Gene description for SNRPC
Gene name small nuclear ribonucleoprotein polypeptide C
Gene symbol SNRPC
Other names/aliases U1C
Yhc1
Species Homo sapiens
 Database cross references - SNRPC
ExoCarta ExoCarta_6631
Vesiclepedia VP_6631
Entrez Gene 6631
HGNC 11157
MIM 603522
UniProt P09234  
 SNRPC identified in exosomes derived from the following tissue/cell type
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
 Gene ontology annotations for SNRPC
Molecular Function
    RNA binding GO:0003723 HDA
    single-stranded RNA binding GO:0003727 IDA
    mRNA binding GO:0003729 IEA
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 IDA
    U1 snRNA binding GO:0030619 IDA
    pre-mRNA 5'-splice site binding GO:0030627 IBA
    protein homodimerization activity GO:0042803 IPI
Biological Process
    spliceosomal snRNP assembly GO:0000387 IDA
    mRNA 5'-splice site recognition GO:0000395 IBA
    mRNA splicing, via spliceosome GO:0000398 IDA
    mRNA splicing, via spliceosome GO:0000398 NAS
Subcellular Localization
    commitment complex GO:0000243 IEA
    nucleus GO:0005634 NAS
    nucleoplasm GO:0005654 IDA
    nucleoplasm GO:0005654 TAS
    spliceosomal complex GO:0005681 IPI
    U1 snRNP GO:0005685 IBA
    U1 snRNP GO:0005685 IDA
    U1 snRNP GO:0005685 IPI
    Cajal body GO:0015030 IDA
    U2-type prespliceosome GO:0071004 IEA
 Experiment description of studies that identified SNRPC in exosomes
1
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
3
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for SNRPC
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PQBP1  
Affinity Capture-MS Homo sapiens
2 RPP40 10799
Affinity Capture-MS Homo sapiens
3 RBPMS 11030
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
4 PRPF8 10594
Affinity Capture-MS Homo sapiens
5 SRPK2 6733
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 AES 166
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
7 DDX17 10521
Affinity Capture-MS Homo sapiens
8 CDC25B 994
Affinity Capture-MS Homo sapiens
9 HNRNPC 3183
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 THOC7 80145
Affinity Capture-MS Homo sapiens
11 SCAF4 57466
Affinity Capture-MS Homo sapiens
12 PRPF40A 55660
Affinity Capture-MS Homo sapiens
13 AKAP8L  
Affinity Capture-MS Homo sapiens
14 DDX23 9416
Affinity Capture-MS Homo sapiens
15 IGF2BP3 10643
Affinity Capture-MS Homo sapiens
16 SNRNP70 6625
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 CRNKL1 51340
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
18 KIF23 9493
Affinity Capture-MS Homo sapiens
19 MATR3 9782
Co-fractionation Homo sapiens
20 USP39 10713
Affinity Capture-MS Homo sapiens
21 AGGF1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
22 CPSF7 79869
Two-hybrid Homo sapiens
23 KRT31 3881
Two-hybrid Homo sapiens
24 SNRPD3 6634
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
25 POLR2C 5432
Affinity Capture-MS Homo sapiens
26 MECP2 4204
Affinity Capture-MS Homo sapiens
27 ARIH2 10425
Affinity Capture-MS Homo sapiens
28 GNPAT 8443
Affinity Capture-MS Homo sapiens
29 SREK1 140890
Affinity Capture-MS Homo sapiens
30 KIF14 9928
Affinity Capture-MS Homo sapiens
31 RBMX 27316
Affinity Capture-MS Homo sapiens
32 RPP14  
Affinity Capture-MS Homo sapiens
