Gene description for PSCA
Gene name prostate stem cell antigen
Gene symbol PSCA
Other names/aliases PRO232
Species Homo sapiens
 Database cross references - PSCA
ExoCarta ExoCarta_8000
Vesiclepedia VP_8000
Entrez Gene 8000
HGNC 9500
MIM 602470
 PSCA identified in sEVs derived from the following tissue/cell type
Urine 15326289    
Urine 19056867    
 Gene ontology annotations for PSCA
Molecular Function
    acetylcholine receptor regulator activity GO:0030548 IBA
    acetylcholine receptor binding GO:0033130 IBA
    acetylcholine receptor binding GO:0033130 IDA
Biological Process
    negative regulation of ERK1 and ERK2 cascade GO:0070373 IDA
    acetylcholine receptor signaling pathway GO:0095500 IBA
    regulation of neurotransmitter receptor activity GO:0099601 IBA
    regulation of neurotransmitter receptor activity GO:0099601 IDA
Subcellular Localization
    extracellular region GO:0005576 TAS
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    synapse GO:0045202 IEA
    extracellular exosome GO:0070062 HDA
    side of membrane GO:0098552 IEA
 Experiment description of studies that identified PSCA in sEVs
1
Experiment ID 13
MISEV standards
✔
IEM
Biophysical techniques
✔
Alix|RAB4|RAB5B|RAB11|TSG101|CD9|AQP2|AQP1
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 15326289    
Organism Homo sapiens
Experiment description Identification and proteomic profiling of exosomes in human urine.
Authors "Pisitkun T, Shen RF, Knepper MA"
Journal name PNAS
Publication year 2004
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA XP]
Western blotting
2
Experiment ID 63
MISEV standards
✘ Biophysical techniques
✔
AQP2
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for PSCA
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BRINP3  
Affinity Capture-MS Homo sapiens
2 SLC30A8  
Two-hybrid Homo sapiens
3 AGPAT5 55326
Two-hybrid Homo sapiens
4 SLC35A1 10559
Two-hybrid Homo sapiens
5 CACNA2D1 781
Affinity Capture-MS Homo sapiens
6 CACNA2D2 9254
Affinity Capture-MS Homo sapiens
7 IDUA 3425
Affinity Capture-MS Homo sapiens
8 CD53 963
Two-hybrid Homo sapiens
9 TUSC5  
Two-hybrid Homo sapiens
10 DNAJA4 55466
Affinity Capture-MS Homo sapiens
11 TMEM147 10430
Two-hybrid Homo sapiens
12 CYB561D2 11068
Two-hybrid Homo sapiens
13 AIG1  
Two-hybrid Homo sapiens
14 ITGA4 3676
Affinity Capture-MS Homo sapiens
15 TMEM67 91147
Affinity Capture-MS Homo sapiens
16 ADAMTS2 9509
Affinity Capture-MS Homo sapiens
17 SGCB 6443
Affinity Capture-MS Homo sapiens
18 SLC12A2 6558
Affinity Capture-MS Homo sapiens
19 TGFBR1 7046
Affinity Capture-MS Homo sapiens
20 ITGA7 3679
Affinity Capture-MS Homo sapiens
21 B3GNT2 10678
Affinity Capture-MS Homo sapiens
22 STX8 9482
Two-hybrid Homo sapiens
23 ADGRG1 9289
Affinity Capture-MS Homo sapiens
24 ADAM9 8754
Affinity Capture-MS Homo sapiens
25 VKORC1 79001
Affinity Capture-MS Homo sapiens
26 CD109 135228
Affinity Capture-MS Homo sapiens
27 GLT8D2 83468
Affinity Capture-MS Homo sapiens
28 GPAA1 8733
Affinity Capture-MS Homo sapiens
29 SLC44A5  
Affinity Capture-MS Homo sapiens
30 TSPO2  
Two-hybrid Homo sapiens
31 SYS1  
Two-hybrid Homo sapiens
32 TMEM97 27346
Two-hybrid Homo sapiens
33 TMEM140  
Two-hybrid Homo sapiens
34 DGCR2 9993
Affinity Capture-MS Homo sapiens
35 EOGT 285203
Affinity Capture-MS Homo sapiens
36 UGT3A2  
Affinity Capture-MS Homo sapiens
37 B4GALNT1  
Affinity Capture-MS Homo sapiens
38 MOSPD3  
Two-hybrid Homo sapiens
39 TMEM2 23670
Affinity Capture-MS Homo sapiens
40 SLC16A4  
Two-hybrid Homo sapiens
41 MICA 100507436
Affinity Capture-MS Homo sapiens
42 INSIG2  
Two-hybrid Homo sapiens
43 PLAUR 5329
Affinity Capture-MS Homo sapiens
44 TMEM54  
Two-hybrid Homo sapiens
45 NOMO1 23420
Affinity Capture-MS Homo sapiens
46 GCNT1  
Affinity Capture-MS Homo sapiens
47 ITGA6 3655
Affinity Capture-MS Homo sapiens
48 CLSTN1 22883
Affinity Capture-MS Homo sapiens
49 JAGN1 84522
Two-hybrid Homo sapiens
50 TMTC3 160418
Affinity Capture-MS Homo sapiens
51 SEPN1 57190
Affinity Capture-MS Homo sapiens
52 ATRAID 51374
Affinity Capture-MS Homo sapiens
