Gene description for ADGRG1
Gene name adhesion G protein-coupled receptor G1
Gene symbol ADGRG1
Other names/aliases BFPP
BPPR
GPR56
TM7LN4
TM7XN1
Species Homo sapiens
 Database cross references - ADGRG1
ExoCarta ExoCarta_9289
Entrez Gene 9289
HGNC 4512
MIM 604110
UniProt Q9Y653  
 ADGRG1 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for ADGRG1
Molecular Function
    collagen binding GO:0005518 ISS
    G-protein coupled receptor activity GO:0004930 ISS
    extracellular matrix binding GO:0050840 ISS
Biological Process
    layer formation in cerebral cortex GO:0021819 ISS
    cell-cell signaling GO:0007267 TAS
    cell adhesion GO:0007155 IEA
    negative regulation of neuron migration GO:2001223 ISS
    protein kinase C signaling GO:0070528 IDA
    positive regulation of cell adhesion GO:0045785 IDA
    angiogenesis GO:0001525 IDA
    vascular endothelial growth factor production GO:0010573 IDA
    negative regulation of cell proliferation GO:0008285 IDA
    positive regulation of Rho protein signal transduction GO:0035025 ISS
    brain development GO:0007420 IMP
    Rho protein signal transduction GO:0007266 IDA
    cerebral cortex radial glia guided migration GO:0021801 ISS
    G-protein coupled receptor signaling pathway GO:0007186 IEA
Subcellular Localization
    integral component of plasma membrane GO:0005887 TAS
    glial limiting end-foot GO:0097451 ISS
    intracellular GO:0005622 IDA
    integral component of membrane GO:0016021 TAS
    extracellular exosome GO:0070062 IDA
 Experiment description of studies that identified ADGRG1 in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for ADGRG1
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which ADGRG1 is involved
No pathways found





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