Gene description for IDUA
Gene name iduronidase, alpha-L-
Gene symbol IDUA
Other names/aliases IDA
MPS1
Species Homo sapiens
 Database cross references - IDUA
ExoCarta ExoCarta_3425
Vesiclepedia VP_3425
Entrez Gene 3425
HGNC 5391
MIM 252800
UniProt P35475  
 IDUA identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for IDUA
Molecular Function
    L-iduronidase activity GO:0003940 IBA
    L-iduronidase activity GO:0003940 IDA
    L-iduronidase activity GO:0003940 TAS
    signaling receptor binding GO:0005102 IEA
Biological Process
    disaccharide metabolic process GO:0005984 TAS
    glycosaminoglycan catabolic process GO:0006027 TAS
    heparan sulfate proteoglycan catabolic process GO:0030200 TAS
    dermatan sulfate catabolic process GO:0030209 IDA
    heparin catabolic process GO:0030211 IMP
Subcellular Localization
    lysosomal lumen GO:0043202 TAS
    extracellular exosome GO:0070062 HDA
 Experiment description of studies that identified IDUA in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for IDUA
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LY86  
Affinity Capture-MS Homo sapiens
2 UBE2H 7328
Affinity Capture-MS Homo sapiens
3 C7orf34  
Affinity Capture-MS Homo sapiens
4 FGFBP1 9982
Affinity Capture-MS Homo sapiens
5 GPIHBP1  
Affinity Capture-MS Homo sapiens
6 FMOD 2331
Affinity Capture-MS Homo sapiens
7 BTNL2  
Affinity Capture-MS Homo sapiens
8 LILRA5  
Affinity Capture-MS Homo sapiens
9 NAAA  
Affinity Capture-MS Homo sapiens
10 C1QTNF9B  
Affinity Capture-MS Homo sapiens
11 LCN6  
Affinity Capture-MS Homo sapiens
12 NPTX1  
Affinity Capture-MS Homo sapiens
13 IGLL5 100423062
Affinity Capture-MS Homo sapiens
14 TMEM25  
Affinity Capture-MS Homo sapiens
15 GGH 8836
Affinity Capture-MS Homo sapiens
16 CFC1  
Affinity Capture-MS Homo sapiens
17 PDGFRA 5156
Affinity Capture-MS Homo sapiens
18 MFAP4 4239
Affinity Capture-MS Homo sapiens
19 CRP  
Affinity Capture-MS Homo sapiens
20 CBLN4  
Affinity Capture-MS Homo sapiens
21 LY9 4063
Affinity Capture-MS Homo sapiens
22 FBXO6 26270
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 SLURP1  
Affinity Capture-MS Homo sapiens
24 NCR3  
Affinity Capture-MS Homo sapiens
25 IL5RA  
Affinity Capture-MS Homo sapiens
26 LYZL6  
Affinity Capture-MS Homo sapiens
27 SFTPC  
Affinity Capture-MS Homo sapiens
28 KLK1 3816
Affinity Capture-MS Homo sapiens
29 TAZ  
Affinity Capture-MS Homo sapiens
30 CA6 765
Affinity Capture-MS Homo sapiens
31 SIRPD  
Affinity Capture-MS Homo sapiens
32 IDS  
Affinity Capture-MS Homo sapiens
33 CGREF1 10669
Affinity Capture-MS Homo sapiens
34 FBXO2 26232
Affinity Capture-MS Homo sapiens
35 KIF23 9493
Affinity Capture-MS Homo sapiens
36 SCGB2A2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 C1orf54  
Affinity Capture-MS Homo sapiens
38 PSCA 8000
Affinity Capture-MS Homo sapiens
39 ALPP 250
Affinity Capture-MS Homo sapiens
40 DNAJB9 4189
Affinity Capture-MS Homo sapiens
41 NAGA 4668
Affinity Capture-MS Homo sapiens
42 CA10  
Affinity Capture-MS Homo sapiens
43 CST11  
Affinity Capture-MS Homo sapiens
44 LEP  
Affinity Capture-MS Homo sapiens
45 DNASE1L1 1774
Affinity Capture-MS Homo sapiens
46 ISLR 3671
Affinity Capture-MS Homo sapiens
47 OBSL1 23363
Affinity Capture-MS Homo sapiens
48 DDX58 23586
Affinity Capture-RNA Homo sapiens
49 PTCH1  
Affinity Capture-MS Homo sapiens
50 ELSPBP1  
Affinity Capture-MS Homo sapiens
51 GIP  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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