Gene description for EPHA7
Gene name EPH receptor A7
Gene symbol EPHA7
Other names/aliases EHK-3
EHK3
EK11
HEK11
Species Homo sapiens
 Database cross references - EPHA7
ExoCarta ExoCarta_2045
Vesiclepedia VP_2045
Entrez Gene 2045
HGNC 3390
MIM 602190
UniProt Q15375  
 EPHA7 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for EPHA7
Molecular Function
    protein tyrosine kinase activity GO:0004713 ISS
    GPI-linked ephrin receptor activity GO:0005004 ISS
    transmembrane-ephrin receptor activity GO:0005005 IBA
    epidermal growth factor receptor activity GO:0005006 IEA
    fibroblast growth factor receptor activity GO:0005007 IEA
    hepatocyte growth factor receptor activity GO:0005008 IEA
    insulin receptor activity GO:0005009 IEA
    insulin-like growth factor receptor activity GO:0005010 IEA
    macrophage colony-stimulating factor receptor activity GO:0005011 IEA
    platelet-derived growth factor alpha-receptor activity GO:0005018 IEA
    platelet-derived growth factor beta-receptor activity GO:0005019 IEA
    stem cell factor receptor activity GO:0005020 IEA
    vascular endothelial growth factor receptor activity GO:0005021 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    axon guidance receptor activity GO:0008046 ISS
    boss receptor activity GO:0008288 IEA
    growth factor binding GO:0019838 IEA
    histone H3Y41 kinase activity GO:0035401 IEA
    placental growth factor receptor activity GO:0036332 IEA
    protein tyrosine kinase collagen receptor activity GO:0038062 IEA
    chemorepellent activity GO:0045499 ISS
    brain-derived neurotrophic factor receptor activity GO:0060175 IEA
    histone H2AXY142 kinase activity GO:0140801 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
    epidermal growth factor receptor signaling pathway GO:0007173 IEA
    axon guidance GO:0007411 IBA
    brain development GO:0007420 ISS
    insulin receptor signaling pathway GO:0008286 IEA
    fibroblast growth factor receptor signaling pathway GO:0008543 IEA
    phosphorylation GO:0016310 ISS
    regulation of cell-cell adhesion GO:0022407 ISS
    retinal ganglion cell axon guidance GO:0031290 IEA
    brain-derived neurotrophic factor receptor signaling pathway GO:0031547 IEA
    regulation of protein autophosphorylation GO:0031952 ISS
    platelet-derived growth factor receptor-alpha signaling pathway GO:0035790 IEA
    platelet-derived growth factor receptor-beta signaling pathway GO:0035791 IEA
    vascular endothelial growth factor receptor-1 signaling pathway GO:0036323 IEA
    collagen-activated tyrosine kinase receptor signaling pathway GO:0038063 IEA
    vascular endothelial growth factor signaling pathway GO:0038084 IEA
    Kit signaling pathway GO:0038109 IEA
    macrophage colony-stimulating factor signaling pathway GO:0038145 IEA
    positive regulation of neuron apoptotic process GO:0043525 ISS
    insulin-like growth factor receptor signaling pathway GO:0048009 IEA
    hepatocyte growth factor receptor signaling pathway GO:0048012 IEA
    ephrin receptor signaling pathway GO:0048013 IBA
    ephrin receptor signaling pathway GO:0048013 IDA
    negative regulation of collateral sprouting GO:0048671 IEA
    branching morphogenesis of a nerve GO:0048755 ISS
    regulation of peptidyl-tyrosine phosphorylation GO:0050730 IDA
    modulation of chemical synaptic transmission GO:0050804 IEA
    negative chemotaxis GO:0050919 ISS
    neuron apoptotic process GO:0051402 IEA
