Gene description for METRNL
Gene name meteorin, glial cell differentiation regulator-like
Gene symbol METRNL
Other names/aliases -
Species Homo sapiens
 Database cross references - METRNL
ExoCarta ExoCarta_284207
Entrez Gene 284207
HGNC 27584
MIM 616241
UniProt Q641Q3  
 METRNL identified in exosomes derived from the following tissue/cell type
Colorectal cancer cells 19837982    
Saliva 19199708    
 Gene ontology annotations for METRNL
Molecular Function
    hormone activity GO:0005179 ISS
    molecular_function GO:0003674 ND
Biological Process
    positive regulation of energy homeostasis GO:2000507 ISS
    positive regulation of brown fat cell differentiation GO:0090336 ISS
    negative regulation of inflammatory response GO:0050728 ISS
    response to cold GO:0009409 ISS
    fat cell differentiation GO:0045444 ISS
    response to muscle activity GO:0014850 ISS
    brown fat cell differentiation GO:0050873 ISS
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    extracellular space GO:0005615 ISS
 Experiment description of studies that identified METRNL in exosomes
1
Experiment ID 21
ISEV standards
EM|IEM
EV Biophysical techniques
Alix|TSG101|HSP70
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method
Mass spectrometry   
PubMed ID 19837982    
Organism Homo sapiens
Experiment description Proteomic and bioinformatic analysis of immunoaffinity-purified exosomes derived from the human colon tumor cell line LIM1215.
Authors Suresh Mathivanan, Justin W.E. Lim, Bow J. Tauro, Hong Ji, Robert L. Moritz and Richard J. Simpson
Journal name MCP
Publication year 2009
Sample Colorectal cancer cells
Sample name LIM1215
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.10-1.12 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [Orbitrap]
Western blotting
2
Experiment ID 66
ISEV standards
IEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
CD63|CD81
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19199708    
Organism Homo sapiens
Experiment description Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT).
Authors Gonzalez-Begne M, Lu B, Han X, Hagen FK, Hand AR, Melvin JE, Yates JR
Journal name JPR
Publication year 2009
Sample Saliva
Sample name Saliva
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for METRNL
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which METRNL is involved
No pathways found





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