Gene description for CLPTM1L
Gene name CLPTM1-like
Gene symbol CLPTM1L
Other names/aliases CRR9
Species Homo sapiens
 Database cross references - CLPTM1L
ExoCarta ExoCarta_81037
Vesiclepedia VP_81037
Entrez Gene 81037
HGNC 24308
MIM 612585
UniProt Q96KA5  
 CLPTM1L identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for CLPTM1L
Molecular Function
    protein binding GO:0005515 IPI
    phospholipid scramblase activity GO:0017128 IDA
Biological Process
    apoptotic process GO:0006915 IEA
    plasma membrane phospholipid scrambling GO:0017121 IEA
Subcellular Localization
    endoplasmic reticulum membrane GO:0005789 IDA
    endomembrane system GO:0012505 IBA
    membrane GO:0016020 HDA
    membrane GO:0016020 IBA
 Experiment description of studies that identified CLPTM1L in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for CLPTM1L
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 EFNA1  
Affinity Capture-MS Homo sapiens
2 ANLN 54443
Affinity Capture-MS Homo sapiens
3 PANX1 24145
Proximity Label-MS Homo sapiens
4 DNAJB11 51726
Proximity Label-MS Homo sapiens
5 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
6 SPTAN1 6709
Co-fractionation Homo sapiens
7 SERBP1 26135
Affinity Capture-MS Homo sapiens
8 Ercc6l  
Affinity Capture-MS Mus musculus
9 VAPB 9217
Affinity Capture-MS Homo sapiens
10 NCSTN 23385
Affinity Capture-MS Homo sapiens
11 COIL  
Proximity Label-MS Homo sapiens
12 CANX 821
Affinity Capture-MS Homo sapiens
13 DNAJB12 54788
Proximity Label-MS Homo sapiens
14 MRPL47 57129
Co-fractionation Homo sapiens
15 CALR3  
Proximity Label-MS Homo sapiens
16 TUBG1 7283
Affinity Capture-MS Homo sapiens
17 GK  
Two-hybrid Homo sapiens
18 HLA-DRA 3122
Affinity Capture-MS Homo sapiens
19 NUP155 9631
Proximity Label-MS Homo sapiens
20 SYNGR1 9145
Affinity Capture-MS Homo sapiens
21 CD1B 910
Affinity Capture-MS Homo sapiens
22 CALU 813
Proximity Label-MS Homo sapiens
23 LRRC59 55379
Proximity Label-MS Homo sapiens
24 EMC7 56851
Affinity Capture-MS Homo sapiens
25 Itgb1 16412
Affinity Capture-MS Mus musculus
26 ADRB2  
Two-hybrid Homo sapiens
27 ARSE 415
Affinity Capture-MS Homo sapiens
28 LMNB1 4001
Proximity Label-MS Homo sapiens
29 NOP56 10528
Proximity Label-MS Homo sapiens
30 PDHA1 5160
Proximity Label-MS Homo sapiens
31 BCAP31 10134
Proximity Label-MS Homo sapiens
32 CUL3 8452
Affinity Capture-MS Homo sapiens
33 NR3C1 2908
Proximity Label-MS Homo sapiens
34 RPA3 6119
Proximity Label-MS Homo sapiens
35 NIPAL1  
Affinity Capture-MS Homo sapiens
36 UNC93B1 81622
Affinity Capture-MS Homo sapiens
37 PARK2  
Affinity Capture-MS Homo sapiens
38 AQP3  
Affinity Capture-MS Homo sapiens
39 PDIA4 9601
Proximity Label-MS Homo sapiens
40 Ppp4c 56420
Affinity Capture-MS Mus musculus
41 NCDN 23154
Affinity Capture-MS Homo sapiens
42 SFTPC  
Affinity Capture-MS Homo sapiens
43 UQCRQ 27089
Co-fractionation Homo sapiens
44 KIAA1429 25962
Affinity Capture-MS Homo sapiens
45 TMEM173  
Affinity Capture-MS Homo sapiens
46 ERGIC2 51290
Proximity Label-MS Homo sapiens
47 MARCH4  
Affinity Capture-MS Homo sapiens
48 E2F4  
Affinity Capture-MS Homo sapiens
49 Kcnk1  
Affinity Capture-MS Mus musculus
50 GPR182  
Affinity Capture-MS Homo sapiens
51 RPA2 6118
Proximity Label-MS Homo sapiens
52 ZBTB33  
Affinity Capture-MS Homo sapiens
53 SPPL2B 56928
Affinity Capture-MS Homo sapiens
54 NTRK1 4914
Affinity Capture-MS Homo sapiens
55 NDE1 54820
Affinity Capture-MS Homo sapiens
56 CIT 11113
Affinity Capture-MS Homo sapiens
57 Ttk  
Affinity Capture-MS Mus musculus
58 RPN1 6184
Proximity Label-MS Homo sapiens
59 AKAP1 8165
Proximity Label-MS Homo sapiens
60 Tnpo1 238799
Affinity Capture-MS Mus musculus
61 DHFRL1  
Proximity Label-MS Homo sapiens
62 VWA8 23078
Proximity Label-MS Homo sapiens
63 DNASE1L1 1774
Affinity Capture-MS Homo sapiens
64 ADGRE5 976
Affinity Capture-MS Homo sapiens
65 VIPR1  
Affinity Capture-MS Homo sapiens
66 ISLR 3671
Affinity Capture-MS Homo sapiens
67 PIK3C3 5289
Affinity Capture-MS Homo sapiens
68 DNAJC30  
Proximity Label-MS Homo sapiens
69 SLC12A6 9990
Affinity Capture-MS Homo sapiens
70 PEX3 8504
Proximity Label-MS Homo sapiens
71 Mib1  
Affinity Capture-MS Mus musculus
72 ATP2A3 489
Affinity Capture-MS Homo sapiens
73 Smn1 20595
Affinity Capture-MS Mus musculus
74 SEC61B 10952
Proximity Label-MS Homo sapiens
75 RPN2 6185
Proximity Label-MS Homo sapiens
76 EXD2  
Proximity Label-MS Homo sapiens
77 CCDC47 57003
Affinity Capture-MS Homo sapiens
78 HLA-C 3107
Affinity Capture-MS Homo sapiens
79 RNF139  
Affinity Capture-MS Homo sapiens
80 ATP2A1 487
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which CLPTM1L is involved
No pathways found





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