Gene description for PON2
Gene name paraoxonase 2
Gene symbol PON2
Other names/aliases -
Species Homo sapiens
 Database cross references - PON2
ExoCarta ExoCarta_5445
Vesiclepedia VP_5445
Entrez Gene 5445
HGNC 9205
MIM 602447
UniProt Q15165  
 PON2 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for PON2
Molecular Function
    arylesterase activity GO:0004064 IBA
    protein binding GO:0005515 IPI
    protein homodimerization activity GO:0042803 IPI
    metal ion binding GO:0046872 IEA
    acyl-L-homoserine-lactone lactonohydrolase activity GO:0102007 IDA
Biological Process
    response to toxic substance GO:0009636 IBA
    lactone catabolic process GO:1901335 IDA
Subcellular Localization
    extracellular region GO:0005576 TAS
    plasma membrane GO:0005886 IDA
 Experiment description of studies that identified PON2 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PON2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 POMT2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 P4HA1 5033
Co-fractionation Homo sapiens
3 POR 5447
Co-fractionation Homo sapiens
4 KLK15  
Affinity Capture-MS Homo sapiens
5 CACNA2D1 781
Affinity Capture-MS Homo sapiens
6 SCNN1A  
Affinity Capture-MS Homo sapiens
7 NDUFS1 4719
Co-fractionation Homo sapiens
8 KLK5 25818
Affinity Capture-MS Homo sapiens
9 TPP1 1200
Co-fractionation Homo sapiens
10 CHST14 113189
Affinity Capture-MS Homo sapiens
11 ADRB2  
Affinity Capture-MS Homo sapiens
12 Atp2a2 11938
Affinity Capture-MS Mus musculus
13 STRN3 29966
Affinity Capture-MS Homo sapiens
14 C9orf78 51759
Affinity Capture-MS Homo sapiens
15 SULF2 55959
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 KLRB1  
Affinity Capture-MS Homo sapiens
17 Ktn1  
Affinity Capture-MS Mus musculus
18 ST6GALNAC3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 CDC6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
20 POMGNT2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 C1QL4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
22 AMIGO1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
23 LRPPRC 10128
Co-fractionation Homo sapiens
24 KIAA1429 25962
Affinity Capture-MS Homo sapiens
25 TM2D3  
Affinity Capture-MS Homo sapiens
26 Kcnk1  
Affinity Capture-MS Mus musculus
27 NDUFS3 4722
Co-fractionation Homo sapiens
28 PCNT  
Affinity Capture-MS Homo sapiens
29 FAM150B  
Affinity Capture-MS Homo sapiens
30 TGFB1 7040
Affinity Capture-MS Homo sapiens
31 PPP2R5D 5528
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 GPATCH8  
Affinity Capture-MS Homo sapiens
33 CARKD 55739
Affinity Capture-MS Homo sapiens
34 SPRTN  
Affinity Capture-MS Homo sapiens
35 SLC39A11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
36 TRABD 80305
Affinity Capture-MS Homo sapiens
37 NETO2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 HYAL2 8692
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 CLEC2B  
Affinity Capture-MS Homo sapiens
40 KLRC1  
Affinity Capture-MS Homo sapiens
41 ST8SIA5  
Affinity Capture-MS Homo sapiens
42 LONP1 9361
Co-fractionation Homo sapiens
43 RHOA 387
Co-fractionation Homo sapiens
44 CTSF 8722
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 SCARB1 949
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 ENPP1 5167
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
47 COMT 1312
Co-fractionation Homo sapiens
48 ST8SIA4 7903
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 NDUFV1 4723
Co-fractionation Homo sapiens
50 CANX 821
Affinity Capture-MS Homo sapiens
51 KLRC2  
Affinity Capture-MS Homo sapiens
52 CA14 23632
Affinity Capture-MS Homo sapiens
53 TMEM106A  
Affinity Capture-MS Homo sapiens
54 ISLR 3671
Affinity Capture-MS Homo sapiens
55 HK1 3098
Co-fractionation Homo sapiens
56 CLEC2D  
Affinity Capture-MS Homo sapiens
57 HLA-G 3135
Affinity Capture-MS Homo sapiens
58 NXPH4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
59 PRELP 5549
Affinity Capture-MS Homo sapiens
60 CHST12 55501
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 CACNA2D2 9254
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
62 NNT 23530
Co-fractionation Homo sapiens
63 TMEM25  
Affinity Capture-MS Homo sapiens
64 EXTL3 2137
Affinity Capture-MS Homo sapiens
65 MOXD1 26002
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
66 CNNM1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 HS2ST1 9653
Affinity Capture-MS Homo sapiens
68 NPC1 4864
Affinity Capture-MS Homo sapiens
69 ITGA6 3655
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 MAGEA10  
Affinity Capture-MS Homo sapiens
71 LRIG2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 ERBB3 2065
Affinity Capture-MS Homo sapiens
73 STOM 2040
Co-fractionation Homo sapiens
74 LINGO1 84894
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
75 UGT8  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 TMEM219  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
77 TNFSF13 8741
Affinity Capture-MS Homo sapiens
78 SMOC1 64093
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
79 CHST8 64377
Affinity Capture-MS Homo sapiens
80 VCP 7415
Co-fractionation Homo sapiens
81 PTP4A2 8073
