Gene description for NDE1
Gene name nudE neurodevelopment protein 1
Gene symbol NDE1
Other names/aliases HOM-TES-87
LIS4
MHAC
NDE
NUDE
NUDE1
Species Homo sapiens
 Database cross references - NDE1
ExoCarta ExoCarta_54820
Vesiclepedia VP_54820
Entrez Gene 54820
HGNC 17619
MIM 609449
UniProt Q9NXR1  
 NDE1 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
Urine 21595033    
Urine 21595033    
Urine 21595033    
 Gene ontology annotations for NDE1
Molecular Function
    identical protein binding GO:0042802 IEA
    protein domain specific binding GO:0019904 IEA
    microtubule binding GO:0008017 ISS
    protein binding GO:0005515 IPI
Biological Process
    neuron migration GO:0001764 IEA
    organelle organization GO:0006996 TAS
    microtubule nucleation GO:0007020 IBA
    cell division GO:0051301 IEA
    centrosome duplication GO:0051298 ISS
    small GTPase mediated signal transduction GO:0007264 TAS
    establishment of mitotic spindle orientation GO:0000132 IMP
    chromosome segregation GO:0007059 IBA
    centrosome localization GO:0051642 IBA
    mitotic centrosome separation GO:0007100 IBA
    mitotic cell cycle GO:0000278 TAS
    vesicle transport along microtubule GO:0047496 IBA
    cerebral cortex development GO:0021987 IMP
    G2/M transition of mitotic cell cycle GO:0000086 TAS
    neuroblast proliferation GO:0007405 IEA
    establishment of chromosome localization GO:0051303 IMP
    cell migration GO:0016477 IBA
Subcellular Localization
    kinetochore GO:0000776 IDA
    centrosome GO:0005813 IDA
    microtubule GO:0005874 IEA
    cleavage furrow GO:0032154 IEA
    cytosol GO:0005829 TAS
    kinesin complex GO:0005871 IBA
    membrane GO:0016020 IDA
    spindle pole centrosome GO:0031616 ISS
    condensed chromosome kinetochore GO:0000777 IEA
 Experiment description of studies that identified NDE1 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 193
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD63|CD9
EV Enriched markers
✔
PHB
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 194
MISEV standards
✘ EV Biophysical techniques
✘ EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of basement membrane nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 195
MISEV standards
✘ EV Biophysical techniques
✘ EV Enriched markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 21595033    
Organism Homo sapiens
Experiment description Proteomic analysis of urinary exosomes from patients of early IgA nephropathy and thin basement membrane nephropathy.
Authors Moon PG, Lee JE, You S, Kim TK, Cho JH, Kim IS, Kwon TH, Kim CD, Park SH, Hwang D, Kim YL, Baek MC.
Journal name Proteomics
Publication year 2011
Sample Urine
Sample name Urine - Patients of early IgA nephropathy
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for NDE1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PAFAH1B1 5048
Invivo Homo sapiens
Two-hybrid Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
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