Gene description for DHX15
Gene name DEAH (Asp-Glu-Ala-His) box helicase 15
Gene symbol DHX15
Other names/aliases DBP1
DDX15
HRH2
PRP43
PRPF43
PrPp43p
Species Homo sapiens
 Database cross references - DHX15
ExoCarta ExoCarta_1665
Vesiclepedia VP_1665
Entrez Gene 1665
HGNC 2738
MIM 603403
UniProt O43143  
 DHX15 identified in sEVs derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Breast cancer cells 34108659    
Chondrocytes 35931686    
Chondrocytes 35931686    
Colorectal cancer cells 34887515    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 34108659    
Embryonic kidney cells 36706192    
Embryonic kidney cells 36706192    
Endothelial cells 26027894    
Foreskin fibroblasts 34108659    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Gastric cancer cells 33991177    
Hepatocellular carcinoma cells 26054723    
Hepatocellular carcinoma cells 26054723    
Lymphoma cells 34108659    
Mammary cancer-associated fibroblasts 34108659    
Melanoma cells 25950383    
Melanoma cells 25950383    
Melanoma cells 25950383    
Melanoma cells 25950383    
Melanoma cells 25950383    
Melanoma cells 25950383    
Mesenchymal stem cells 36408942    
Monocytic leukemia cells 34108659    
Normal mammary epithelial cells 34108659    
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic cancer cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pancreatic duct epithalial cells 34108659    
Pluripotent stem cells 34108659    
Prostate cancer cells 25844599    
T lymphocytes 34108659    
Thymus 23844026    
 Gene ontology annotations for DHX15
Molecular Function
    DNA clamp loader activity GO:0003689 IEA
    RNA binding GO:0003723 HDA
    RNA binding GO:0003723 IBA
    RNA binding GO:0003723 IDA
    RNA helicase activity GO:0003724 IDA
    double-stranded RNA binding GO:0003725 IDA
    helicase activity GO:0004386 IBA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    ATP-dependent activity, acting on RNA GO:0008186 TAS
    ATP hydrolysis activity GO:0016887 IEA
    cohesin loader activity GO:0061775 IEA
    chromatin extrusion motor activity GO:0140584 IEA
    ATP-dependent H3-H4 histone complex chaperone activity GO:0140665 IEA
    ATP-dependent H2AZ histone chaperone activity GO:0140849 IEA
Biological Process
    mRNA splicing, via spliceosome GO:0000398 TAS
    chromatin remodeling GO:0006338 IEA
    mRNA processing GO:0006397 TAS
    RNA splicing GO:0008380 IC
    response to toxic substance GO:0009636 IEA
    defense response to bacterium GO:0042742 IEA
    positive regulation of canonical NF-kappaB signal transduction GO:0043123 IDA
    response to alkaloid GO:0043279 IEA
    defense response to virus GO:0051607 IDA
    antiviral innate immune response GO:0140374 IDA
    chromatin looping GO:0140588 IEA
Subcellular Localization
    nucleus GO:0005634 TAS
    nucleoplasm GO:0005654 TAS
    spliceosomal complex GO:0005681 IBA
    U12-type spliceosomal complex GO:0005689 IDA
    nucleolus GO:0005730 IEA
    nuclear speck GO:0016607 IDA
    U2-type post-mRNA release spliceosomal complex GO:0071008 IDA
 Experiment description of studies that identified DHX15 in sEVs
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 412
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MCF7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
6
Experiment ID 414
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
7
Experiment ID 426
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
8
Experiment ID 427
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Breast cancer cells
Sample name MDA-MB-231 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
9
Experiment ID 497
MISEV standards
✘ Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
10
Experiment ID 498
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
11
Experiment ID 1203
MISEV standards
✔
EM
Biophysical techniques
✔
SDCBP|FLOT1|CD9|CD81|CD63|EPCAM|GAPDH|LAMP1|TFRC|CD151|CD82|LAMP2|RAB35|TSG101|FLOT2|RAB5B|ICAM1|RAB5A
Enriched markers
✘ Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 34887515    
Organism Homo sapiens
Experiment description Supermeres are functional extracellular nanoparticles replete with disease biomarkers and therapeutic targets
Authors "Zhang Q, Jeppesen DK, Higginbotham JN, Graves-Deal R, Trinh VQ, Ramirez MA, Sohn Y, Neininger AC, Taneja N, McKinley ET, Niitsu H, Cao Z, Evans R, Glass SE, Ray KC, Fissell WH, Hill S, Rose KL, Huh WJ, Washington MK, Ayers GD, Burnette DT, Sharma S, Rome LH, Franklin JL, Lee YA, Liu Q, Coffey RJ."