    negative regulation of synapse assembly GO:0051964 IEA
    regulation of ERK1 and ERK2 cascade GO:0070372 IDA
    nephric duct morphogenesis GO:0072178 IEA
    regulation of postsynapse organization GO:0099175 IEA
    regulation of cysteine-type endopeptidase activity GO:2000116 ISS
Subcellular Localization
    plasma membrane GO:0005886 IBA
    plasma membrane GO:0005886 IDA
    plasma membrane GO:0005886 TAS
    dendrite GO:0030425 IBA
    glutamatergic synapse GO:0098978 IEA
 Experiment description of studies that identified EPHA7 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for EPHA7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RYK 6259
Affinity Capture-MS Homo sapiens
2 CSTL1  
Affinity Capture-MS Homo sapiens
3 RAET1E  
Affinity Capture-MS Homo sapiens
4 GJD3  
Proximity Label-MS Homo sapiens
5 ZNF267  
Two-hybrid Homo sapiens
6 NPC2 10577
Affinity Capture-MS Homo sapiens
7 PIK3IP1 113791
Affinity Capture-MS Homo sapiens
8 COL6A1 1291
Affinity Capture-MS Homo sapiens
9 MBLAC2 153364
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 MARCKS 4082
Proximity Label-MS Homo sapiens
11 PLOD1 5351
Affinity Capture-MS Homo sapiens
12 TUBB8 347688
Affinity Capture-MS Homo sapiens
13 LRRIQ1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 MTMR14 64419
Two-hybrid Homo sapiens
15 GPR110  
Affinity Capture-MS Homo sapiens
16 SOX2  
Affinity Capture-MS Homo sapiens
17 EPHA8  
Affinity Capture-MS Homo sapiens
18 EFNA3  
Affinity Capture-Western Homo sapiens
19 PLOD3 8985
Affinity Capture-MS Homo sapiens
20 B3GNT2 10678
Affinity Capture-MS Homo sapiens
21 MLLT4 4301
Two-hybrid Homo sapiens
Proximity Label-MS Homo sapiens
22 PC 5091
Affinity Capture-MS Homo sapiens
23 TGFB1 7040
Affinity Capture-MS Homo sapiens
24 IARS2 55699
Affinity Capture-MS Homo sapiens
25 ADGRG1 9289
Affinity Capture-MS Homo sapiens
26 TMEM231 79583
Affinity Capture-MS Homo sapiens
27 BORA  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 PVR 5817
Affinity Capture-MS Homo sapiens
29 FGFR4 2264
Affinity Capture-MS Homo sapiens
30 OAF 220323
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 SMOC1 64093
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 PCSK6 5046
Affinity Capture-MS Homo sapiens
33 NID2 22795
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 TUBA1A 7846
Affinity Capture-MS Homo sapiens
35 RAB35 11021
Proximity Label-MS Homo sapiens
36 P3H4 10609
Affinity Capture-MS Homo sapiens
37 LAMTOR1 55004
Proximity Label-MS Homo sapiens
38 NXPH4  
Affinity Capture-MS Homo sapiens
39 MICA 100507436
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 AGAP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 EFNA2  
Affinity Capture-Western Homo sapiens
42 MANSC1 54682
Affinity Capture-MS Homo sapiens
43 EFNA5  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 TMX1 81542
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 AVPR1B  
Affinity Capture-MS Homo sapiens
46 LYN 4067
Proximity Label-MS Homo sapiens
47 SLC9A8 23315
Affinity Capture-MS Homo sapiens
48 PRPS2 5634
Co-fractionation Homo sapiens
49 CHPF2 54480
Affinity Capture-MS Homo sapiens
50 EPHA10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 MKRN2 23609
Affinity Capture-RNA Homo sapiens
52 DIRAS3  
Proximity Label-MS Homo sapiens
53 WNT5A 7474
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 RAB2A 5862
Proximity Label-MS Homo sapiens
55 PCSK9 255738
Affinity Capture-MS Homo sapiens
56 IL17RC 84818
