Gene description for Ppp4c
Gene name protein phosphatase 4, catalytic subunit
Gene symbol Ppp4c
Other names/aliases 1110002D08Rik
AU016079
Ppx
Species Mus musculus
 Database cross references - Ppp4c
ExoCarta ExoCarta_56420
Entrez Gene 56420
UniProt P97470  
 Ppp4c identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Ppp4c
Molecular Function
    protein binding GO:0005515 IPI
    protein serine/threonine phosphatase activity GO:0004722 NAS
    hydrolase activity GO:0016787 IEA
    protein complex binding GO:0032403 ISO
    metal ion binding GO:0046872 IEA
    phosphatase activity GO:0016791 ISO
    lamin binding GO:0005521 ISO
    NF-kappaB-inducing kinase activity GO:0004704 NAS
    phosphoprotein phosphatase activity GO:0004721 IEA
Biological Process
    dephosphorylation GO:0016311 NAS
    NIK/NF-kappaB signaling GO:0038061 NAS
    signal transduction by protein phosphorylation GO:0023014 NAS
    regulation of double-strand break repair via homologous recombination GO:0010569 ISO
Subcellular Localization
    cytoskeleton GO:0005856 IEA
    protein phosphatase 4 complex GO:0030289 IDA
    nucleoplasm GO:0005654 ISO
    plasma membrane GO:0005886 ISO
    cytoplasm GO:0005737 ISO
    nucleus GO:0005634 ISO
 Experiment description of studies that identified Ppp4c in exosomes
1
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Ppp4c
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Ppp4c is involved
No pathways found





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