Journal name Nat Cell Biol
Publication year 2021
Sample Colorectal cancer cells
Sample name DiFi
Isolation/purification methods Differential centrifugation
Filtration
Centrifugal ultrafiltration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
miRNA
Methods used in the study Western blotting
Mass spectrometry
RNA sequencing
12
Experiment ID 407
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|TSG101|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
13
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
14
Experiment ID 419
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
15
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
16
Experiment ID 420
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Embryonic kidney cells
Sample name HEK293T - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
17
Experiment ID 1275
MISEV standards
Biophysical techniques
✔
CD9|TSG101|FLOT1|FLOT2|RAB35|RAB5A|GAPDH|TFRC|CD63|Alix
Enriched markers
✔
PCNA|CANX|GAPDH|HSP90AA1|HSP90B1
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36706192    
Organism Homo sapiens
Experiment description Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles
Authors "Choi S, Yang Z, Wang Q, Qiao Z, Sun M, Wiggins J, Xiang SH, Lu Q."
Journal name Sci Adv
Publication year 2023
Sample Embryonic kidney cells
Sample name HEK293T
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
18
Experiment ID 1280
MISEV standards
Biophysical techniques
✔
TSG101|CD9|FLOT1|FLOT2|RAB35|RAB5A|GAPDH|TFRC|CD63|Alix
Enriched markers
✔
PCNA|CANX|GAPDH|HSP90AA1|HSP90B1
Negative markers
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36706192    
Organism Homo sapiens
Experiment description Displaying and delivering viral membrane antigens via WW domain-activated extracellular vesicles
Authors "Choi S, Yang Z, Wang Q, Qiao Z, Sun M, Wiggins J, Xiang SH, Lu Q."
Journal name Sci Adv
Publication year 2023
Sample Embryonic kidney cells
Sample name HEK293T - Fraction 5
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density 1.151 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
19
Experiment ID 226
MISEV standards
✔
EM
Biophysical techniques
✔
GAPDH|CD9|FLOT1
Enriched markers
✔
LMNA|H2AFX|ATP5A1|TOMM20
Negative markers
✘ Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description "Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting"
Authors "Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar"
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
20
Experiment ID 405
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Foreskin fibroblasts
Sample name BJ
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
21
Experiment ID 363
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
22
Experiment ID 364
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
23
Experiment ID 365
MISEV standards
✘ Biophysical techniques
✔
TSG101|GAPDH|AQP1|CD151|CD81|CD82|CD9|EPCAM|FLOT1|FLOT2|ICAM1|ITGA2B|LAMP2|RAB35|RAB5A|RAB5B|SDCBP|TFRC|UCHL1
Enriched markers
✔
DCLK1
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 33991177    
Organism Homo sapiens
Experiment description Cancer stem cell marker DCLK1 reprograms small extracellular vesicles toward migratory phenotype in gastric cancer cells
Authors "Carli ALE, Afshar-Sterle S, Rai A, Fang H, O'Keefe R, Tse J, Ferguson FM, Gray NS, Ernst M, Greening DW, Buchert M."
Journal name Proteomics
Publication year 2021
Sample Gastric cancer cells
Sample name MKN1 - 100K pellet
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
24
Experiment ID 234
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-C3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
25
Experiment ID 235
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
26
Experiment ID 417
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Lymphoma cells
Sample name Raji
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
27
Experiment ID 411
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Mammary cancer-associated fibroblasts
Sample name mCAF
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
28
Experiment ID 254
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1|CD81
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name MNT-1
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
29
Experiment ID 255
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name G1
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
30
Experiment ID 256
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name 501mel
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
31
Experiment ID 257
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name Daju
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
32
Experiment ID 258
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1|CD81
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name SKMEL28
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
33
Experiment ID 259
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|FLOT1
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25950383    
Organism Homo sapiens
Experiment description Proteome characterization of melanoma exosomes reveals a specific signature for metastatic cell lines
Authors "Lazar I, Clement E, Ducoux-Petit M, Denat L, Soldan V, Dauvillier S, Balor S4, Burlet-Schiltz O1, Larue L, Muller C Nieto L"
Journal name Pigment Cell Melanoma Res
Publication year 2015
Sample Melanoma cells
Sample name A375M
Isolation/purification methods Differential centrifugation
Unltracentrifugation
Sucrose density gradient
Flotation density 1.13 - 1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
34
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
35
Experiment ID 418
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
36
Experiment ID 418
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Monocytic leukemia cells
Sample name THP-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
37
Experiment ID 413
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Normal mammary epithelial cells
Sample name MCF10A
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
38
Experiment ID 211
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
cytochrome c|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
39
Experiment ID 212
MISEV standards
✔
CEM
Biophysical techniques
✔
TSG101|Alix|EpCAM|TFRC
Enriched markers
✔
Cytochrome C|GOLGA2
Negative markers
✘ Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors "Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K."
