Gene description for LRP1
Gene name low density lipoprotein receptor-related protein 1
Gene symbol LRP1
Other names/aliases A2MR
APOER
APR
CD91
IGFBP3R
LRP
LRP1A
TGFBR5
Species Homo sapiens
 Database cross references - LRP1
ExoCarta ExoCarta_4035
Vesiclepedia VP_4035
Entrez Gene 4035
HGNC 6692
MIM 107770
UniProt Q07954  
 LRP1 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Chondrocytes 35931686    
Chondrocytes 35931686    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Hepatocellular carcinoma cells 26054723    
Mesenchymal stem cells Unpublished / Not applicable
Mesenchymal stem cells 36408942    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Plasma 19028452    
Platelets 25332113    
Platelets 25332113    
Platelets 25332113    
Prostate cancer cells 25844599    
Thymus 23844026    
 Gene ontology annotations for LRP1
Molecular Function
    amyloid-beta binding GO:0001540 IC
    RNA binding GO:0003723 HDA
    low-density lipoprotein particle receptor activity GO:0005041 TAS
    scavenger receptor activity GO:0005044 TAS
    calcium ion binding GO:0005509 ISS
    protein binding GO:0005515 IPI
    alpha-2 macroglobulin receptor activity GO:0016964 IMP
    alpha-2 macroglobulin receptor activity GO:0016964 TAS
    apolipoprotein receptor activity GO:0030226 TAS
    clathrin heavy chain binding GO:0032050 IPI
    apolipoprotein binding GO:0034185 IBA
    apolipoprotein binding GO:0034185 IDA
    apolipoprotein binding GO:0034185 IPI
    signaling receptor activity GO:0038023 TAS
    cargo receptor activity GO:0038024 IBA
    cargo receptor activity GO:0038024 IMP
    cargo receptor activity GO:0038024 ISS
    cargo receptor activity GO:0038024 NAS
    heparan sulfate proteoglycan binding GO:0043395 TAS
    protein-containing complex binding GO:0044877 IDA
    lipoprotein particle receptor binding GO:0070325 IC
Biological Process
    retinoid metabolic process GO:0001523 TAS
    astrocyte activation involved in immune response GO:0002265 ISS
    lipid metabolic process GO:0006629 TAS
    receptor-mediated endocytosis GO:0006898 IBA
    receptor-mediated endocytosis GO:0006898 IMP
    receptor-mediated endocytosis GO:0006898 ISS
    phagocytosis GO:0006909 IBA
    phagocytosis GO:0006909 IMP
    phagocytosis GO:0006909 NAS
    lysosomal transport GO:0007041 ISS
    enzyme-linked receptor protein signaling pathway GO:0007167 ISS
    negative regulation of gene expression GO:0010629 ISS
    regulation of extracellular matrix disassembly GO:0010715 TAS
    positive regulation of cholesterol efflux GO:0010875 ISS
    negative regulation of smooth muscle cell migration GO:0014912 ISS
    negative regulation of Wnt signaling pathway GO:0030178 ISS
    receptor internalization GO:0031623 TAS
    positive regulation of protein binding GO:0032092 IGI
    positive regulation of lipid transport GO:0032370 ISS
    regulation of cholesterol transport GO:0032374 ISS
    regulation of phospholipase A2 activity GO:0032429 ISS
    regulation of actin cytoskeleton organization GO:0032956 ISS
    aorta morphogenesis GO:0035909 ISS
    lipoprotein transport GO:0042953 NAS
    apoptotic cell clearance GO:0043277 ISS
    transcytosis GO:0045056 TAS
    positive regulation of endocytosis GO:0045807 IGI
    negative regulation of SMAD protein signal transduction GO:0060392 ISS
    amyloid-beta clearance GO:0097242 NAS
    amyloid-beta clearance GO:0097242 TAS
    amyloid-beta clearance by transcytosis GO:0150093 IBA
    amyloid-beta clearance by transcytosis GO:0150093 IGI
    amyloid-beta clearance by transcytosis GO:0150093 ISS
    amyloid-beta clearance by cellular catabolic process GO:0150094 IBA
    amyloid-beta clearance by cellular catabolic process GO:0150094 IMP
    amyloid-beta clearance by cellular catabolic process GO:0150094 ISS
    transport across blood-brain barrier GO:0150104 ISS
    transport across blood-brain barrier GO:0150104 NAS
    positive regulation of amyloid-beta clearance GO:1900223 ISS
    positive regulation of amyloid-beta clearance GO:1900223 TAS
    positive regulation of protein localization to plasma membrane GO:1903078 IGI
    positive regulation of transcytosis GO:1904300 ISS
    cellular response to amyloid-beta GO:1904646 ISS
    negative regulation of metallopeptidase activity GO:1905049 IC
    positive regulation of lysosomal protein catabolic process GO:1905167 IMP
    negative regulation of platelet-derived growth factor receptor-beta signaling pathway GO:2000587 ISS
Subcellular Localization
    nucleus GO:0005634 IEA
    lysosomal membrane GO:0005765 HDA
    early endosome GO:0005769 IDA
    Golgi apparatus GO:0005794 IEA
    microtubule organizing center GO:0005815 IEA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 ISS
    plasma membrane GO:0005886 TAS
    clathrin-coated pit GO:0005905 IEA
    focal adhesion GO:0005925 HDA
    membrane GO:0016020 NAS
    basolateral plasma membrane GO:0016323 IDA
    endocytic vesicle membrane GO:0030666 TAS
    receptor complex GO:0043235 IDA
    plasma membrane protein complex GO:0098797 TAS
 Experiment description of studies that identified LRP1 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 494
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD151|CD63|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Osteoarthritic cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 496
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|SDCBP|TFRC|TSG101
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name Healthy cartilage
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
9
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
10
Experiment ID 235
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
11
Experiment ID 126
MISEV standards
✘ Biophysical techniques
✔
GAPDH
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry [LTQ-FT Ultra]
PubMed ID Unpublished / Not applicable
Organism Homo sapiens
Experiment description Mesenchymal Stem Cell Exosomes: The Future MSC-based Therapy?
