ExoCarta: Gene summary

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Gene description for C14orf1
Gene name	chromosome 14 open reading frame 1
Gene symbol	C14orf1
Other names/aliases	ERG28 NET51
Species	Homo sapiens
Database cross references - C14orf1
ExoCarta	ExoCarta_11161
Vesiclepedia	VP_11161
Entrez Gene	11161
HGNC	1187
MIM	604576
UniProt	Q9UKR5
C14orf1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Bone marrow mesenchymal stem cells	36408942
Squamous carcinoma cells	20124223

Gene ontology annotations for C14orf1

Molecular Function
	molecular_function	GO:0003674	ND
Biological Process
	sterol biosynthetic process	GO:0016126	IEA
	biological_process	GO:0008150	ND
Subcellular Localization
	integral component of membrane	GO:0016021	NAS
	endoplasmic reticulum membrane	GO:0005789	IEA
	transport vesicle	GO:0030133	IDA

Experiment description of studies that identified C14orf1 in exosomes

Experiment ID

489

MISEV standards
✔ EM	EV Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	EV Enriched markers
✔ Canx	EV Negative markers
✔ NTA	EV Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 6

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

490

MISEV standards
✔ EM	EV Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	EV Enriched markers
✔ Canx	EV Negative markers
✔ NTA	EV Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 7

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

491

MISEV standards
✔ EM	EV Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	EV Enriched markers
✔ Canx	EV Negative markers
✔ NTA	EV Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 8

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

492

MISEV standards
✔ EM	EV Biophysical techniques
✔ Cd9\|Cd81\|Cd63\|Gapdh\|Sdcbp\|Lamp1\|Aqp1\|Rab5a\|Icam1\|Cd82\|Itga2b\|Tsg101\|Lamp2\|Rab35\|Flot1\|Flot2\|Cd151\|Rab5b\|Tfrc\|Uchl1	EV Enriched markers
✔ Canx	EV Negative markers
✔ NTA	EV Particle analysis

Identified molecule

Protein

Identification method

Mass spectrometry

PubMed ID

36408942

Organism

Rattus norvegicus

Experiment description

Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells

Authors

Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.

Journal name

Proteomics

Publication year

2023

Sample

Bone marrow mesenchymal stem cells

Sample name

BMSC - Passage 9

Isolation/purification methods

Differential centrifugation
Filtration
Ultracentrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Western blotting
Mass spectometry

Experiment ID

191

MISEV standards
✘	EV Biophysical techniques
✔ Alix\|CD81\|CD9	EV Enriched markers
✘	EV Negative markers
✘	EV Particle analysis

Identified molecule

protein

Identification method

Mass spectrometry

PubMed ID

20124223

Organism

Homo sapiens

Experiment description

Hypoxic tumor cell modulates its microenvironment to enhance angiogenic and metastatic potential by secretion of proteins and exosomes.

Authors

Park JE, Tan HS, Datta A, Lai RC, Zhang H, Meng W, Lim SK, Sze SK.

Journal name

Mol Cell Proteomics

Publication year

2010

Sample

Squamous carcinoma cells

Sample name

Squamous carcinoma cell (A431)

Isolation/purification methods

Differential centrifugation

Flotation density

Molecules identified in the study

Protein

Methods used in the study

Mass spectrometry

Protein-protein interactions for C14orf1

Protein Interactor

ExoCarta ID

Identification method

PubMed

Species

POLR2C

5432

Two-hybrid

Homo sapiens

HSU79303

Two-hybrid

Homo sapiens

KLHL20

Two-hybrid

Homo sapiens

SAT

Two-hybrid

Homo sapiens

PQBP1

Two-hybrid

Homo sapiens

COX17

Two-hybrid

Homo sapiens

ZNF24

Two-hybrid

Homo sapiens

MPHOSPH6

10200

Two-hybrid

Homo sapiens

SNRPG

6637

Two-hybrid

Homo sapiens

NAT9

Two-hybrid

Homo sapiens

TK1

7083

Two-hybrid

Homo sapiens

MRPS12

Two-hybrid

Homo sapiens

HMGB1

3146

Two-hybrid

Homo sapiens

TNRC4

Two-hybrid

Homo sapiens

FAS

355

Two-hybrid

Homo sapiens

SERPINB9

5272

Two-hybrid

Homo sapiens

HSPE1

3336

Two-hybrid

Homo sapiens

PFN1

5216

Two-hybrid

Homo sapiens

SNRPB

6628

Two-hybrid

Homo sapiens

NDUFA4L2

56901

Two-hybrid

Homo sapiens

CDK5RAP2

55755

Two-hybrid

Homo sapiens

SEPHS1

22929

Two-hybrid

Homo sapiens

SULT1E1

6783

Two-hybrid

Homo sapiens

ZFP64

Two-hybrid

Homo sapiens

POLE2

Two-hybrid

Homo sapiens

PXMP3

Two-hybrid

Homo sapiens

HYLS1

Two-hybrid

Homo sapiens

CREB1

Two-hybrid

Homo sapiens

CSTF2

1478

Two-hybrid

Homo sapiens

TFG

10342

Two-hybrid

Homo sapiens

CDC42

998

Two-hybrid

Homo sapiens

CCL18

Two-hybrid

Homo sapiens

POLR3F

Two-hybrid

Homo sapiens

BTBD2

Two-hybrid

Homo sapiens

FXR1

8087

Two-hybrid

Homo sapiens

PHYHIP

9796

Two-hybrid

Homo sapiens

DYNLL1

8655

Two-hybrid

Homo sapiens

PPP1R8

5511

Two-hybrid

Homo sapiens

PAFAH1B3

5050

Two-hybrid

Homo sapiens

S100A8

6279

Two-hybrid

Homo sapiens

PCDHA4

56144

Two-hybrid

Homo sapiens

NSF

4905

Two-hybrid

Homo sapiens

HNRNPUL1

11100

Two-hybrid

Homo sapiens

CRADD

Two-hybrid

Homo sapiens

MRPL38

Two-hybrid

Homo sapiens

BAIAP2

10458

Two-hybrid

Homo sapiens

ALDH2

217

Two-hybrid

Homo sapiens

RAB27A

5873

Two-hybrid

Homo sapiens

LSM2

Two-hybrid

Homo sapiens

HNRNPH3

3189

Two-hybrid

Homo sapiens

View the network

Pathways in which C14orf1 is involved
No pathways found

Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here