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
40
Experiment ID 406
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35|CD81
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name BxPC3
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
41
Experiment ID 415
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
42
Experiment ID 434
MISEV standards
✘ Biophysical techniques
✔
SDCBP|FLOT1|CD81|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 7-10 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Size exclusion chromatography
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
43
Experiment ID 435
MISEV standards
✘ Biophysical techniques
✔
CD81|SDCBP|FLOT1|CD9|CD151|FLOT2|TSG101|LAMP1|TFRC|RAB5A|RAB35|GAPDH|UCHL1|ICAM1
Enriched markers
✔
CANX
Negative markers
✘ Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic cancer cells
Sample name PANC-1 - Exo-rich fractions 1-6 pooled
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
OptiPrep density gradient centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
44
Experiment ID 408
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD63|CD81|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX|ACTB
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPDE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
45
Experiment ID 409
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pancreatic duct epithalial cells
Sample name HPNE
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
46
Experiment ID 416
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD9|CD63|SDCBP|LAMP1|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample Pluripotent stem cells
Sample name PSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
47
Experiment ID 275
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|RAB5A|CD9|CD82|CD63|CD81
Enriched markers
✔
AIF
Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors "Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T."
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel sensitive
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.12-1.19 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry/Flow cytometry/Western blotting
48
Experiment ID 410
MISEV standards
✔
EM
Biophysical techniques
✔
CD81|CD63|SDCBP|LAMP1|CD9|GAPDH|FLOT1|TFRC|FLOT2|TSG101|RAB35
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 34108659    
Organism Homo sapiens
Experiment description Quantitative Proteomics Identifies the Core Proteome of Exosomes with Syntenin-1 as the highest abundant protein and a Putative Universal Biomarker
Authors "Kugeratski FG, Hodge K, Lilla S, McAndrews KM, Zhou X, Hwang RF, Zanivan S, Kalluri R."
Journal name Nat Cell Biol
Publication year 2021
Sample T lymphocytes
Sample name Jurkat
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
mRNA
Methods used in the study RT-qPCR
Western blotting
Mass spectrometry
Flow cytometry
49
Experiment ID 217
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|CD81|CD9|CD63
Enriched markers
✘ Negative markers
✔
NTA
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors "Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O."
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for DHX15
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ISG15 9636
Affinity Capture-MS Homo sapiens
2 PPP1CB 5500
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
3 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
4 SRPK2 6733
Affinity Capture-MS Homo sapiens
5 DDX17 10521
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
6 ACTC1 70
Proximity Label-MS Homo sapiens
7 MAP4 4134
Co-fractionation Homo sapiens
8 KIF20A 10112
Affinity Capture-MS Homo sapiens
9 UBC 7316
Reconstituted Complex Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
10 PRPF40A 55660
Reconstituted Complex Homo sapiens
11 SOX2  