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 SAR1B 51128
Affinity Capture-MS Homo sapiens
83 RAP1A 5906
Co-fractionation Homo sapiens
84 RDH11 51109
Affinity Capture-MS Homo sapiens
85 CDHR4  
Affinity Capture-MS Homo sapiens
86 CYC1 1537
Co-fractionation Homo sapiens
87 UQCRC1 7384
Co-fractionation Homo sapiens
88 UGT1A9  
Affinity Capture-MS Homo sapiens
89 ITGA4 3676
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
90 B4GALT3 8703
Affinity Capture-MS Homo sapiens
91 ART5  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
92 PGAP1 80055
Affinity Capture-MS Homo sapiens
93 CCDC47 57003
Affinity Capture-MS Homo sapiens
94 RNF167 26001
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
95 RER1 11079
Affinity Capture-MS Homo sapiens
96 UST  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
97 RNF130  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
98 UBR2 23304
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
99 UPK2 7379
Affinity Capture-MS Homo sapiens
100 CACHD1  
Affinity Capture-MS Homo sapiens
101 HSPA5 3309
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
102 TMEM30A 55754
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
103 PCDH20  
Affinity Capture-MS Homo sapiens
104 CUL3 8452
Affinity Capture-MS Homo sapiens
105 Nup98  
Affinity Capture-MS Mus musculus
106 BCKDHB 594
Co-fractionation Homo sapiens
107 LRRC59 55379
Proximity Label-MS Homo sapiens
108 NDUFA9 4704
Co-fractionation Homo sapiens
109 RNF170 81790
Affinity Capture-MS Homo sapiens
110 B4GALT1 2683
Affinity Capture-MS Homo sapiens
111 CMA1  
Affinity Capture-MS Homo sapiens
112 UQCRC2 7385
Co-fractionation Homo sapiens
113 B3GNT3 10331
Affinity Capture-MS Homo sapiens
114 PRG2  
Affinity Capture-MS Homo sapiens
115 LRFN3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
116 ATP6AP2 10159
Affinity Capture-MS Homo sapiens
117 NR3C1 2908
Proximity Label-MS Homo sapiens
118 RLN1  
Affinity Capture-MS Homo sapiens
119 EGFR 1956
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
120 FBXO6 26270
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
121 CNTNAP3B  
Affinity Capture-MS Homo sapiens
122 HLA-DQA1 3117
Affinity Capture-MS Homo sapiens
123 LRIG1 26018
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
124 ATP6V1A 523
Co-fractionation Homo sapiens
125 A4GNT  
Affinity Capture-MS Homo sapiens
126 IMPAD1 54928
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
127 DNAJC3 5611
Affinity Capture-MS Homo sapiens
128 M6PR 4074
Affinity Capture-MS Homo sapiens
129 ABCA2 20
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
130 RNF128  
Affinity Capture-MS Homo sapiens
131 HLA-DQB1 3119
Affinity Capture-MS Homo sapiens
132 LRP11  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
133 POGLUT1 56983
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
134 BMP1 649
Affinity Capture-MS Homo sapiens
135 ST3GAL6 10402
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
136 ST3GAL5  
Affinity Capture-MS Homo sapiens
137 ADAM30 11085
Affinity Capture-MS Homo sapiens
138 MR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
139 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
140 Tubg1 103733
Affinity Capture-MS Mus musculus
141 GRB2 2885
Two-hybrid Homo sapiens
142 TXNDC15  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
143 PTRF 284119
Co-fractionation Homo sapiens
144 RUVBL2 10856
Affinity Capture-MS Homo sapiens
145 UVSSA  
Affinity Capture-MS Homo sapiens
146 EMC1 23065
Affinity Capture-MS Homo sapiens
147 ASIC4  
Affinity Capture-MS Homo sapiens
148 HNRNPA2B1 3181
Cross-Linking-MS (XL-MS) Homo sapiens
149 CHST10  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
150 CD1A 909
Affinity Capture-MS Homo sapiens
151 SIL1 64374
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
152 INSR 3643
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
153 NUP35 129401
Proximity Label-MS Homo sapiens
154 ATP2A2 488
Co-fractionation Homo sapiens
155 SFTPC  
Affinity Capture-MS Homo sapiens
156 GZMH  
Affinity Capture-MS Homo sapiens
157 TAZ  
Affinity Capture-MS Homo sapiens
158 ST3GAL4 6484
Affinity Capture-MS Homo sapiens
159 DNASE2B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
160 SPPL2B 56928
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
161 ZNRF4  
Affinity Capture-MS Homo sapiens
162 ENTPD6  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
163 TCF3  
Affinity Capture-MS Homo sapiens
164 LAMB3 3914
Affinity Capture-MS Homo sapiens
165 MARCH4  
Affinity Capture-MS Homo sapiens
166 B3GNT2 10678
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
167 LMLN  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
168 HLA-DRB1 3123
Affinity Capture-MS Homo sapiens
169 CHSY1 22856
Affinity Capture-MS Homo sapiens
170 ANKRD46 157567
Affinity Capture-MS Homo sapiens
171 ARSK  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
172 TRAV20  
Affinity Capture-MS Homo sapiens
173 HS6ST2 90161
Affinity Capture-MS Homo sapiens
174 B3GNT7  
Affinity Capture-MS Homo sapiens
175 HLA-C 3107
Affinity Capture-MS Homo sapiens
176 GPAT2  
Affinity Capture-MS Homo sapiens
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