Gene description for SLC26A6
Gene name solute carrier family 26 (anion exchanger), member 6
Gene symbol SLC26A6
Other names/aliases -
Species Homo sapiens
 Database cross references - SLC26A6
ExoCarta ExoCarta_65010
Vesiclepedia VP_65010
Entrez Gene 65010
HGNC 14472
MIM 610068
UniProt Q9BXS9  
 SLC26A6 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 23161513    
Colorectal cancer cells 34887515    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for SLC26A6
Molecular Function
    chloride channel activity GO:0005254 IEA
    solute:inorganic anion antiporter activity GO:0005452 IDA
    solute:inorganic anion antiporter activity GO:0005452 IMP
    solute:inorganic anion antiporter activity GO:0005452 ISS
    solute:inorganic anion antiporter activity GO:0005452 TAS
    protein binding GO:0005515 IPI
    secondary active sulfate transmembrane transporter activity GO:0008271 IEA
    bicarbonate transmembrane transporter activity GO:0015106 IBA
    bicarbonate transmembrane transporter activity GO:0015106 IDA
    chloride transmembrane transporter activity GO:0015108 IBA
    chloride transmembrane transporter activity GO:0015108 IDA
    sulfate transmembrane transporter activity GO:0015116 IBA
    sulfate transmembrane transporter activity GO:0015116 IDA
    sulfate:bicarbonate antiporter activity GO:0015383 IDA
    formate transmembrane transporter activity GO:0015499 ISS
    efflux transmembrane transporter activity GO:0015562 ISS
    transferase activity GO:0016740 IEA
    oxalate transmembrane transporter activity GO:0019531 IBA
    PDZ domain binding GO:0030165 ISS
    identical protein binding GO:0042802 IPI
    chloride:bicarbonate antiporter activity GO:0140900 IDA
Biological Process
    monoatomic ion transport GO:0006811 TAS
    chloride transport GO:0006821 IDA
    chloride transport GO:0006821 IMP
    bicarbonate transport GO:0015701 IDA
    bicarbonate transport GO:0015701 IEA
    bicarbonate transport GO:0015701 IMP
    formate transport GO:0015724 ISS
    mannitol transmembrane transport GO:0015797 ISS
    oxalate transport GO:0019532 IMP
    oxalate transport GO:0019532 ISS
    transepithelial chloride transport GO:0030321 IMP
    transepithelial chloride transport GO:0030321 ISS
    angiotensin-activated signaling pathway GO:0038166 IDA
    epithelial fluid transport GO:0042045 ISS
    estrous cycle GO:0044849 IEA
    oxalic acid secretion GO:0046724 ISS
    sperm capacitation GO:0048240 ISS
    intestinal absorption GO:0050892 ISS
    regulation of intracellular pH GO:0051453 IDA
    regulation of intracellular pH GO:0051453 IMP
    intracellular pH elevation GO:0051454 ISS
    establishment of localization in cell GO:0051649 IEA
    protein kinase C signaling GO:0070528 IDA
    transepithelial transport GO:0070633 ISS
    cellular response to cAMP GO:0071320 ISS
    cellular response to fructose stimulus GO:0071332 ISS
    cellular response to type II interferon GO:0071346 IDA
    sulfate transmembrane transport GO:1902358 IBA
    sulfate transmembrane transport GO:1902358 IEA
    sulfate transmembrane transport GO:1902358 IMP
    sulfate transmembrane transport GO:1902358 ISS
    chloride transmembrane transport GO:1902476 IBA
    chloride transmembrane transport GO:1902476 IEA
    positive regulation of dipeptide transmembrane transport GO:2001150 ISS
Subcellular Localization
    endoplasmic reticulum GO:0005783 IEA
    cytosol GO:0005829 IDA
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    vesicle membrane GO:0012506 ISS
    membrane GO:0016020 IDA
    membrane GO:0016020 ISS
    basolateral plasma membrane GO:0016323 IDA
    apical plasma membrane GO:0016324 IDA
    cytoplasmic vesicle membrane GO:0030659 IEA
    brush border membrane GO:0031526 IDA
    vesicle GO:0031982 ISS
    chloride channel complex GO:0034707 IEA
    sperm midpiece GO:0097225 ISS
 Experiment description of studies that identified SLC26A6 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 207
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DKO-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
6
Experiment ID 208
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name Dks-8
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
7
Experiment ID 209
MISEV standards
✘ Biophysical techniques
✔
TSG101|HSP70|FLOT1
Enriched markers
✔
VDAC
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23161513    
Organism Homo sapiens
Experiment description Proteomic analysis of exosomes from mutant KRAS colon cancer cells identifies intercellular transfer of mutant KRAS.
