Gene description for SLC26A6
Gene name solute carrier family 26 (anion exchanger), member 6
Gene symbol SLC26A6
Other names/aliases -
Species Homo sapiens
 Database cross references - SLC26A6
ExoCarta ExoCarta_65010
Entrez Gene 65010
HGNC 14472
MIM 610068
UniProt Q9BXS9  
 SLC26A6 identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for SLC26A6
Molecular Function
    secondary active sulfate transmembrane transporter activity GO:0008271 IEA
    anion:anion antiporter activity GO:0015301 ISS
    chloride channel activity GO:0005254 IEA
    bicarbonate transmembrane transporter activity GO:0015106 ISS
    formate transmembrane transporter activity GO:0015499 ISS
    sulfate transmembrane transporter activity GO:0015116 IMP
    protein binding GO:0005515 IPI
    formate efflux transmembrane transporter activity GO:0015660 ISS
    PDZ domain binding GO:0030165 ISS
    chloride transmembrane transporter activity GO:0015108 ISS
    efflux transmembrane transporter activity GO:0015562 ISS
    formate uptake transmembrane transporter activity GO:0015659 ISS
    oxalate transmembrane transporter activity GO:0019531 IMP
Biological Process
    transepithelial transport GO:0070633 ISS
    regulation of intracellular pH GO:0051453 IMP
    formate transport GO:0015724 ISS
    cellular response to fructose stimulus GO:0071332 ISS
    chloride transmembrane transport GO:1902476 ISS
    protein kinase C signaling GO:0070528 IDA
    bicarbonate transport GO:0015701 IMP
    angiotensin-activated signaling pathway GO:0038166 IDA
    anion transmembrane transport GO:0098656 ISS
    sulfate transport GO:0008272 ISS
    oxalic acid secretion GO:0046724 ISS
    epithelial fluid transport GO:0042045 ISS
    ion transport GO:0006811 TAS
    positive regulation of dipeptide transmembrane transport GO:2001150 ISS
    chloride transport GO:0006821 IMP
    oxalate transport GO:0019532 ISS
    cellular response to cAMP GO:0071320 ISS
    transmembrane transport GO:0055085 TAS
    intracellular pH elevation GO:0051454 ISS
    sulfate transmembrane transport GO:1902358 IMP
    mannitol transport GO:0015797 ISS
    sperm capacitation GO:0048240 ISS
    intestinal absorption GO:0050892 ISS
    cellular response to interferon-gamma GO:0071346 IDA
    transepithelial chloride transport GO:0030321 ISS
Subcellular Localization
    intracellular GO:0005622 IDA
    apical plasma membrane GO:0016324 IDA
    membrane GO:0016020 ISS
    plasma membrane GO:0005886 TAS
    endoplasmic reticulum GO:0005783 IEA
    integral component of plasma membrane GO:0005887 IEA
    cytoplasmic vesicle membrane GO:0030659 IEA
    integral component of membrane GO:0016021 IDA
    vesicle membrane GO:0012506 ISS
    membrane-bounded vesicle GO:0031988 ISS
    brush border membrane GO:0031526 IDA
    sperm midpiece GO:0097225 ISS
    chloride channel complex GO:0034707 IEA
    basolateral plasma membrane GO:0016323 IDA
 Experiment description of studies that identified SLC26A6 in exosomes
1
Experiment ID 207
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|HSP70
EV Cytosolic markers
✔
FLOT1
EV Membrane markers
✔
VDAC
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 208
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|HSP70
EV Cytosolic markers
✔
FLOT1
EV Membrane markers
✔
VDAC
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 209
ISEV standards
✘ EV Biophysical techniques
✔
TSG101|HSP70
EV Cytosolic markers
✔
FLOT1
EV Membrane markers
✔
VDAC
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ.
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
4
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
5
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SLC26A6
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which SLC26A6 is involved
PathwayEvidenceSource
Multifunctional anion exchangers TAS Reactome





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