Gene description for ST3GAL4
Gene name ST3 beta-galactoside alpha-2,3-sialyltransferase 4
Gene symbol ST3GAL4
Other names/aliases CGS23
NANTA3
SAT3
SIAT4
SIAT4C
ST3GalIV
STZ
Species Homo sapiens
 Database cross references - ST3GAL4
ExoCarta ExoCarta_6484
Entrez Gene 6484
HGNC 10864
MIM 104240
UniProt Q11206  
 ST3GAL4 identified in exosomes derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for ST3GAL4
Molecular Function
    monosialoganglioside sialyltransferase activity GO:0047288 IEA
    beta-galactoside (CMP) alpha-2,3-sialyltransferase activity GO:0003836 IEA
Biological Process
    dolichol-linked oligosaccharide biosynthetic process GO:0006488 TAS
    O-glycan processing GO:0016266 TAS
    small molecule metabolic process GO:0044281 TAS
    glycosaminoglycan metabolic process GO:0030203 TAS
    cognition GO:0050890 IMP
    post-translational protein modification GO:0043687 TAS
    protein N-linked glycosylation via asparagine GO:0018279 TAS
    keratan sulfate biosynthetic process GO:0018146 TAS
    carbohydrate metabolic process GO:0005975 TAS
    sialylation GO:0097503 TAS
    keratan sulfate metabolic process GO:0042339 TAS
    protein O-linked glycosylation GO:0006493 TAS
    cellular protein metabolic process GO:0044267 TAS
Subcellular Localization
    extracellular exosome GO:0070062 IDA
    Golgi cisterna membrane GO:0032580 IEA
    Golgi membrane GO:0000139 TAS
    integral component of Golgi membrane GO:0030173 IEA
    membrane GO:0016020 IDA
 Experiment description of studies that identified ST3GAL4 in exosomes
1
Experiment ID 237
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for ST3GAL4
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here