ExoCarta: Gene summary

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Gene description for C14orf1
Gene name	chromosome 14 open reading frame 1
Gene symbol	C14orf1
Other names/aliases	ERG28 NET51
Species	Homo sapiens
Database cross references - C14orf1
ExoCarta	ExoCarta_11161
Vesiclepedia	VP_11161
Entrez Gene	11161
HGNC	1187
MIM	604576
UniProt	Q9UKR5
C14orf1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Squamous carcinoma cells	20124223

Gene ontology annotations for C14orf1

Molecular Function
	protein binding	GO:0005515	IPI
	protein-macromolecule adaptor activity	GO:0030674	IBA
	identical protein binding	GO:0042802	IPI
Biological Process
	sterol biosynthetic process	GO:0016126	IEA
Subcellular Localization
	endoplasmic reticulum	GO:0005783	IBA
	endoplasmic reticulum membrane	GO:0005789	IEA
	membrane	GO:0016020	NAS
	transport vesicle	GO:0030133	IDA

Experiment description of studies that identified C14orf1 in exosomes

Experiment ID

489

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 6

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

490

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 7

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

491

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 8

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

492

MISEV standards
✔ EM	Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	Enriched markers
✔ Canx	Negative markers
✔ NTA	Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

"Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 9

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

191

MISEV standards
✘	Biophysical techniques
✔ Alix\|CD81\|CD9	Enriched markers
✘	Negative markers
✘	Particle analysis

Identified molecule

protein

Identification method

Mass spectrometry

PubMed ID

20124223

Organism

Homo sapiens

Experiment description

Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.

Authors

"Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK."

Journal name

Mol Cell Proteomics

Publication year

2010

Sample

Squamous carcinoma cells

Sample name

Squamous carcinoma cell (A431)

Isolation/purification methods

Differential centrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Mass spectrometry