Authors "Ruenn Chai Lai, Ronne Wee Yeh Yeo, Soon Sim Tan, Bin Zhang, Yijun Yin, Newman Siu Kwan Sze, Andre Choo, and Sai Kiang Lim"
Journal name Mesenchymal Stem Cell Therapy
Publication year 2011
Sample Mesenchymal stem cells
Sample name huES9.E1
Isolation/purification methods HPLC
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Antobody array
Mass spectrometry
12
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
13
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
14
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
15
Experiment ID 44
MISEV standards
✔
IEM
Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19028452    
Organism Homo sapiens
Experiment description Proteomic profiling of human plasma exosomes identifies PPARgamma as an exosome-associated protein.
Authors "Looze C, Yui D, Leung L, Ingham M, Kaler M, Yao X, Wu WW, Shen RF, Daniels MP, Levine SJ"
Journal name BBRC
Publication year 2009
Sample Plasma
Sample name Plasma
Isolation/purification methods Filtration
Size exclusion
Sucrose density gradient
Flotation density 1.15-1.16 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
16
Experiment ID 231
MISEV standards
✘ Biophysical techniques
✔
Alix|CD63|CD9
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Lipids
Methods used in the study Western blotting
Mass spectrometry
17
Experiment ID 232
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
18
Experiment ID 233
MISEV standards
✘ Biophysical techniques
✘ Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25332113    
Organism Homo sapiens
Experiment description Lipidomic and proteomic characterization of platelet extracellular vesicle subfractions from senescent platelets
Authors "Pienimaeki-Roemer A, Kuhlmann K, Bottcher A, Konovalova T, Black A, Orso E, Liebisch G, Ahrens M, Eisenacher M, Meyer HE, Schmitz G."
Journal name Transfusion
Publication year 2015
Sample Platelets
Sample name PL-Exs - Rep 3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Optiprep density gradient
Flotation density 1.12-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
19
Experiment ID 275
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
20
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for LRP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FOXF1 2294
Affinity Capture-MS Homo sapiens
2 NPC2 10577
Affinity Capture-MS Homo sapiens
3 SHC1 6464
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
4 NOS1AP  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
5 GULP1 51454
Reconstituted Complex Homo sapiens
6 MTPAP 55149
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
7 FAM132B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
8 TUBB8 347688
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 MTG2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 DAB1 1600
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
11 CHFR  
Affinity Capture-Western Homo sapiens
12 SAMD1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
13 TRMT44  
Affinity Capture-MS Homo sapiens
14 GATB  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 APBB1  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
16 APP 351
Affinity Capture-Western Homo sapiens
17 RAB39B 116442
Affinity Capture-MS Homo sapiens
18 SNRNP70 6625
Two-hybrid Homo sapiens
19 B3GNT2 10678
Affinity Capture-MS Homo sapiens
20 DIAPH1 1729
Affinity Capture-MS Homo sapiens
21 PC 5091
Affinity Capture-MS Homo sapiens
22 GFPT1 2673
Affinity Capture-MS Homo sapiens
23 USP3 9960
Affinity Capture-MS Homo sapiens
24 SENP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 HARS2 23438
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 COPS5 10987
Affinity Capture-Western Homo sapiens
27 CALD1 800
Cross-Linking-MS (XL-MS) Homo sapiens
28 GLMP 112770
Affinity Capture-MS Homo sapiens
29 SRC 6714
Biochemical Activity Homo sapiens
30 F9 2158
Reconstituted Complex Homo sapiens
31 TRO  
Affinity Capture-MS Homo sapiens
32 LPL 4023
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
33 MMP14 4323
Affinity Capture-Western Homo sapiens
34 SMOC1 64093
Affinity Capture-MS Homo sapiens
35 ERAL1  
Affinity Capture-MS Homo sapiens
36 INTS6 26512
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 SLC25A25  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 CALR 811
Affinity Capture-Western Homo sapiens
39 LGALS9 3965
Affinity Capture-MS Homo sapiens
40 LIPC  
Reconstituted Complex Homo sapiens
41 HK1 3098
Co-fractionation Homo sapiens
42 MAPK8IP2  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
43 RAB4A 5867
Proximity Label-MS Homo sapiens
44 DDX19B 11269
Affinity Capture-MS Homo sapiens
45 LCOR 84458
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 PTGES2 80142
Affinity Capture-MS Homo sapiens
47 DDX12P  
Affinity Capture-MS Homo sapiens
48 CALCR  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