53 HYAL2 8692
Affinity Capture-MS Homo sapiens
54 APOL2 23780
Two-hybrid Homo sapiens
55 MANEAL 149175
Affinity Capture-MS Homo sapiens
56 C16orf58 64755
Two-hybrid Homo sapiens
57 GLB1L 79411
Affinity Capture-MS Homo sapiens
58 APOA2 336
Two-hybrid Homo sapiens
59 TMEM243  
Two-hybrid Homo sapiens
60 TRPM7 54822
Affinity Capture-MS Homo sapiens
61 BCHE 590
Affinity Capture-MS Homo sapiens
62 WNT5A 7474
Affinity Capture-MS Homo sapiens
63 BMP7 655
Affinity Capture-MS Homo sapiens
64 LRRC8E 80131
Affinity Capture-MS Homo sapiens
65 SEMA4F  
Affinity Capture-MS Homo sapiens
66 ITGA8 8516
Affinity Capture-MS Homo sapiens
67 ATP4A 495
Affinity Capture-MS Homo sapiens
68 TGFBR3 7049
Affinity Capture-MS Homo sapiens
69 PLXNA2 5362
Affinity Capture-MS Homo sapiens
70 MAN2A2 4122
Affinity Capture-MS Homo sapiens
71 CERCAM 51148
Affinity Capture-MS Homo sapiens
72 ST6GAL2  
Two-hybrid Homo sapiens
73 SLC7A1 6541
Two-hybrid Homo sapiens
74 CDIPT 10423
Two-hybrid Homo sapiens
75 ULBP3 79465
Affinity Capture-MS Homo sapiens
76 TMEM262  
Two-hybrid Homo sapiens
77 LAT 27040
Two-hybrid Homo sapiens
78 BCL2L2 599
Two-hybrid Homo sapiens
79 SUSD1 64420
Affinity Capture-MS Homo sapiens
80 HLA-B 3106
Affinity Capture-MS Homo sapiens
81 PIGT 51604
Affinity Capture-MS Homo sapiens
82 C14orf1 11161
Two-hybrid Homo sapiens
83 YIPF6 286451
Two-hybrid Homo sapiens
84 AGPAT1 10554
Affinity Capture-MS Homo sapiens
85 SLC44A1 23446
Affinity Capture-MS Homo sapiens
86 UNC93A  
Two-hybrid Homo sapiens
87 LOXL2 4017
Affinity Capture-MS Homo sapiens
88 EGFR 1956
Affinity Capture-MS Homo sapiens
89 TMEM42  
Two-hybrid Homo sapiens
90 TXNDC15  
Affinity Capture-MS Homo sapiens
91 GYLTL1B 120071
Affinity Capture-MS Homo sapiens
92 TMEM86B  
Two-hybrid Homo sapiens
93 GALNT18  
Affinity Capture-MS Homo sapiens
94 CDHR1  
Affinity Capture-MS Homo sapiens
95 SULF1 23213
Affinity Capture-MS Homo sapiens
96 CMTM5  
Two-hybrid Homo sapiens
97 PPAPDC1A  
Two-hybrid Homo sapiens
98 SLC12A7 10723
Affinity Capture-MS Homo sapiens
99 PLP2 5355
Two-hybrid Homo sapiens
100 FAM69B  
Affinity Capture-MS Homo sapiens
101 PCSK9 255738
Affinity Capture-MS Homo sapiens
102 POGLUT1 56983
Affinity Capture-MS Homo sapiens
103 ST3GAL6 10402
Affinity Capture-MS Homo sapiens
104 METTL15  
Affinity Capture-MS Homo sapiens
105 ATP7A 538
Affinity Capture-MS Homo sapiens
106 PIGS 94005
Affinity Capture-MS Homo sapiens
107 CACNA2D3  
Affinity Capture-MS Homo sapiens
108 TMEM239  
Two-hybrid Homo sapiens
109 FZD6 8323
Affinity Capture-MS Homo sapiens
110 SMIM3  
Two-hybrid Homo sapiens
111 NAAA  
Affinity Capture-MS Homo sapiens
112 GALNS 2588
Affinity Capture-MS Homo sapiens
113 TMEM218  
Two-hybrid Homo sapiens
114 TCTN1  
Affinity Capture-MS Homo sapiens
115 PIGO  
Affinity Capture-MS Homo sapiens
116 NXPH4  
Affinity Capture-MS Homo sapiens
117 ANKRD46 157567
Affinity Capture-MS Homo sapiens
118 PLXNA1 5361
Affinity Capture-MS Homo sapiens
119 VAMP4 8674
Two-hybrid Homo sapiens
120 FAM132B  
Affinity Capture-MS Homo sapiens
121 CDC6  
Affinity Capture-MS Homo sapiens
122 PIGK 10026
Affinity Capture-MS Homo sapiens
123 CHID1 66005
Affinity Capture-MS Homo sapiens
124 LARGE 9215
Affinity Capture-MS Homo sapiens
125 COL6A2 1292
Affinity Capture-MS Homo sapiens
126 GUF1  
Affinity Capture-MS Homo sapiens
127 ITGAV 3685
Affinity Capture-MS Homo sapiens
128 ST3GAL4 6484
Affinity Capture-MS Homo sapiens
129 BRICD5  
Two-hybrid Homo sapiens
130 EXT2 2132
Affinity Capture-MS Homo sapiens
131 ARSG 22901
Affinity Capture-MS Homo sapiens
132 FAM69A 388650
Affinity Capture-MS Homo sapiens
133 SPPL2B 56928
Affinity Capture-MS Homo sapiens
134 GPC3 2719
Affinity Capture-MS Homo sapiens
135 LAMB3 3914
Affinity Capture-MS Homo sapiens
136 LRP11  
Affinity Capture-MS Homo sapiens
137 NFE2L3 9603
Affinity Capture-MS Homo sapiens
138 GLRB  
Affinity Capture-MS Homo sapiens
139 ARSK  
Affinity Capture-MS Homo sapiens
140 MFGE8 4240
Affinity Capture-MS Homo sapiens
141 HLA-C 3107
Affinity Capture-MS Homo sapiens
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