Protein-protein interactions for C14orf1

Protein Interactor

ExoCarta ID

Identification method

PubMed

Species

HSD17B11

51170

Two-hybrid

Homo sapiens

PQBP1

Two-hybrid

Homo sapiens

ZNF24

Two-hybrid

Homo sapiens

SNRPG

6637

Two-hybrid

Homo sapiens

NAT9

Two-hybrid

Homo sapiens

TK1

7083

Two-hybrid		Homo sapiens
Two-hybrid		Homo sapiens

GADD45A

Two-hybrid

Homo sapiens

TTR

7276

Two-hybrid

Homo sapiens

ALDH2

217

Two-hybrid

Homo sapiens

SULT1E1

6783

Two-hybrid

Homo sapiens

MS4A3

Two-hybrid

Homo sapiens

LHFPL5

Two-hybrid

Homo sapiens

CCL18

Two-hybrid

Homo sapiens

TMPRSS2

7113

Two-hybrid

Homo sapiens

PHYHIP

9796

Two-hybrid

Homo sapiens

STX1A

6804

Two-hybrid

Homo sapiens

SGPL1

8879

Two-hybrid

Homo sapiens

TMEM222

84065

Two-hybrid

Homo sapiens

NCR3LG1

374383

Two-hybrid

Homo sapiens

FAM174A

345757

Two-hybrid

Homo sapiens

MUC1

4582

Two-hybrid

Homo sapiens

NSF

4905

Two-hybrid

Homo sapiens

SLC10A6

Two-hybrid

Homo sapiens

CRADD

Two-hybrid

Homo sapiens

NR1H2

Two-hybrid

Homo sapiens

NDUFA3

Two-hybrid

Homo sapiens

DYNLL1

8655

Two-hybrid

Homo sapiens

HIATL1

84641

Two-hybrid

Homo sapiens

POLR2C

5432

Two-hybrid

Homo sapiens

KLHL20

Two-hybrid

Homo sapiens

TMEM63C

Affinity Capture-MS

Homo sapiens

COX17

Two-hybrid

Homo sapiens

GPX8

493869

Two-hybrid

Homo sapiens

MPHOSPH6

10200

Two-hybrid

Homo sapiens

CLN8

2055

Two-hybrid

Homo sapiens

FFAR2

Two-hybrid

Homo sapiens

SSMEM1

Two-hybrid

Homo sapiens

MTERF3

Two-hybrid

Homo sapiens

GSK3B

2932

Two-hybrid

Homo sapiens

MAPK8IP2

Two-hybrid

Homo sapiens

FAS

355

Two-hybrid

Homo sapiens

LSM2

57819

Two-hybrid

Homo sapiens

SERPINB9

5272

Two-hybrid

Homo sapiens

PFN1

5216

Two-hybrid

Homo sapiens

ANXA7

310

Two-hybrid

Homo sapiens

SEPHS1

22929

Two-hybrid

Homo sapiens

CLDN7

1366

Two-hybrid

Homo sapiens

CELF3

Two-hybrid

Homo sapiens

REEP4

Two-hybrid

Homo sapiens

PIGY

84992

Two-hybrid

Homo sapiens

STOM

2040

Two-hybrid

Homo sapiens

JAGN1

84522

Two-hybrid

Homo sapiens

CSTF2

1478

Two-hybrid

Homo sapiens

POLR3F

Two-hybrid

Homo sapiens

TM4SF19

Two-hybrid

Homo sapiens

PPP1R8

5511

Two-hybrid

Homo sapiens

S100A8

6279

Two-hybrid

Homo sapiens

PCDHA4

56144

Two-hybrid

Homo sapiens

CREB3

Two-hybrid

Homo sapiens

PDZK1IP1

10158

Two-hybrid

Homo sapiens

KCNJ6

Two-hybrid

Homo sapiens

ENO1

2023

Affinity Capture-RNA

Homo sapiens

TMEM56

Two-hybrid

Homo sapiens

SCN3B

Affinity Capture-MS		Homo sapiens
Two-hybrid		Homo sapiens

GJB5

Two-hybrid

Homo sapiens

RPS6KA6

27330

Two-hybrid

Homo sapiens

MAP2K7

5609

Affinity Capture-MS

Homo sapiens

MRM1

Two-hybrid

Homo sapiens

AQP2

359

Two-hybrid		Homo sapiens
Two-hybrid		Homo sapiens

MRPS12

Two-hybrid

Homo sapiens

C14orf1

11161

Two-hybrid		Homo sapiens
Two-hybrid		Homo sapiens

SNRPB

6628

Two-hybrid

Homo sapiens

NDUFA4L2

56901

Two-hybrid

Homo sapiens

ANXA1

301

Two-hybrid

Homo sapiens

LYPD5

284348

Two-hybrid

Homo sapiens

BCAP31

10134

Affinity Capture-MS

Homo sapiens

SLC34A2

10568

Two-hybrid

Homo sapiens

POLE2

Two-hybrid

Homo sapiens

HTR2C

Two-hybrid

Homo sapiens

HYLS1

Two-hybrid

Homo sapiens

AQP3

Two-hybrid

Homo sapiens

HNRNPUL1

11100

Two-hybrid

Homo sapiens

CREB3L1

Two-hybrid

Homo sapiens

TFG

10342

Two-hybrid

Homo sapiens

CDC42

998

Two-hybrid

Homo sapiens

CDK5RAP2

55755

Two-hybrid

Homo sapiens

GPR152

Two-hybrid

Homo sapiens

FAM209A

200232

Two-hybrid

Homo sapiens

CLDN5

7122

Two-hybrid

Homo sapiens

TMEM106A

Two-hybrid

Homo sapiens

FAM134C

162427

Two-hybrid

Homo sapiens

WRB

7485

Two-hybrid

Homo sapiens

PSCA

8000

Two-hybrid

Homo sapiens

CD53

963

Two-hybrid

Homo sapiens

MOV10

4343

Affinity Capture-RNA

Homo sapiens

PEX2

Two-hybrid

Homo sapiens

MRPL38

Two-hybrid

Homo sapiens

BAIAP2

10458

Two-hybrid

Homo sapiens

RAB27A

5873

Two-hybrid

Homo sapiens

100

HSPE1

3336

Two-hybrid

Homo sapiens

101

PAFAH1B3

5050

Two-hybrid

Homo sapiens

102

HMGB1

3146

Two-hybrid

Homo sapiens

103

FXR1

8087

Two-hybrid

Homo sapiens

104

SLC26A6

65010

Two-hybrid

Homo sapiens

105

HAVCR2

Affinity Capture-MS

Homo sapiens

106

ZFP64

Two-hybrid

Homo sapiens

107

BID

Two-hybrid

Homo sapiens

108

MTNR1B

Two-hybrid

Homo sapiens

109

CCDC106

Two-hybrid

Homo sapiens

110

EBP

Two-hybrid

Homo sapiens

111

SAT1

Two-hybrid

Homo sapiens

112

CREB1

Two-hybrid

Homo sapiens

113

BTBD2

Two-hybrid

Homo sapiens

114

TSC22D1

8848

Two-hybrid

Homo sapiens

115

HNRNPH3

3189

Two-hybrid

Homo sapiens

116

TOMM5

Co-fractionation

Homo sapiens

117

GPR37L1

Two-hybrid

Homo sapiens

118

LDLR

3949

Negative Genetic

Homo sapiens

119

TMEM31

Two-hybrid

Homo sapiens

120

ELOVL4

Two-hybrid

Homo sapiens

121

MGST3

4259

Two-hybrid

Homo sapiens

View the network

Pathways in which C14orf1 is involved
No pathways found

Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here