Gene description for RPS6KA6
Gene name	ribosomal protein S6 kinase, 90kDa, polypeptide 6
Gene symbol	RPS6KA6
Other names/aliases	PP90RSK4 RSK4
Species	Homo sapiens
Database cross references - RPS6KA6
ExoCarta	ExoCarta_27330
Vesiclepedia	VP_27330
Entrez Gene	27330
HGNC	10435
MIM	300303
UniProt	Q9UK32
RPS6KA6 identified in exosomes derived from the following tissue/cell type
Squamous carcinoma cells	20124223

Gene ontology annotations for RPS6KA6

Molecular Function     magnesium ion binding GO:0000287 IEA     protein kinase activity GO:0004672 TAS     3-phosphoinositide-dependent protein kinase activity GO:0004676 IEA     DNA-dependent protein kinase activity GO:0004677 IEA     AMP-activated protein kinase activity GO:0004679 IEA     eukaryotic translation initiation factor 2alpha kinase activity GO:0004694 IEA     ribosomal protein S6 kinase activity GO:0004711 IBA     protein binding GO:0005515 IPI     ATP binding GO:0005524 IEA     histone H3S10 kinase activity GO:0035175 IEA     histone H3T11 kinase activity GO:0035402 IEA     histone H3T6 kinase activity GO:0035403 IEA     histone H2AXS139 kinase activity GO:0035979 IEA     histone H3S28 kinase activity GO:0044022 IEA     histone H4S1 kinase activity GO:0044023 IEA     histone H2AS1 kinase activity GO:0044024 IEA     histone H2BS14 kinase activity GO:0044025 IEA     histone H3T3 kinase activity GO:0072354 IEA     histone H2AS121 kinase activity GO:0072371 IEA     Rho-dependent protein serine/threonine kinase activity GO:0072518 IEA     protein serine kinase activity GO:0106310 IEA     histone H2BS36 kinase activity GO:0140823 IEA     histone H3S57 kinase activity GO:0140855 IEA     histone H3T45 kinase activity GO:0140857 IEA     histone H2AT120 kinase activity GO:1990244 IEA Biological Process     chromatin remodeling GO:0006338 IEA     DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 IBA     DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator GO:0006978 IMP     signal transduction GO:0007165 TAS     central nervous system development GO:0007417 TAS     TORC1 signaling GO:0038202 IBA     negative regulation of embryonic development GO:0045992 ISS     negative regulation of ERK1 and ERK2 cascade GO:0070373 ISS     negative regulation of mesoderm development GO:2000381 ISS Subcellular Localization     fibrillar center GO:0001650 IDA     nucleoplasm GO:0005654 IBA     nucleoplasm GO:0005654 IDA     nucleolus GO:0005730 IDA     cytoplasm GO:0005737 IBA     mitochondrion GO:0005739 IDA     cytosol GO:0005829 IEA