33 NCKIPSD 51517
Two-hybrid Homo sapiens
34 SRPRB 58477
Co-fractionation Homo sapiens
35 SUPT5H 6829
Affinity Capture-MS Homo sapiens
36 CSTF2 1478
Affinity Capture-MS Homo sapiens
37 C17orf85  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
38 RBM7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
39 PPIH 10465
Affinity Capture-MS Homo sapiens
40 DDX20 11218
Affinity Capture-MS Homo sapiens
41 CARM1 10498
Co-fractionation Homo sapiens
42 SYNCRIP 10492
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 CUL2 8453
Affinity Capture-MS Homo sapiens
44 SRPK3  
Affinity Capture-MS Homo sapiens
45 SON 6651
Affinity Capture-MS Homo sapiens
46 DDX39B 7919
Affinity Capture-MS Homo sapiens
47 SRPK1 6732
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
48 TRA2B 6434
Affinity Capture-MS Homo sapiens
49 STH  
Two-hybrid Homo sapiens
50 CCDC12  
Affinity Capture-MS Homo sapiens
51 ZNF326 284695
Affinity Capture-MS Homo sapiens
52 BCLAF1 9774
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 DDX5 1655
Affinity Capture-MS Homo sapiens
54 SUGP1  
Affinity Capture-MS Homo sapiens
55 Rbm38  
Two-hybrid Mus musculus
56 CD2BP2 10421
Affinity Capture-MS Homo sapiens
57 KLF1  
Two-hybrid Homo sapiens
58 PRR20D  
Two-hybrid Homo sapiens
59 POLR2D  
Affinity Capture-MS Homo sapiens
60 WDR37 22884
Affinity Capture-MS Homo sapiens
61 ZC3H11A  
Affinity Capture-MS Homo sapiens
62 STRAP 11171
Affinity Capture-MS Homo sapiens
63 YTHDC1  
Affinity Capture-MS Homo sapiens
64 GEMIN4 50628
Affinity Capture-MS Homo sapiens
65 PRR20B  
Two-hybrid Homo sapiens
66 MFAP1  
Affinity Capture-MS Homo sapiens
67 APOBEC3F 200316
Affinity Capture-MS Homo sapiens
68 RPA3 6119
Proximity Label-MS Homo sapiens
69 GIGYF1  
Two-hybrid Homo sapiens
70 SF3B6 51639
Affinity Capture-MS Homo sapiens
71 THY1 7070
Co-fractionation Homo sapiens
72 SUPT16H 11198
Affinity Capture-MS Homo sapiens
73 PAXBP1  
Affinity Capture-MS Homo sapiens
74 YBX1 4904
Affinity Capture-MS Homo sapiens
75 CHTOP  
Affinity Capture-MS Homo sapiens
76 CTR9 9646
Affinity Capture-MS Homo sapiens
77 BCAS2 10286
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
78 WDR77 79084
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
79 POLR2J  
Affinity Capture-MS Homo sapiens
80 PRDM14  
Two-hybrid Homo sapiens
81 MACF1 23499
Affinity Capture-MS Homo sapiens
82 RBM25 58517
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
83 WWOX 51741
Two-hybrid Homo sapiens
84 ZMAT2  
Affinity Capture-MS Homo sapiens
85 APOBEC3D  
Affinity Capture-MS Homo sapiens
86 SRSF9 8683
Affinity Capture-MS Homo sapiens
87 JMJD7  
Two-hybrid Homo sapiens
88 WRAP53  
Co-fractionation Homo sapiens
89 PHF3  
Affinity Capture-MS Homo sapiens
90 SUPT4H1  
Affinity Capture-MS Homo sapiens
91 TCERG1 10915
Affinity Capture-MS Homo sapiens
92 CPSF2 53981
Affinity Capture-MS Homo sapiens
93 WWP2 11060
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
94 LARP7 51574
Affinity Capture-MS Homo sapiens
95 IK 3550
Affinity Capture-MS Homo sapiens
96 ALYREF 10189
Affinity Capture-MS Homo sapiens
97 HNRNPL 3191
Affinity Capture-MS Homo sapiens
98 SUPT6H 6830
Affinity Capture-MS Homo sapiens
99 PRPF4 9128
Affinity Capture-MS Homo sapiens
100 SNW1 22938
