Gene description for Ppp4c
Gene name protein phosphatase 4, catalytic subunit
Gene symbol Ppp4c
Other names/aliases 1110002D08Rik
AU016079
Ppx
Species Mus musculus
 Database cross references - Ppp4c
ExoCarta ExoCarta_56420
Vesiclepedia VP_56420
Entrez Gene 56420
UniProt P97470  
 Ppp4c identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Ppp4c
Molecular Function
    protein serine/threonine phosphatase activity GO:0004722 IBA
    protein serine/threonine phosphatase activity GO:0004722 ISO
    protein serine/threonine phosphatase activity GO:0004722 ISS
    protein serine/threonine phosphatase activity GO:0004722 NAS
    protein binding GO:0005515 IPI
    lamin binding GO:0005521 ISO
    phosphatase activity GO:0016791 ISO
    myosin phosphatase activity GO:0017018 IEA
    calmodulin-dependent protein phosphatase activity GO:0033192 IEA
    protein-containing complex binding GO:0044877 ISO
    metal ion binding GO:0046872 IEA
    histone H2AXS140 phosphatase activity GO:0140791 IEA
    RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity GO:0180004 IEA
    RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity GO:0180005 IEA
    RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity GO:0180006 IEA
    RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity GO:0180007 IEA
    RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity GO:0180008 IEA
    MAP kinase serine/threonine phosphatase activity GO:1990439 IEA
Biological Process
    double-strand break repair via homologous recombination GO:0000724 IBA
    negative regulation of protein phosphorylation GO:0001933 ISO
    chromatin remodeling GO:0006338 IEA
    regulation of transcription by RNA polymerase II GO:0006357 IEA
    regulation of double-strand break repair via homologous recombination GO:0010569 ISO
    regulation of double-strand break repair via homologous recombination GO:0010569 ISS
    regulation of double-strand break repair GO:2000779 ISO
Subcellular Localization
    chromatin GO:0000785 ISO
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleus GO:0005634 ISO
    nucleoplasm GO:0005654 IEA
    nucleoplasm GO:0005654 ISO
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    centrosome GO:0005813 IEA
    cytosol GO:0005829 IEA
    cytosol GO:0005829 ISO
    plasma membrane GO:0005886 IEA
    plasma membrane GO:0005886 ISO
    protein phosphatase 4 complex GO:0030289 IDA
    protein phosphatase 4 complex GO:0030289 ISO
 Experiment description of studies that identified Ppp4c in exosomes
1
Experiment ID 15
MISEV standards
EM
Biophysical techniques
CD63
Enriched markers
Negative markers
Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors "Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO"
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Ppp4c
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 IGBP1 3476
Affinity Capture-MS Homo sapiens
2 PPP4R1 9989
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
3 Ppp4r2  
Co-fractionation Mus musculus
4 CCT8 10694
Affinity Capture-MS Homo sapiens
5 CCT3 7203
Affinity Capture-MS Homo sapiens
6 PPP4R2  
Affinity Capture-MS Homo sapiens
7 GAR1 54433
Affinity Capture-MS Homo sapiens
8 SMEK2  
Affinity Capture-MS Homo sapiens
9 XPO1 7514
Affinity Capture-MS Homo sapiens
10 CCT2 10576
Affinity Capture-MS Homo sapiens
11 CCT6A 908
Affinity Capture-MS Homo sapiens
12 TCP1 6950
Affinity Capture-MS Homo sapiens
13 MAGEA1  
Affinity Capture-MS Homo sapiens
14 DNAJA3 9093
Affinity Capture-MS Homo sapiens
15 URB1 9875
Affinity Capture-MS Homo sapiens
16 CCT4 10575
Affinity Capture-MS Homo sapiens
17 NAP1L1 4673
Affinity Capture-MS Homo sapiens
18 CPT1A 1374
Affinity Capture-MS Homo sapiens
19 CCT7 10574
Affinity Capture-MS Homo sapiens
20 CCT5 22948
Affinity Capture-MS Homo sapiens
21 LCOR 84458
Affinity Capture-MS Homo sapiens
22 YME1L1 10730
Affinity Capture-MS Homo sapiens
23 PPP2R1A 5518
Affinity Capture-MS Homo sapiens
24 KLC2 64837
Affinity Capture-MS Homo sapiens
25 RREB1 6239
Affinity Capture-MS Homo sapiens
26 BANF1 8815
Affinity Capture-MS Homo sapiens
27 CLPTM1L 81037
Affinity Capture-MS Homo sapiens
28 NARF 26502
Affinity Capture-MS Homo sapiens
29 MAGED2 10916
Affinity Capture-MS Homo sapiens
30 CCDC6 8030
Affinity Capture-MS Homo sapiens
31 NOP10 55505
Affinity Capture-MS Homo sapiens
32 SMEK1 55671
Affinity Capture-MS Homo sapiens
33 Tiprl  
Co-fractionation Mus musculus
View the network image/svg+xml



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