Gene description for GSK3B
Gene name	glycogen synthase kinase 3 beta
Gene symbol	GSK3B
Other names/aliases	-
Species	Homo sapiens
Database cross references - GSK3B
ExoCarta	ExoCarta_2932
Entrez Gene	2932
HGNC	4617
MIM	605004
UniProt	P49841
GSK3B identified in exosomes derived from the following tissue/cell type
Endothelial cells	26027894
Hepatocytes	26054723
Ovarian cancer cells	23333927
Ovarian cancer cells	23333927
Squamous carcinoma cells	20124223
Thymus	23844026

Gene ontology annotations for GSK3B

Molecular Function     integrin binding GO:0005178 IEA     tau protein binding GO:0048156 IEA     NF-kappaB binding GO:0051059 IPI     ionotropic glutamate receptor binding GO:0035255 IEA     p53 binding GO:0002039 IDA     protein binding GO:0005515 IPI     protein kinase binding GO:0019901 IPI     RNA polymerase II transcription factor binding GO:0001085 IPI     protein serine/threonine kinase activity GO:0004674 TAS     tau-protein kinase activity GO:0050321 IDA     kinase activity GO:0016301 TAS     beta-catenin binding GO:0008013 IPI     ATP binding GO:0005524 IEA     protein kinase A catalytic subunit binding GO:0034236 IPI     ubiquitin protein ligase binding GO:0031625 IPI Biological Process     positive regulation of peptidyl-serine phosphorylation GO:0033138 IEA     negative regulation of glycogen (starch) synthase activity GO:2000466 TAS     positive regulation of canonical Wnt signaling pathway GO:0090263 TAS     negative regulation of canonical Wnt signaling pathway GO:0090090 TAS     cell migration GO:0016477 IEA     response to lithium ion GO:0010226 IEA     negative regulation of protein binding GO:0032091 IDA     hypermethylation of CpG island GO:0044027 IEA     fat cell differentiation GO:0045444 IEA     negative regulation of protein complex assembly GO:0031333 IMP     organ morphogenesis GO:0009887 IEA     positive regulation of transcription from RNA polymerase II promoter GO:0045944 IEA     positive regulation of protein catabolic process GO:0045732 IC     axon guidance GO:0007411 TAS     protein phosphorylation GO:0006468 IDA     cellular response to mechanical stimulus GO:0071260 IEA     innate immune response GO:0045087 TAS     epidermal growth factor receptor signaling pathway GO:0007173 TAS     glycogen metabolic process GO:0005977 IDA     positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway GO:1901030 ISS     regulation of microtubule-based process GO:0032886 IMP     canonical Wnt signaling pathway GO:0060070 IDA     negative regulation of apoptotic process GO:0043066 IDA     fibroblast growth factor receptor signaling pathway GO:0008543 TAS     canonical Wnt signaling pathway involved in positive regulation of apoptotic process GO:0044337 IEA     establishment of cell polarity GO:0030010 IEA     circadian rhythm GO:0007623 ISS     epithelial to mesenchymal transition GO:0001837 IMP     protein autophosphorylation GO:0046777 IDA     positive regulation of protein complex assembly GO:0031334 IDA     negative regulation of dendrite morphogenesis GO:0050774 IEA     extrinsic apoptotic signaling pathway in absence of ligand GO:0097192 ISS     re-entry into mitotic cell cycle GO:0000320 IEA     negative regulation of neuron maturation GO:0014043 IEA     positive regulation of axon extension GO:0045773 IEA     regulation of cellular response to heat GO:1900034 TAS     neurotrophin TRK receptor signaling pathway GO:0048011 TAS     peptidyl-serine phosphorylation GO:0018105 IDA     Fc-epsilon receptor signaling pathway GO:0038095 TAS     positive regulation of proteasomal ubiquitin-dependent protein catabolic process GO:0032436 IEA     phosphatidylinositol-mediated signaling GO:0048015 TAS     positive regulation of cell-matrix adhesion GO:0001954 IMP     cellular response to heat GO:0034605 TAS     response to drug GO:0042493 IEA     regulation of gene expression by genetic imprinting GO:0006349 IEA     ER overload response GO:0006983 IDA     negative regulation of glycogen biosynthetic process GO:0045719 TAS     positive regulation of protein binding GO:0032092 ISS     protein export from nucleus GO:0006611 IEA     positive regulation of stem cell differentiation GO:2000738 IEA     myoblast fusion GO:0007520 IEA     hippocampus development GO:0021766 IMP     superior temporal gyrus development GO:0071109 IMP     negative regulation of type B pancreatic cell development GO:2000077 TAS     negative regulation of NFAT protein import into nucleus GO:0051534 IMP     intracellular signal transduction GO:0035556 IDA     negative regulation of cardiac muscle hypertrophy GO:0010614 IEA     positive regulation of GTPase activity GO:0043547 IMP     positive regulation of protein export from nucleus GO:0046827 IDA     negative regulation of MAP kinase activity GO:0043407 IEA     protein localization to microtubule GO:0035372 IEA     cellular response to interleukin-3 GO:0036016 ISS     positive regulation of peptidyl-threonine phosphorylation GO:0010800 IEA     regulation of neuronal synaptic plasticity GO:0048168 IEA Subcellular Localization     nucleoplasm GO:0005654 IDA     perinuclear region of cytoplasm GO:0048471 IEA     plasma membrane GO:0005886 IDA     beta-catenin destruction complex GO:0030877 TAS     cytoplasm GO:0005737 IDA     growth cone GO:0030426 IEA     ribonucleoprotein complex GO:0030529 IEA     neuronal cell body GO:0043025 IEA     nucleus GO:0005634 IDA     cytosol GO:0005829 TAS     membrane raft GO:0045121 IEA     dendritic shaft GO:0043198 IEA     centrosome GO:0005813 IDA     dendritic spine GO:0043197 IEA