Gene description for LCOR
Gene name ligand dependent nuclear receptor corepressor
Gene symbol LCOR
Other names/aliases MLR2
Species Homo sapiens
 Database cross references - LCOR
ExoCarta ExoCarta_84458
Entrez Gene 84458
HGNC 29503
MIM 607698
UniProt Q96JN0  
 LCOR identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for LCOR
Molecular Function
    sequence-specific DNA binding transcription factor activity GO:0003700 IEA
    DNA binding GO:0003677 IEA
    protein binding GO:0005515 IPI
    transcription factor binding GO:0008134 IEA
Biological Process
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IEA
    transcription from RNA polymerase II promoter GO:0006366 IEA
Subcellular Localization
    nucleus GO:0005634 IEA
 Experiment description of studies that identified LCOR in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for LCOR
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which LCOR is involved
No pathways found





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