Gene description for SF3A2
Gene name splicing factor 3a, subunit 2, 66kDa
Gene symbol SF3A2
Other names/aliases PRP11
PRPF11
SAP62
SF3a66
Species Homo sapiens
 Database cross references - SF3A2
ExoCarta ExoCarta_8175
Entrez Gene 8175
HGNC 10766
MIM 600796
UniProt Q15428  
 SF3A2 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for SF3A2
Molecular Function
    poly(A) RNA binding GO:0044822 IDA
    zinc ion binding GO:0008270 IEA
    protein binding GO:0005515 IPI
Biological Process
    gene expression GO:0010467 TAS
    RNA splicing GO:0008380 TAS
    mRNA 3'-splice site recognition GO:0000389 TAS
    mRNA splicing, via spliceosome GO:0000398 TAS
    mRNA processing GO:0006397 IMP
Subcellular Localization
    catalytic step 2 spliceosome GO:0071013 IDA
    small nuclear ribonucleoprotein complex GO:0030532 TAS
    spliceosomal complex GO:0005681 IDA
    nucleoplasm GO:0005654 TAS
 Experiment description of studies that identified SF3A2 in exosomes
1
Experiment ID 211
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
cytochrome c|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
✔
CEM
EV Biophysical techniques
✔
TSG101|Alix
EV Cytosolic markers
✔
EpCAM|TFRC
EV Membrane markers
✔
Cytochrome C|GOLGA2
EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for SF3A2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SF3A3 10946
Invivo Homo sapiens
Invitro Homo sapiens
2 HTATSF1 27336
Affinity Capture-Western Homo sapiens
View the network image/svg+xml
 Pathways in which SF3A2 is involved
PathwayEvidenceSource
mRNA Splicing - Major Pathway TAS Reactome





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