Gene description for HLA-G
Gene name	major histocompatibility complex, class I, G
Gene symbol	HLA-G
Other names/aliases	MHC-G
Species	Homo sapiens
Database cross references - HLA-G
ExoCarta	ExoCarta_3135
Vesiclepedia	VP_3135
Entrez Gene	3135
HGNC	4964
MIM	142871
UniProt	P17693
HLA-G identified in sEVs derived from the following tissue/cell type
Bladder cancer cells	20224111
Malignant pleural effusions	14975938

Gene ontology annotations for HLA-G

Molecular Function     signaling receptor binding GO:0005102 IBA     signaling receptor binding GO:0005102 IPI     protein binding GO:0005515 IPI     peptide antigen binding GO:0042605 IBA     peptide antigen binding GO:0042605 IDA     CD8 receptor binding GO:0042610 IDA     identical protein binding GO:0042802 IPI     protein homodimerization activity GO:0042803 IDA Biological Process     negative regulation of T cell mediated cytotoxicity GO:0001915 IDA     positive regulation of T cell mediated cytotoxicity GO:0001916 IBA     peripheral B cell tolerance induction GO:0002451 IDA     antigen processing and presentation of endogenous peptide antigen via MHC class Ib GO:0002476 IBA     antigen processing and presentation of endogenous peptide antigen via MHC class Ib GO:0002476 IDA     antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent GO:0002486 IBA     positive regulation of tolerance induction GO:0002645 IMP     positive regulation of T cell tolerance induction GO:0002666 IMP     positive regulation of natural killer cell cytokine production GO:0002729 IDA     immune response-inhibiting cell surface receptor signaling pathway GO:0002767 IDA     immune response GO:0006955 IBA     cellular defense response GO:0006968 TAS     negative regulation of angiogenesis GO:0016525 IDA     positive regulation of interleukin-12 production GO:0032735 IDA     negative regulation of T cell proliferation GO:0042130 IDA     protection from natural killer cell mediated cytotoxicity GO:0042270 IDA     positive regulation of regulatory T cell differentiation GO:0045591 IMP     negative regulation of natural killer cell mediated cytotoxicity GO:0045953 IDA     negative regulation of natural killer cell mediated cytotoxicity GO:0045953 IMP     negative regulation of immune response GO:0050777 IC     negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction GO:0051898 IDA     positive regulation of macrophage cytokine production GO:0060907 IDA     protein homotrimerization GO:0070207 IDA     negative regulation of G0 to G1 transition GO:0070317 IDA     positive regulation of endothelial cell apoptotic process GO:2000353 IDA     positive regulation of cellular senescence GO:2000774 IDA     negative regulation of dendritic cell differentiation GO:2001199 IDA Subcellular Localization     Golgi membrane GO:0000139 TAS     extracellular space GO:0005615 IBA     early endosome GO:0005769 IDA     plasma membrane GO:0005886 IDA     plasma membrane GO:0005886 TAS     external side of plasma membrane GO:0009897 IBA     ER to Golgi transport vesicle membrane GO:0012507 TAS     membrane GO:0016020 HDA     phagocytic vesicle membrane GO:0030670 TAS     filopodium membrane GO:0031527 IEA     early endosome membrane GO:0031901 TAS     cis-Golgi network membrane GO:0033106 IDA     MHC class I protein complex GO:0042612 IEA     recycling endosome membrane GO:0055038 TAS     lumenal side of endoplasmic reticulum membrane GO:0098553 TAS