Affinity Capture-MS Homo sapiens
12 LAMC1 3915
Co-fractionation Homo sapiens
13 KIF23 9493
Affinity Capture-MS Homo sapiens
14 NDRG1 10397
Co-fractionation Homo sapiens
15 SF3B1 23451
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
16 AGGF1  
Two-hybrid Homo sapiens
17 AI837181  
Affinity Capture-MS Mus musculus
18 HSPH1 10808
Co-fractionation Homo sapiens
19 FBL 2091
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
20 TFIP11  
Affinity Capture-Western Homo sapiens
Co-fractionation Homo sapiens
21 RPF2 84154
Co-fractionation Homo sapiens
22 Nhp2l1 20826
Affinity Capture-MS Mus musculus
23 SNRPD3 6634
Co-fractionation Homo sapiens
24 HMG20B  
Co-fractionation Homo sapiens
25 GPATCH3  
Affinity Capture-MS Homo sapiens
26 POLR2C 5432
Affinity Capture-MS Homo sapiens
27 SFN 2810
Affinity Capture-MS Homo sapiens
28 SLC30A9 10463
Co-fractionation Homo sapiens
29 MECP2 4204
Affinity Capture-MS Homo sapiens
30 NSFL1C 55968
Co-fractionation Homo sapiens
31 ARIH2 10425
Affinity Capture-MS Homo sapiens
32 MSN 4478
Co-fractionation Homo sapiens
33 KIF14 9928
Affinity Capture-MS Homo sapiens
34 RBMX 27316
Co-fractionation Homo sapiens
35 UNK  
Affinity Capture-RNA Homo sapiens
36 CHMP4C 92421
Affinity Capture-MS Homo sapiens
37 WBP4  
Reconstituted Complex Homo sapiens
38 CAPZA1 829
Co-fractionation Homo sapiens
39 USP11 8237
Affinity Capture-MS Homo sapiens
40 PSMA4 5685
Co-fractionation Homo sapiens
41 SRSF3 6428
Co-fractionation Homo sapiens
42 TUFM 7284
Co-fractionation Homo sapiens
43 PABPC1 26986
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
44 CARM1 10498
Co-fractionation Homo sapiens
45 YAP1 10413
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
46 SLX4  
Affinity Capture-MS Homo sapiens
47 RPL31 6160
Co-fractionation Homo sapiens
48 ALKBH3  
Affinity Capture-MS Homo sapiens
49 SYNCRIP 10492
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
50 KIAA1143  
Co-fractionation Homo sapiens
51 ENO1 2023
Affinity Capture-RNA Homo sapiens
52 CUL2 8453
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
53 SRPK3  
Affinity Capture-MS Homo sapiens
54 DDX39B 7919
Affinity Capture-MS Homo sapiens
55 SRPK1 6732
Co-fractionation Homo sapiens
56 ANLN 54443
Affinity Capture-MS Homo sapiens
57 TMPO 7112
Affinity Capture-MS Homo sapiens
58 RBM39 9584
Affinity Capture-MS Homo sapiens
59 SUGP1  
Two-hybrid Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Co-fractionation Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Luminescence Homo sapiens
60 SIRT7  
Affinity Capture-MS Homo sapiens
61 CD2BP2 10421
Affinity Capture-MS Homo sapiens
62 UBE2Z 65264
Co-fractionation Homo sapiens
63 PRKAR1A 5573
Co-fractionation Homo sapiens
64 CUL3 8452
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
65 EBNA1BP2 10969
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
66 EPRS 2058
Co-fractionation Homo sapiens
67 DHX37  
Co-fractionation Homo sapiens
68 FN1 2335
Affinity Capture-MS Homo sapiens
69 ZYX 7791
Co-fractionation Homo sapiens
70 GPANK1  
Two-hybrid Homo sapiens
71 RPA3 6119
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
72 EIF2D 1939
Co-fractionation Homo sapiens
73 SF3B6 51639
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
74 PHF5A 84844
Co-fractionation Homo sapiens
75 HSPA1A 3303
Co-fractionation Homo sapiens
76 Cct8 12469
Affinity Capture-MS Mus musculus
77 ILK 3611
Co-fractionation Homo sapiens
78 CSDE1 7812
Co-fractionation Homo sapiens
79 PEX3 8504
Co-fractionation Homo sapiens
80 SUPT16H 11198
Co-fractionation Homo sapiens
81 COMMD1 150684
Affinity Capture-MS Homo sapiens
82 U2SURP 23350
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
83 DDX46 9879
Co-fractionation Homo sapiens
84 YBX1 4904
Co-fractionation Homo sapiens
85 GRK5 2869
Affinity Capture-MS Homo sapiens
86 FASN 2194
Co-fractionation Homo sapiens
87 WWOX 51741
