Gene description for FMOD
Gene name fibromodulin
Gene symbol FMOD
Other names/aliases FM
Species Homo sapiens
 Database cross references - FMOD
ExoCarta ExoCarta_2331
Entrez Gene 2331
HGNC 3774
MIM 600245
UniProt Q06828  
 FMOD identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for FMOD
Biological Process
    keratan sulfate biosynthetic process GO:0018146 TAS
    extracellular matrix organization GO:0030198 TAS
    carbohydrate metabolic process GO:0005975 TAS
    small molecule metabolic process GO:0044281 TAS
    transforming growth factor beta receptor complex assembly GO:0007181 TAS
    keratan sulfate catabolic process GO:0042340 TAS
    keratan sulfate metabolic process GO:0042339 TAS
    glycosaminoglycan metabolic process GO:0030203 TAS
Subcellular Localization
    Golgi lumen GO:0005796 TAS
    lysosomal lumen GO:0043202 TAS
    extracellular matrix GO:0031012 IDA
    extracellular region GO:0005576 TAS
    proteinaceous extracellular matrix GO:0005578 IEA
    extracellular space GO:0005615 IDA
 Experiment description of studies that identified FMOD in exosomes
Experiment ID 275
ISEV standards
EV Biophysical techniques
EV Cytosolic markers
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
 Protein-protein interactions for FMOD
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TGFB1 7040
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
View the network image/svg+xml

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