Affinity Capture-MS Homo sapiens
57 ART5  
Affinity Capture-MS Homo sapiens
58 PLXNA3 55558
Affinity Capture-MS Homo sapiens
59 TRMT2A 27037
Affinity Capture-MS Homo sapiens
60 MRAP2  
Affinity Capture-MS Homo sapiens
61 ATRN 8455
Affinity Capture-MS Homo sapiens
62 UBR2 23304
Affinity Capture-MS Homo sapiens
63 ENDOG  
Affinity Capture-MS Homo sapiens
64 BCAM 4059
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 PICK1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 HSPA5 3309
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 TUBB 203068
Affinity Capture-MS Homo sapiens
68 TMEM30A 55754
Affinity Capture-MS Homo sapiens
69 TMPRSS11B 132724
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 LAMP1 3916
Proximity Label-MS Homo sapiens
71 METRNL 284207
Affinity Capture-MS Homo sapiens
72 LOXL2 4017
Affinity Capture-MS Homo sapiens
73 DUSP26 78986
Two-hybrid Homo sapiens
74 LTBP3 4054
Affinity Capture-MS Homo sapiens
75 PLOD2 5352
Affinity Capture-MS Homo sapiens
76 ARF6 382
Proximity Label-MS Homo sapiens
77 NPTX1  
Affinity Capture-MS Homo sapiens
78 TUBA4A 7277
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 KCNE3  
Affinity Capture-MS Homo sapiens
80 VWDE  
Affinity Capture-MS Homo sapiens
81 FUT11 170384
Affinity Capture-MS Homo sapiens
82 IL7R  
Affinity Capture-MS Homo sapiens
83 CHRNA5  
Affinity Capture-MS Homo sapiens
84 TMEM132A 54972
Affinity Capture-MS Homo sapiens
85 CRLF1 9244
Affinity Capture-MS Homo sapiens
86 CHRD  
Affinity Capture-MS Homo sapiens
87 GXYLT1 283464
Affinity Capture-MS Homo sapiens
88 DNAJC3 5611
Affinity Capture-MS Homo sapiens
89 P3H3 10536
Affinity Capture-MS Homo sapiens
90 RHOB 388
Proximity Label-MS Homo sapiens
91 SEMA4G  
Affinity Capture-MS Homo sapiens
92 KRAS 3845
Proximity Label-MS Homo sapiens
93 STYX  
Two-hybrid Homo sapiens
94 BMP1 649
Affinity Capture-MS Homo sapiens
95 DUSP18  
Two-hybrid Homo sapiens
96 MALL  
Affinity Capture-MS Homo sapiens
97 PRKD2 25865
Affinity Capture-MS Homo sapiens
98 ADAMTS7  
Affinity Capture-MS Homo sapiens
99 GLUD1 2746
Co-fractionation Homo sapiens
100 GRN 2896
Affinity Capture-MS Homo sapiens
101 IL17RB  
Affinity Capture-MS Homo sapiens
102 GP9 2815
Affinity Capture-MS Homo sapiens
103 EMC1 23065
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 EPHA4 2043
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
105 MISP 126353
Affinity Capture-MS Homo sapiens
106 PLXNA1 5361
Affinity Capture-MS Homo sapiens
107 TMEM30B 161291
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
108 COL18A1 80781
Affinity Capture-MS Homo sapiens
109 DNAJC5 80331
Proximity Label-MS Homo sapiens
110 GNB1 2782
Two-hybrid Homo sapiens
111 C11orf52 91894
Proximity Label-MS Homo sapiens
112 SEMA3B 7869
Affinity Capture-MS Homo sapiens
113 EPHA3 2042
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
114 MAP1LC3A 84557
Two-hybrid Homo sapiens
115 BRICD5  
Affinity Capture-MS Homo sapiens
116 HLA-DPA1  
Affinity Capture-MS Homo sapiens
117 RPL23 9349
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
118 LAMB2 3913
Affinity Capture-MS Homo sapiens
119 LAMA5 3911
Affinity Capture-MS Homo sapiens
120 EPHA2 1969
Affinity Capture-MS Homo sapiens
121 CACNG2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
122 COLGALT1 79709
Affinity Capture-MS Homo sapiens
123 CAV1 857
Proximity Label-MS Homo sapiens
124 WNT16  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml



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