Authors "Demory Beckler M, Higginbotham JN, Franklin JL, Ham AJ, Halvey PJ, Imasuen IE, Whitwell C, Li M, Liebler DC, Coffey RJ."
Journal name Mol Cell Proteomics
Publication year 2012
Sample Colorectal cancer cells
Sample name DLD-1
Isolation/purification methods Differential centrifugation
Filtration
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
8
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
9
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
10
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SLC26A6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MFSD12  
Affinity Capture-MS Homo sapiens
2 LMBRD2 92255
Affinity Capture-MS Homo sapiens
3 ND1  
Affinity Capture-MS Homo sapiens
4 NT5E 4907
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
5 LAT 27040
Two-hybrid Homo sapiens
6 SLC15A1  
Affinity Capture-MS Homo sapiens
7 AQP2 359
Two-hybrid Homo sapiens
8 FAF2 23197
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 TP53 7157
Affinity Capture-MS Homo sapiens
10 PLP1 5354
Two-hybrid Homo sapiens
11 ABCB8 11194
Affinity Capture-MS Homo sapiens
12 C14orf1 11161
Two-hybrid Homo sapiens
13 LAMP3  
Proximity Label-MS Homo sapiens
14 LGALS9C  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 SCPEP1 59342
Affinity Capture-MS Homo sapiens
16 VAC14 55697
Affinity Capture-MS Homo sapiens
17 TNFSF8  
Affinity Capture-MS Homo sapiens
18 PXMP2  
Affinity Capture-MS Homo sapiens
19 ENPP6 133121
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 BET1 10282
Two-hybrid Homo sapiens
21 PDCD1  
Affinity Capture-MS Homo sapiens
22 SLC26A6 65010
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
23 TMEM128  
Two-hybrid Homo sapiens
24 SLC26A2 1836
Affinity Capture-MS Homo sapiens
25 FLOT2 2319
Affinity Capture-MS Homo sapiens
26 ARF6 382
Proximity Label-MS Homo sapiens
27 CD79A  
Affinity Capture-MS Homo sapiens
28 PPP6R2 9701
Affinity Capture-MS Homo sapiens
29 MTX1 4580
Affinity Capture-MS Homo sapiens
30 LPCAT3 10162
Affinity Capture-MS Homo sapiens
31 RAB35 11021
Proximity Label-MS Homo sapiens
32 ARL8B 55207
Affinity Capture-MS Homo sapiens
33 ARHGDIB 397
Affinity Capture-MS Homo sapiens
34 LRP1 4035
Affinity Capture-MS Homo sapiens
35 HACD2 201562
Affinity Capture-MS Homo sapiens
36 C2orf82  
Two-hybrid Homo sapiens
37 SLC7A3  
Affinity Capture-MS Homo sapiens
38 APOL2 23780
Two-hybrid Homo sapiens
39 KRTCAP2 200185
Affinity Capture-MS Homo sapiens
40 ATP2B2 491
Affinity Capture-MS Homo sapiens
41 SLC6A8 6535
Affinity Capture-MS Homo sapiens
42 SLC25A17 10478
Affinity Capture-MS Homo sapiens
43 CD81 975
Two-hybrid Homo sapiens
44 LDLR 3949
Negative Genetic Homo sapiens
45 TNFRSF10C  
Affinity Capture-MS Homo sapiens
46 KRAS 3845
Proximity Label-MS Homo sapiens
47 P2RX2  
Affinity Capture-MS Homo sapiens
48 RHOB 388
Proximity Label-MS Homo sapiens
49 LGALS3 3958
Affinity Capture-MS Homo sapiens
50 ABHD17B 51104
Affinity Capture-MS Homo sapiens
51 IRGC  
Affinity Capture-MS Homo sapiens
52 TMEM201 199953
Two-hybrid Homo sapiens
53 PMEL 6490
Affinity Capture-MS Homo sapiens
54 SLC25A46 91137
Affinity Capture-MS Homo sapiens
55 PKNOX2  
Affinity Capture-MS Homo sapiens
56 TMCO3 55002
Affinity Capture-MS Homo sapiens
57 ORMDL2 29095
Affinity Capture-MS Homo sapiens
58 TSPAN10 83882
Affinity Capture-MS Homo sapiens
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