Affinity Capture-MS Homo sapiens
88 DDX43 55510
Co-fractionation Homo sapiens
89 TRMT112 51504
Co-fractionation Homo sapiens
90 DYNC1H1 1778
Co-fractionation Homo sapiens
91 MCM5 4174
Affinity Capture-MS Homo sapiens
92 NCL 4691
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
93 HNRNPL 3191
Co-fractionation Homo sapiens
94 PAPSS1 9061
Co-fractionation Homo sapiens
95 ACO2 50
Affinity Capture-MS Homo sapiens
96 EP300 2033
Affinity Capture-MS Homo sapiens
97 PRPF4 9128
Co-fractionation Homo sapiens
98 SNW1 22938
Co-fractionation Homo sapiens
99 ADRM1 11047
Co-fractionation Homo sapiens
100 POLR1D 51082
Affinity Capture-MS Homo sapiens
101 SNRPA1 6627
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
102 KDF1  
Affinity Capture-MS Homo sapiens
103 HSPA6 3310
Co-fractionation Homo sapiens
104 ATG5 9474
Proximity Label-MS Homo sapiens
105 KIAA0020 9933
Co-fractionation Homo sapiens
106 RBM15B  
Co-fractionation Homo sapiens
107 TARDBP 23435
Co-fractionation Homo sapiens
108 RPA2 6118
Affinity Capture-MS Homo sapiens
109 NOP56 10528
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
110 HSP90AB1 3326
Cross-Linking-MS (XL-MS) Homo sapiens
111 CAND1 55832
Affinity Capture-MS Homo sapiens
112 SNRPF 6636
Affinity Capture-MS Homo sapiens
113 HSPA2 3306
Co-fractionation Homo sapiens
114 NOLC1 9221
Co-fractionation Homo sapiens
115 PUF60 22827
Co-fractionation Homo sapiens
116 PRC1 9055
Affinity Capture-MS Homo sapiens
117 TAF15 8148
Co-fractionation Homo sapiens
118 SRRM2 23524
Co-fractionation Homo sapiens
119 KIFAP3 22920
Affinity Capture-MS Homo sapiens
120 KHDRBS1 10657
Co-fractionation Homo sapiens
121 OBSL1 23363
Affinity Capture-MS Homo sapiens
122 GGA1 26088
Co-fractionation Homo sapiens
123 FANCD2  
Affinity Capture-MS Homo sapiens
124 VCAM1 7412
Affinity Capture-MS Homo sapiens
125 PFN2 5217
Co-fractionation Homo sapiens
126 CUL1 8454
Affinity Capture-MS Homo sapiens
127 PCNA 5111
Co-fractionation Homo sapiens
128 PES1 23481
Co-fractionation Homo sapiens
129 YWHAB 7529
Affinity Capture-MS Homo sapiens
130 VRK3 51231
Affinity Capture-MS Homo sapiens
131 PRPF8 10594
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
132 RBX1 9978
Co-fractionation Homo sapiens
133 TRA2A 29896
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
134 PSMD14 10213
Affinity Capture-MS Homo sapiens
135 ACIN1 22985
Co-fractionation Homo sapiens
136 RCC2 55920
Co-fractionation Homo sapiens
137 SNRNP200 23020
Co-fractionation Homo sapiens
138 SNRPB 6628
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
139 IWS1  
Co-fractionation Homo sapiens
140 SNRPD1 6632
Co-fractionation Homo sapiens
141 NELFE 7936
Affinity Capture-MS Homo sapiens
142 NKRF 55922
Two-hybrid Homo sapiens
143 SRSF1 6426
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
144 MAGOH 4116
Affinity Capture-MS Homo sapiens
145 IARS 3376
Co-fractionation Homo sapiens
146 CYLD  
Affinity Capture-MS Homo sapiens
147 SNRPB2 6629
Co-fractionation Homo sapiens
148 UFD1L 7353
Co-fractionation Homo sapiens
149 ACLY 47
Co-fractionation Homo sapiens
150 DHX36 170506
Co-fractionation Homo sapiens
151 RC3H2  
Affinity Capture-MS Homo sapiens
152 RSU1 6251
Co-fractionation Homo sapiens
153 SRSF5 6430
Co-fractionation Homo sapiens
154 FUS 2521
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
155 LARS 51520
Co-fractionation Homo sapiens
156 CDK2 1017
Affinity Capture-MS Homo sapiens
157 CEP250 11190
Affinity Capture-MS Homo sapiens
158 TADA2A  
Affinity Capture-MS Homo sapiens
159 PPP2R1A 5518
Co-fractionation Homo sapiens
160 BAG1 573
Affinity Capture-MS Homo sapiens
161 TMOD3 29766
Co-fractionation Homo sapiens
162 TCEB2 6923
Co-fractionation Homo sapiens
163 CUL7 9820
Affinity Capture-MS Homo sapiens
164 DDRGK1 65992
Affinity Capture-MS Homo sapiens
165 HUWE1 10075
Affinity Capture-MS Homo sapiens
166 NKAP 79576
