO:0005871 IBA
    microtubule GO:0005874 IEA
    synaptic vesicle GO:0008021 IEA
    cell leading edge GO:0031252 IEA
    axon hillock GO:0043203 IEA
    neurofilament cytoskeleton GO:0060053 IEA
    axon cytoplasm GO:1904115 IEA
 Experiment description of studies that identified NDEL1 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for NDEL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TRAF3IP3  
Two-hybrid Homo sapiens
2 CCSER2 54462
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
3 ZNF211  
Two-hybrid Homo sapiens
4 MLLT10  
Two-hybrid Homo sapiens
5 ANK2 287
Two-hybrid Homo sapiens
6 CCDC18  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 KIFC3 3801
Two-hybrid Homo sapiens
8 PKP2 5318
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
9 CCSER1  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 CEP55 55165
Two-hybrid Homo sapiens
11 PTX3 5806
Affinity Capture-MS Homo sapiens
12 RPA2 6118
Two-hybrid Homo sapiens
13 CCDC183  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 DYNC1I1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
15 XPA  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
16 GRIPAP1 56850
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 DCTN2 10540
Affinity Capture-Western Homo sapiens
18 FBXW5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 SNX6 58533
Two-hybrid Homo sapiens
20 ZNF662  
Two-hybrid Homo sapiens
21 APP 351
Reconstituted Complex Homo sapiens
22 ABI3 51225
Two-hybrid Homo sapiens
23 ZNF3  
Two-hybrid Homo sapiens
24 UTRN 7402
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 RPS6KA3 6197
Affinity Capture-MS Homo sapiens
26 ZNF230  
Two-hybrid Homo sapiens
27 MBIP  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
28 NDE1 54820
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
29 SCARA3  
Affinity Capture-MS Homo sapiens
30 TRIOBP 11078
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
31 PRC1 9055
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
32 KRT40  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
33 ZNF197  
Two-hybrid Homo sapiens
34 YWHAG 7532
Two-hybrid Homo sapiens
35 OBSL1 23363
Affinity Capture-MS Homo sapiens
36 MTUS2 23281
Two-hybrid Homo sapiens
37 ZNF844  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
38 KTN1 3895
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 DYNLL1 8655
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
40 TULP3 7289
Affinity Capture-MS Homo sapiens
41 KATNB1  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
42 ZNF35  
Two-hybrid Homo sapiens
43 PTPN14 5784
Affinity Capture-MS Homo sapiens
44 USP2  
Two-hybrid Homo sapiens
45 Ccser2  
Affinity Capture-MS Mus musculus
46 AP4E1  
Affinity Capture-MS Homo sapiens
47 RBM14 10432
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
48 CASK 8573
Two-hybrid Homo sapiens
49 MRC2 9902
Two-hybrid Homo sapiens
50 ZNF180  
Two-hybrid Homo sapiens
51 TRIM7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 CDK5 1020
Biochemical Activity Homo sapiens
Co-localization Homo sapiens
53 KLC4 89953
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
54 TUBA1A 7846
Affinity Capture-Western Homo sapiens
55 MAPRE1 22919
Affinity Capture-MS Homo sapiens
56 GOLGA2 2801
Two-hybrid Homo sapiens
57 OFD1 8481
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
58 SNTA1 6640
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 KIF5A 3798
Two-hybrid Homo sapiens
60 SLAIN1 122060
Two-hybrid Homo sapiens
61 YWHAE 7531
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
62 DTNB 1838
Two-hybrid Homo sapiens
63 Pafah1b1 18472
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
64 SYNE1 23345
Two-hybrid Homo sapiens
65 SNAP29 9342
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 LUC7L2 51631
Two-hybrid Homo sapiens
67 ZNF91  
Two-hybrid Homo sapiens
68 ACTB 60
Two-hybrid Homo sapiens
69 DYNLL2 140735
Affinity Capture-MS Homo sapiens
70 ANKRD26 22852
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
71 KIF20B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 AIMP2 7965
Two-hybrid Homo sapiens
73 KIF2C 11004
Two-hybrid Homo sapiens
74 RBM10  
Two-hybrid Homo sapiens
75 DISC1 27185
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 TUBG1 7283
Affinity Capture-Western Homo sapiens
77 RBM5  
Two-hybrid Homo sapiens
78 TUBB 203068
Two-hybrid Homo sapiens
79 SNAPC5  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
80 CEP63  
Two-hybrid Homo sapiens
81 LMNB1 4001
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
82 MAGEA11  
Two-hybrid Homo sapiens
83 AKAP9 10142
Two-hybrid Homo sapiens
84 MIS18A  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
85 ZNF572  
Two-hybrid Homo sapiens
86 MYO5A 4644
Two-hybrid Homo sapiens
87 ZNF250  
Two-hybrid Homo sapiens
88 ZNF707  
Two-hybrid Homo sapiens
89 DIXDC1  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 Nde1  
Affinity Capture-MS Mus musculus
91 EVI5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 ZNF260  
Two-hybrid Homo sapiens
93 PRPF19 27339
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
94 FXR2 9513
Two-hybrid Homo sapiens
95 ZNF544  
Two-hybrid Homo sapiens
96 ZNF12  
Two-hybrid Homo sapiens
97 TRIM27  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
98 NDC80 10403
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
99 KALRN 8997
Two-hybrid Homo sapiens
100 BMI1  
Two-hybrid Homo sapiens
101 CCDC88A 55704
Two-hybrid Homo sapiens
102 ZC2HC1C  
Two-hybrid Homo sapiens
103 CLPX 10845
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 ZNF17  
Two-hybrid Homo sapiens
105 ZNF417  
Two-hybrid Homo sapiens
106 TPM3 7170
Affinity Capture-MS Homo sapiens
107 TACC3  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
108 MED11  
Two-hybrid Homo sapiens
109 IMMT 10989
Two-hybrid Homo sapiens
Far Western Homo sapiens
Reconstituted Complex Homo sapiens
110 PAFAH1B1 5048
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Co-localization Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
111 SLC25A43  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
112 NUP54 53371
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
113 CTR9 9646
Affinity Capture-MS Homo sapiens
114 BCAS2 10286
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
115 KIAA1598 57698
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
116 PARVG 64098
Two-hybrid Homo sapiens
117 ZNF264  
Two-hybrid Homo sapiens
118 PARD6G 84552
Two-hybrid Homo sapiens
119 PAFAH1B2 5049
Affinity Capture-MS Homo sapiens
120 ZNF445  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
121 CCHCR1  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
122 CENPF 1063
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
123 CWF19L2  
Two-hybrid Homo sapiens
124 KATNA1 11104
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
125 ZNF490  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
126 BRK1 55845
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
127 DYNC1H1 1778
Co-fractionation Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
128 KIF19  
Two-hybrid Homo sapiens
129 SNTB1 6641
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
130 CEP135  
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
131 ZNF10  
Two-hybrid Homo sapiens
132 NDEL1 81565
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
133 ZNF599  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
134 MTCL1 23255
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
135 SNTB2 6645
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
136 CEP170 9859
Two-hybrid Homo sapiens
137 C17orf59 54785
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
138 NAP1L5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
139 ARIH1 25820
Affinity Capture-MS Homo sapiens
140 NPTX2  
Affinity Capture-MS Homo sapiens
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