Affinity Capture-MS Homo sapiens
101 ECM1 1893
Two-hybrid Homo sapiens
102 SNRPA1 6627
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
103 LUC7L 55692
Affinity Capture-MS Homo sapiens
104 IFIT2 3433
Affinity Capture-MS Homo sapiens
105 EXOSC8  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
106 HNRNPH1 3187
Two-hybrid Homo sapiens
107 RBMXL1  
Affinity Capture-MS Homo sapiens
108 NCBP1 4686
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
109 RBM22 55696
Affinity Capture-MS Homo sapiens
110 TARDBP 23435
Affinity Capture-MS Homo sapiens
111 RPA2 6118
Proximity Label-MS Homo sapiens
112 PRPF38A 84950
Affinity Capture-MS Homo sapiens
113 QKI 9444
Two-hybrid Homo sapiens
114 MGAT5B  
Two-hybrid Homo sapiens
115 ARL6IP4  
Affinity Capture-MS Homo sapiens
116 ZFR 51663
Affinity Capture-MS Homo sapiens
117 CAND1 55832
Affinity Capture-MS Homo sapiens
118 KRTAP7-1  
Two-hybrid Homo sapiens
119 SNRPF 6636
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
120 SAFB 6294
Affinity Capture-MS Homo sapiens
121 RNPS1 10921
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
122 COPS6 10980
Affinity Capture-MS Homo sapiens
123 WDR83  
Two-hybrid Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Two-hybrid Homo sapiens
124 PRC1 9055
Affinity Capture-MS Homo sapiens
125 SRRM2 23524
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
126 KHDRBS1 10657
Affinity Capture-MS Homo sapiens
127 TOMM40 10452
Co-fractionation Homo sapiens
128 CUL1 8454
Affinity Capture-MS Homo sapiens
129 LSM2 57819
Affinity Capture-MS Homo sapiens
130 RUNX1  
Two-hybrid Homo sapiens
131 KRTAP22-1  
Two-hybrid Homo sapiens
132 HNRNPA0 10949
Affinity Capture-MS Homo sapiens
133 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
134 DDX21 9188
Affinity Capture-MS Homo sapiens
135 FHL3 2275
Two-hybrid Homo sapiens
136 ZNF207 7756
Affinity Capture-MS Homo sapiens
137 STOM 2040
Co-fractionation Homo sapiens
138 TRA2A 29896
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
139 ACIN1 22985
Affinity Capture-MS Homo sapiens
140 SNRNP200 23020
Affinity Capture-MS Homo sapiens
141 IWS1  
Affinity Capture-MS Homo sapiens
142 KRTAP6-2  
Two-hybrid Homo sapiens
143 SNRPD1 6632
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
144 TOX4  
Affinity Capture-MS Homo sapiens
145 SCAF11  
Affinity Capture-MS Homo sapiens
146 MAGOH 4116
Affinity Capture-MS Homo sapiens
147 MKRN3  
Two-hybrid Homo sapiens
148 SS18L1  
Two-hybrid Homo sapiens
149 TXNL4A 10907
Affinity Capture-MS Homo sapiens
150 SNRPB2 6629
Affinity Capture-MS Homo sapiens
151 ZCCHC8 55596
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
152 HNRNPD 3184
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
153 SPAG8  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
154 PSMA3 5684
Two-hybrid Homo sapiens
155 LEO1 123169
Affinity Capture-MS Homo sapiens
156 RC3H2  
Affinity Capture-MS Homo sapiens
157 NCAPH2  
Two-hybrid Homo sapiens
158 KIN  
Affinity Capture-MS Homo sapiens
159 SNRNP40 9410
Affinity Capture-MS Homo sapiens
160 POLR2E 5434
Affinity Capture-MS Homo sapiens
161 SETD2  
Affinity Capture-MS Homo sapiens
162 YLPM1 56252
Affinity Capture-MS Homo sapiens
163 EGFR 1956
Negative Genetic Homo sapiens
164 FUS 2521
