Gene description for RNF167
Gene name ring finger protein 167
Gene symbol RNF167
Other names/aliases 5730408C10Rik
LP2254
RING105
Species Homo sapiens
 Database cross references - RNF167
ExoCarta ExoCarta_26001
Vesiclepedia VP_26001
Entrez Gene 26001
HGNC 24544
MIM 610431
UniProt Q9H6Y7  
 RNF167 identified in sEVs derived from the following tissue/cell type
Hepatocytes 26054723    
 Gene ontology annotations for RNF167
Molecular Function
    ubiquitin-protein transferase activity GO:0004842 IDA
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IEA
    ubiquitin protein ligase activity GO:0061630 IBA
    ubiquitin protein ligase activity GO:0061630 IDA
Biological Process
    protein polyubiquitination GO:0000209 IDA
    ubiquitin-dependent protein catabolic process GO:0006511 IBA
    ubiquitin-dependent protein catabolic process GO:0006511 IDA
    lysosome localization GO:0032418 IDA
    lysosome localization GO:0032418 IDA
    protein K29-linked ubiquitination GO:0035519 IDA
    negative regulation of cell cycle GO:0045786 IBA
    negative regulation of cell cycle GO:0045786 IMP
    organelle localization GO:0051640 IMP
    regulation of synaptic transmission, glutamatergic GO:0051966 IDA
    protein K63-linked ubiquitination GO:0070534 IDA
    negative regulation of TORC1 signaling GO:1904262 IDA
    positive regulation of TORC1 signaling GO:1904263 IDA
    cellular response to leucine starvation GO:1990253 IDA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    lysosome GO:0005764 IDA
    lysosomal membrane GO:0005765 IDA
    endosome GO:0005768 IDA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 IEA
    plasma membrane GO:0005886 IEA
    endolysosome membrane GO:0036020 IDA
 Experiment description of studies that identified RNF167 in sEVs
1
Experiment ID 237
MISEV standards
EM
Biophysical techniques
TSG101|Alix|HSC70|GAPDH
Enriched markers
HSP90B1
Negative markers
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
 Protein-protein interactions for RNF167
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 AP3S1 1176
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 MAGEA8  
Affinity Capture-MS Homo sapiens
3 HFE  
Affinity Capture-MS Homo sapiens
4 UBE2W  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
5 FAM19A2 338811
Reconstituted Complex Homo sapiens
6 UBE2N 7334
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
7 KLRC3  
Affinity Capture-MS Homo sapiens
8 UBE2A  
Reconstituted Complex Homo sapiens
9 CHRNA4  
Affinity Capture-MS Homo sapiens
10 UBE2K 3093
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
11 RNF167 26001
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
12 CCDC59  
Affinity Capture-MS Homo sapiens
13 TMPRSS11B 132724
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
14 SRPRB 58477
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 UBE2E3 10477
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
16 PON2 5445
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 LGALS3 3958
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 CD1A 909
Affinity Capture-MS Homo sapiens
19 MDK 4192
Reconstituted Complex Homo sapiens
20 GATSL3 652968
Affinity Capture-Western Homo sapiens
21 UBE2T  
Reconstituted Complex Homo sapiens
22 UBE2C 11065
Reconstituted Complex Homo sapiens
23 B4GAT1 11041
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 UBE2D4  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
25 PTN  
Reconstituted Complex Homo sapiens
26 CDC34 997
Reconstituted Complex Homo sapiens
27 UBE2G2  
Reconstituted Complex Homo sapiens
28 APEX1 328
Affinity Capture-RNA Homo sapiens
29 UBE2D2 7322
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
30 SESN2 83667
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
Reconstituted Complex Homo sapiens
31 HLA-DPA1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 UBE2E1  
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
33 A4GNT  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 FAM19A5 25817
Reconstituted Complex Homo sapiens
35 LAMP1 3916
Affinity Capture-MS Homo sapiens
36 RNF13 11342
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
37 UBE2D3 7323
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
38 KLRC1  
Affinity Capture-MS Homo sapiens
39 UBE2B 7320
Reconstituted Complex Homo sapiens
40 GRIA2  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
41 SLC22A18 5002
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Biochemical Activity Homo sapiens
42 IL17RC 84818
Affinity Capture-MS Homo sapiens
43 UBE2D1 7321
Two-hybrid Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which RNF167 is involved
No pathways found





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