Gene description for CLSTN3
Gene name calsyntenin 3
Gene symbol CLSTN3
Other names/aliases CDHR14
CSTN3
alcbeta
Species Homo sapiens
 Database cross references - CLSTN3
ExoCarta ExoCarta_9746
Vesiclepedia VP_9746
Entrez Gene 9746
HGNC 18371
MIM 611324
UniProt Q9BQT9  
 CLSTN3 identified in exosomes derived from the following tissue/cell type
Chondrocytes 35931686    
Chondrocytes 35931686    
 Gene ontology annotations for CLSTN3
Molecular Function
    enzyme inhibitor activity GO:0004857 ISS
    calcium ion binding GO:0005509 IEA
    protein binding GO:0005515 IPI
    neurexin family protein binding GO:0042043 IDA
    neurexin family protein binding GO:0042043 ISS
    cell-cell adhesion mediator activity GO:0098632 IDA
    cell-cell adhesion mediator activity GO:0098632 ISS
Biological Process
    regulation of cell growth GO:0001558 IEA
    homophilic cell adhesion via plasma membrane adhesion molecules GO:0007156 IEA
    synapse assembly GO:0007416 IEA
    protein secretion GO:0009306 ISS
    negative regulation of lipid storage GO:0010888 ISS
    L-ascorbic acid metabolic process GO:0019852 IDA
    synaptic transmission, glutamatergic GO:0035249 IEA
    positive regulation of synaptic transmission GO:0050806 IBA
    positive regulation of lipid catabolic process GO:0050996 ISS
    synaptic transmission, GABAergic GO:0051932 IEA
    regulation of synapse assembly GO:0051963 IDA
    positive regulation of synapse assembly GO:0051965 IBA
    sympathetic neuron projection extension GO:0097490 ISS
    cell-cell adhesion GO:0098609 IEA
    cold-induced thermogenesis GO:0106106 ISS
    negative regulation of lipid droplet fusion GO:0160078 ISS
    positive regulation of protein localization to synapse GO:1902474 IEA
    excitatory synapse assembly GO:1904861 ISS
    inhibitory synapse assembly GO:1904862 ISS
    regulation of excitatory synapse assembly GO:1904889 ISS
    negative regulation of excitatory synapse assembly GO:1904890 ISS
    regulation of presynapse assembly GO:1905606 IEA
    positive regulation of inhibitory synapse assembly GO:1905704 ISS
    adaptive thermogenesis GO:1990845 ISS
Subcellular Localization
    Golgi membrane GO:0000139 IEA
    endoplasmic reticulum membrane GO:0005789 IEA
    endoplasmic reticulum membrane GO:0005789 ISS
    lipid droplet GO:0005811 IEA
    lipid droplet GO:0005811 ISS
    cell surface GO:0009986 IBA
    dendrite GO:0030425 IEA
    protein-containing complex GO:0032991 IEA
    organelle membrane contact site GO:0044232 ISS
    postsynaptic membrane GO:0045211 IBA
    postsynaptic density membrane GO:0098839 IEA
    glutamatergic synapse GO:0098978 IEA
    GABA-ergic synapse GO:0098982 IEA
 Experiment description of studies that identified CLSTN3 in exosomes
1
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 498
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for CLSTN3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LY86  
Affinity Capture-MS Homo sapiens
2 UPK2 7379
Affinity Capture-MS Homo sapiens
3 ADAM30 11085
Affinity Capture-MS Homo sapiens
4 ASIC4  
Affinity Capture-MS Homo sapiens
5 GPIHBP1  
Affinity Capture-MS Homo sapiens
6 CD1A 909
Affinity Capture-MS Homo sapiens
7 CMTM7  
Two-hybrid Homo sapiens
8 CA14 23632
Affinity Capture-MS Homo sapiens
9 TMEM106A  
Affinity Capture-MS Homo sapiens
10 KLK15  
Affinity Capture-MS Homo sapiens
11 PCDHB7  
Affinity Capture-MS Homo sapiens
12 CNTNAP3  
Affinity Capture-MS Homo sapiens
13 TMEM107 84314
Two-hybrid Homo sapiens
14 HLA-G 3135
Affinity Capture-MS Homo sapiens
15 KLK5 25818
Affinity Capture-MS Homo sapiens
16 UQCC1 55245
Affinity Capture-MS Homo sapiens
17 NRSN1  
Affinity Capture-MS Homo sapiens
18 CMA1  
Affinity Capture-MS Homo sapiens
19 CHST8 64377
Affinity Capture-MS Homo sapiens
20 GZMH  
Affinity Capture-MS Homo sapiens
21 CLEC2D  
Affinity Capture-MS Homo sapiens
22 B3GNT3 10331
Affinity Capture-MS Homo sapiens
23 TMEM54  
Two-hybrid Homo sapiens
24 PRG2  
Affinity Capture-MS Homo sapiens
25 ECEL1  
Affinity Capture-MS Homo sapiens
26 APBA3  
Affinity Capture-MS Homo sapiens
27 CBLN4  
Affinity Capture-MS Homo sapiens
28 ST3GAL4 6484
Affinity Capture-MS Homo sapiens
29 PGAP2  
Two-hybrid Homo sapiens
30 B3GAT2  
Affinity Capture-MS Homo sapiens
31 OLFM4 10562
Two-hybrid Homo sapiens
32 APOM 55937
Affinity Capture-MS Homo sapiens
33 MAL  
Two-hybrid Homo sapiens
34 NXF1 10482
Affinity Capture-RNA Homo sapiens
35 SFTPC  
Affinity Capture-MS Homo sapiens
36 APEX1 328
Affinity Capture-RNA Homo sapiens
37 CTSG 1511
Affinity Capture-MS Homo sapiens
38 CLEC12B  
Affinity Capture-MS Homo sapiens
39 CGB  
Affinity Capture-MS Homo sapiens
40 TNFSF13 8741
Affinity Capture-MS Homo sapiens
41 ADAMTS12 81792
Affinity Capture-MS Homo sapiens
42 HLA-DRB3 3125
Affinity Capture-MS Homo sapiens
43 SDF2L1 23753
Affinity Capture-MS Homo sapiens
44 ZDHHC22  
Two-hybrid Homo sapiens
45 TRGV3  
Affinity Capture-MS Homo sapiens
46 ITM2C 81618
Affinity Capture-MS Homo sapiens
47 TCTN2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 GXYLT1 283464
Affinity Capture-MS Homo sapiens
49 CDHR4  
Affinity Capture-MS Homo sapiens
50 CLEC2B  
Affinity Capture-MS Homo sapiens
51 EDN3  
Affinity Capture-MS Homo sapiens
52 P2RX2  
Affinity Capture-MS Homo sapiens
53 SCNN1D  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 HLA-DQB1 3119
Affinity Capture-MS Homo sapiens
55 ST8SIA5  
Affinity Capture-MS Homo sapiens
56 HLA-DRB1 3123
Affinity Capture-MS Homo sapiens
57 NKG7  
Two-hybrid Homo sapiens
58 CFC1  
Affinity Capture-MS Homo sapiens
59 TMEM97 27346
Two-hybrid Homo sapiens
60 HLA-C 3107
Affinity Capture-MS Homo sapiens
61 ST8SIA4 7903
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 TRAM1L1  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which CLSTN3 is involved
No pathways found





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here