49 PLAUR 5329
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
50 GCNT1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 PARK2  
Affinity Capture-MS Homo sapiens
52 MTO1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 PCSK5 5125
Affinity Capture-MS Homo sapiens
54 A2M 2
Co-crystal Structure Homo sapiens
55 TUBA1A 7846
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 MAPRE1 22919
Two-hybrid Homo sapiens
57 SCN3A  
Two-hybrid Homo sapiens
58 MAPK8IP1 9479
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
59 TUBB2B 347733
Affinity Capture-MS Homo sapiens
60 TUBA1C 84790
Affinity Capture-MS Homo sapiens
61 ZFP41  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 SYNJ2BP 55333
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
63 PTCD2  
Affinity Capture-MS Homo sapiens
64 ANAPC10  
Two-hybrid Homo sapiens
65 THBS1 7057
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
66 GSG2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 VDAC2 7417
Co-fractionation Homo sapiens
68 F8 2157
Reconstituted Complex Homo sapiens
69 Nup155  
Affinity Capture-MS Mus musculus
70 RTEL1 51750
Affinity Capture-MS Homo sapiens
71 MAP2K7 5609
Affinity Capture-MS Homo sapiens
72 PID1 55022
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
73 FOXF2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
74 HNRNPDL 9987
Two-hybrid Homo sapiens
75 HSPA5 3309
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 PLAT 5327
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
77 CACNA1A  
Two-hybrid Homo sapiens
78 PDIA2 64714
Affinity Capture-Western Homo sapiens
79 LOXL2 4017
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 CANX 821
Affinity Capture-Western Homo sapiens
81 BCKDHB 594
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 APOE 348
Affinity Capture-Western Homo sapiens
83 NPRL3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
84 TNKS 8658
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
85 TCAF1 9747
Affinity Capture-MS Homo sapiens
86 ITGB1BP1 9270
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
87 CUL3 8452
Affinity Capture-MS Homo sapiens
88 TUBB4B 10383
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
89 EGFR 1956
Two-hybrid Homo sapiens
PCA Homo sapiens
Affinity Capture-MS Homo sapiens
90 SERPINE1 5054
Affinity Capture-Western Homo sapiens
91 TNKS2 80351
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 DLG4  
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
93 ANKRD36B  
Affinity Capture-MS Homo sapiens
94 SLC25A23  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 TUBA4A 7277
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
96 HOXA4  
Affinity Capture-MS Homo sapiens
97 FBXO6 26270
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
98 SNX17 9784
Reconstituted Complex Homo sapiens
99 Tyw3  
Affinity Capture-MS Mus musculus
100 CUBN 8029
Affinity Capture-Western Homo sapiens
101 KAT5  
FRET Homo sapiens
102 NXPH4  
Affinity Capture-MS Homo sapiens
103 PDGFB  
Reconstituted Complex Homo sapiens
104 SLC25A30 253512
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
105 GFPT2 9945
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
106 TUBB2A 7280
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
107 ANKS1B 56899
Two-hybrid Homo sapiens
108 C17orf80 55028
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
109 GIPC1 10755
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
110 DAB2 1601
Reconstituted Complex Homo sapiens
111 SLC25A6 293
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
112 SKIL  
Two-hybrid Homo sapiens
113 HMGB1 3146
Cross-Linking-MS (XL-MS) Homo sapiens
114 RIC8B 55188
Two-hybrid Homo sapiens
115 MDK 4192
Affinity Capture-MS Homo sapiens
116 NME4 4833
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
117 FOXB1  
Affinity Capture-MS Homo sapiens
118 SLC26A6 65010
Affinity Capture-MS Homo sapiens
119 TUBB3 10381
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
120 RANBP9 10048
Affinity Capture-Western Homo sapiens
121 TUBB4A 10382
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
122 TRIM37  
Proximity Label-MS Homo sapiens
123 LRPAP1 4043
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
124 WDR76  
Affinity Capture-MS Homo sapiens
125 RPL23 9349
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
126 APBA2 321
Two-hybrid Homo sapiens
127 RAB11A 8766
Proximity Label-MS Homo sapiens
128 RPUSD3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
129 BRD1 23774
Affinity Capture-MS Homo sapiens
130 KCTD18  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
131 SLC25A5 292
Affinity Capture-MS Homo sapiens
132 CCRN4L  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
133 CC2D1A 54862
Two-hybrid Homo sapiens
134 GNB2 2783
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here