Gene description for NFE2L3
Gene name nuclear factor, erythroid 2-like 3
Gene symbol NFE2L3
Other names/aliases NRF3
Species Homo sapiens
 Database cross references - NFE2L3
ExoCarta ExoCarta_9603
Entrez Gene 9603
HGNC 7783
MIM 604135
UniProt Q9Y4A8  
 NFE2L3 identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for NFE2L3
Molecular Function
    transcription coactivator activity GO:0003713 TAS
    RNA polymerase II core promoter proximal region sequence-specific DNA binding GO:0000978 IEA
    RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription GO:0001078 IEA
    sequence-specific DNA binding transcription factor activity GO:0003700 TAS
Biological Process
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IEA
    transcription from RNA polymerase II promoter GO:0006366 TAS
Subcellular Localization
    nucleus GO:0005634 IEA
 Experiment description of studies that identified NFE2L3 in exosomes
1
Experiment ID 226
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD9|FLOT1
EV Membrane markers
LMNA|H2AFX|ATP5A1|TOMM20
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting
Authors Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for NFE2L3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 MAFK 7975
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which NFE2L3 is involved
No pathways found





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