Gene description for GATSL3
Gene name GATS protein-like 3
Gene symbol GATSL3
Other names/aliases -
Species Homo sapiens
 Database cross references - GATSL3
ExoCarta ExoCarta_652968
Vesiclepedia VP_652968
Entrez Gene 652968
HGNC 34423
UniProt Q8WTX7  
 GATSL3 identified in sEVs derived from the following tissue/cell type
Urine 19056867    
 Gene ontology annotations for GATSL3
Molecular Function
    protein binding GO:0005515 IPI
    arginine binding GO:0034618 IBA
    arginine binding GO:0034618 IDA
    identical protein binding GO:0042802 IDA
    identical protein binding GO:0042802 IPI
    molecular sensor activity GO:0140299 IDA
    protein sequestering activity GO:0140311 IDA
Biological Process
    cellular response to amino acid starvation GO:0034198 IDA
    cellular response to L-arginine GO:1903577 IBA
    cellular response to L-arginine GO:1903577 IDA
    cellular response to L-arginine GO:1903577 IMP
    negative regulation of TORC1 signaling GO:1904262 IBA
    negative regulation of TORC1 signaling GO:1904262 IDA
    negative regulation of TORC1 signaling GO:1904262 IMP
    positive regulation of TORC1 signaling GO:1904263 IDA
Subcellular Localization
    cytosol GO:0005829 IBA
    cytosol GO:0005829 IDA
    cytosol GO:0005829 TAS
    GATOR2 complex GO:0061700 IDA
 Experiment description of studies that identified GATSL3 in sEVs
1
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for GATSL3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 WDR59 79726
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
2 ZC2HC1B  
Two-hybrid Homo sapiens
3 GATSL3 652968
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
4 TMA16  
Two-hybrid Homo sapiens
5 RARRES3  
Affinity Capture-MS Homo sapiens
6 MIOS 54468
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
7 AKT1 207
Biochemical Activity Homo sapiens
8 IFIT2 3433
Affinity Capture-MS Homo sapiens
9 ZC2HC1A 51101
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 GATSL2  
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 WDR24  
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
12 RNF167 26001
Affinity Capture-Western Homo sapiens
13 RXRA 6256
Affinity Capture-MS Homo sapiens
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