Gene description for IFIT2
Gene name interferon-induced protein with tetratricopeptide repeats 2
Gene symbol IFIT2
Other names/aliases G10P2
GARG-39
IFI-54
IFI-54K
IFI54
IFIT-2
ISG-54 K
ISG-54K
ISG54
P54
cig42
Species Homo sapiens
 Database cross references - IFIT2
ExoCarta ExoCarta_3433
Entrez Gene 3433
HGNC 5409
MIM 147040
UniProt P09913  
 IFIT2 identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for IFIT2
Molecular Function
    poly(A) RNA binding GO:0044822 IDA
    protein binding GO:0005515 IPI
Biological Process
    positive regulation of apoptotic process GO:0043065 IDA
    negative regulation of protein binding GO:0032091 IDA
    response to virus GO:0009615 IMP
    defense response to virus GO:0051607 IEA
    cytokine-mediated signaling pathway GO:0019221 TAS
    apoptotic mitochondrial changes GO:0008637 TAS
    cellular response to interferon-alpha GO:0035457 IEA
    type I interferon signaling pathway GO:0060337 TAS
Subcellular Localization
    cytosol GO:0005829 TAS
    cytoplasm GO:0005737 IDA
    endoplasmic reticulum GO:0005783 IDA
 Experiment description of studies that identified IFIT2 in exosomes
1
Experiment ID 226
ISEV standards
✔
EM
EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✔
CD9|FLOT1
EV Membrane markers
✔
LMNA|H2AFX|ATP5A1|TOMM20
EV Negative markers
✘ EV Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting
Authors Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
2
Experiment ID 226
ISEV standards
✔
EM
EV Biophysical techniques
✔
GAPDH
EV Cytosolic markers
✔
CD9|FLOT1
EV Membrane markers
✔
LMNA|H2AFX|ATP5A1|TOMM20
EV Negative markers
✘ EV Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting
Authors Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for IFIT2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 IFIT3 3437
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which IFIT2 is involved
PathwayEvidenceSource
Interferon alpha/beta signaling TAS Reactome





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