Gene description for MICAL1
Gene name microtubule associated monooxygenase, calponin and LIM domain containing 1
Gene symbol MICAL1
Other names/aliases MICAL
Species Homo sapiens
 Database cross references - MICAL1
ExoCarta ExoCarta_64780
Entrez Gene 64780
HGNC 20619
MIM 607129
UniProt Q8TDZ2  
 MICAL1 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for MICAL1
Molecular Function
    SH3 domain binding GO:0017124 IPI
    Rab GTPase binding GO:0017137 IEA
    protein binding GO:0005515 IPI
    actin binding GO:0003779 IDA
    FAD binding GO:0071949 IDA
    zinc ion binding GO:0008270 IEA
    oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen GO:0016709 IDA
Biological Process
    oxidation-reduction process GO:0055114 IDA
    negative regulation of protein phosphorylation GO:0001933 IEA
    signal transduction GO:0007165 NAS
    sulfur oxidation GO:0019417 ISS
    negative regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043154 IEA
    actin filament depolymerization GO:0030042 IDA
    cytoskeleton organization GO:0007010 NAS
Subcellular Localization
    intermediate filament GO:0005882 NAS
    cytoplasm GO:0005737 IDA
 Experiment description of studies that identified MICAL1 in exosomes
Experiment ID 217
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for MICAL1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 VIM 7431
Invitro Homo sapiens
2 RAB1A 5861
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
3 NEDD9 4739
Invivo Homo sapiens
Invitro Homo sapiens
Invivo Homo sapiens
Invitro Homo sapiens
View the network image/svg+xml
 Pathways in which MICAL1 is involved
No pathways found

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