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
165 HOXA1 3198
Two-hybrid Homo sapiens
166 MORF4L1  
Affinity Capture-MS Homo sapiens
167 EFTUD2 9343
Affinity Capture-MS Homo sapiens
168 MYC  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
169 FAM46A  
Two-hybrid Homo sapiens
170 HNRNPAB 3182
Affinity Capture-MS Homo sapiens
171 Pef1  
Two-hybrid Mus musculus
172 ARGLU1  
Affinity Capture-MS Homo sapiens
173 ADAR 103
Affinity Capture-MS Homo sapiens
174 FAM103A1  
Two-hybrid Homo sapiens
175 NKAP 79576
Affinity Capture-MS Homo sapiens
176 RNF43  
Proximity Label-MS Homo sapiens
177 RBM8A 9939
Affinity Capture-MS Homo sapiens
178 GIGYF2 26058
Affinity Capture-MS Homo sapiens
179 HNRNPH2 3188
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
180 TOE1 114034
Affinity Capture-MS Homo sapiens
181 DIDO1  
Affinity Capture-MS Homo sapiens
182 ILF3 3609
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
183 KRTAP19-6  
Two-hybrid Homo sapiens
184 SEC23B 10483
Two-hybrid Homo sapiens
185 DMRTB1  
Two-hybrid Homo sapiens
186 ESR1  
Affinity Capture-MS Homo sapiens
187 DDX39A 10212
Affinity Capture-MS Homo sapiens
188 SNRPGP15  
Affinity Capture-MS Homo sapiens
189 TNNC2  
Affinity Capture-MS Homo sapiens
190 TRIB3  
Two-hybrid Homo sapiens
191 DDX42 11325
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
192 KRAS 3845
Negative Genetic Homo sapiens
193 IFIT1 3434
Affinity Capture-MS Homo sapiens
194 CPSF6 11052
Affinity Capture-MS Homo sapiens
195 RALY 22913
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
196 FAM208A  
Affinity Capture-MS Homo sapiens
197 SLIRP 81892
Co-fractionation Homo sapiens
198 KHDRBS3  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
199 SNRPG 6637
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
200 SNRPE 6635
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
201 C19orf54  
Two-hybrid Homo sapiens
202 TGS1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
203 BOLL  
Two-hybrid Homo sapiens
204 CHEK2  
Affinity Capture-MS Homo sapiens
205 HNRNPR 10236
Affinity Capture-MS Homo sapiens
206 PPP1R10  
Affinity Capture-MS Homo sapiens
207 SRSF8 10929
Affinity Capture-MS Homo sapiens
208 HNRNPUL2 221092
Affinity Capture-MS Homo sapiens
209 CAPZB 832
Affinity Capture-MS Homo sapiens
210 VRK2 7444
Affinity Capture-MS Homo sapiens
211 KRTAP19-2  
Two-hybrid Homo sapiens
212 ZNF638 27332
Affinity Capture-MS Homo sapiens
213 EWSR1 2130
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
214 SF3A2 8175
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
215 Snrnp70 20637
Affinity Capture-MS Mus musculus
216 ATG16L1 55054
Affinity Capture-MS Homo sapiens
217 KRTAP19-5  
Two-hybrid Homo sapiens
218 THOC1 9984
Affinity Capture-MS Homo sapiens
219 PRR20C  
Two-hybrid Homo sapiens
220 GEMIN2 8487
Affinity Capture-MS Homo sapiens
221 FOXP1 27086
Protein-RNA Homo sapiens
222 NCOA1  
Affinity Capture-MS Homo sapiens
223 POLR2K  
Affinity Capture-MS Homo sapiens
224 P4HA1 5033
Affinity Capture-MS Homo sapiens
225 DAZAP2  
Two-hybrid Homo sapiens
226 CUL4B 8450
Affinity Capture-MS Homo sapiens
227 PPIL1 51645
Affinity Capture-MS Homo sapiens
228 HIST1H3E 8353
Affinity Capture-MS Homo sapiens
229 GOLGA2 2801
Two-hybrid Homo sapiens
230 KRTAP8-1