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
167 AIMP1 9255
Co-fractionation Homo sapiens
168 KRT18 3875
Co-fractionation Homo sapiens
169 SPOP  
Two-hybrid Homo sapiens
170 ILF3 3609
Co-fractionation Homo sapiens
171 TP53 7157
Affinity Capture-MS Homo sapiens
172 FXR1 8087
Two-hybrid Homo sapiens
173 SF3B4 10262
Co-fractionation Homo sapiens
174 KNOP1 400506
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
175 LSS 4047
Affinity Capture-MS Homo sapiens
176 OTUB1 55611
Co-fractionation Homo sapiens
177 HNRNPK 3190
Co-fractionation Homo sapiens
178 MMGT1 93380
Co-fractionation Homo sapiens
179 ESR1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
180 BAG5 9529
Affinity Capture-MS Homo sapiens
181 DDX42 11325
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
182 TOPORS  
Affinity Capture-MS Homo sapiens
183 KRAS 3845
Negative Genetic Homo sapiens
184 MYC  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
185 PRMT1 3276
Affinity Capture-MS Homo sapiens
186 RANBP2 5903
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
187 RALY 22913
Co-fractionation Homo sapiens
188 GCFC2  
Co-fractionation Homo sapiens
189 HNRNPH1 3187
Co-fractionation Homo sapiens
190 SENP3 26168
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
191 NOP58 51602
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
192 DNAJC9 23234
Co-fractionation Homo sapiens
193 TCEB1 6921
Co-fractionation Homo sapiens
194 SNRPE 6635
Co-fractionation Homo sapiens
195 DNAJC8 22826
Co-fractionation Homo sapiens
196 Prpf8 192159
Affinity Capture-MS Mus musculus
197 HNRNPR 10236
Co-fractionation Homo sapiens
198 PSMD10 5716
Co-fractionation Homo sapiens
199 PTPN1 5770
Co-fractionation Homo sapiens
200 APBB1  
Reconstituted Complex Homo sapiens
201 SF3B5 83443
Co-fractionation Homo sapiens
202 CUL4B 8450
Affinity Capture-MS Homo sapiens
203 CAPZB 832
Co-fractionation Homo sapiens
204 MCM2 4171
Affinity Capture-MS Homo sapiens
205 IQGAP1 8826
Affinity Capture-MS Homo sapiens
206 MCTS1 28985
Co-fractionation Homo sapiens
207 EWSR1 2130
Co-fractionation Homo sapiens
208 SF3A2 8175
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
209 ITGA4 3676
Affinity Capture-MS Homo sapiens
210 DDX18 8886
Co-fractionation Homo sapiens
211 PABPC4 8761
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
212 USP37  
Proximity Label-MS Homo sapiens
213 HSPA8 3312
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
214 PSME3 10197
Affinity Capture-MS Homo sapiens
215 VTN 7448
Co-fractionation Homo sapiens
216 EPB41L3 23136
Affinity Capture-MS Homo sapiens
217 NF2 4771
Affinity Capture-MS Homo sapiens
218 S100A2 6273
Co-fractionation Homo sapiens
219 FOXC1  
Affinity Capture-MS Homo sapiens
220 PINX1  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
221 TAF10 6881
Affinity Capture-MS Homo sapiens
222 PARK2  
Affinity Capture-MS Homo sapiens
223 MARS 4141
Co-fractionation Homo sapiens
224 DEK 7913
Co-fractionation Homo sapiens
225 CHMP4B 128866
Affinity Capture-MS Homo sapiens
226 BTF3 689
Affinity Capture-MS Homo sapiens
227 RAN 5901
Co-fractionation Homo sapiens
228 RRM1 6240
Co-fractionation Homo sapiens
229 NTRK1 4914
Affinity Capture-MS Homo sapiens
230 U2AF2 11338
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
231 RPL36 25873
Co-fractionation Homo sapiens
232 FLNB 2317
Co-fractionation Homo sapiens
233 HNRNPA3 220988
Co-fractionation Homo sapiens
234 HDAC5 10014
Affinity Capture-MS Homo sapiens
235 SF3A3 10946
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
236 RNU12 267010
Affinity Capture-MS Homo sapiens
237 LARP1 23367
Co-fractionation Homo sapiens
238 HNRNPDL 9987
Co-fractionation Homo sapiens
239 SF3B2 10992
Co-fractionation Homo sapiens
240 AHCY 191
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
241 MSH2 4436
Co-fractionation Homo sapiens
242 ECT2 1894
Affinity Capture-MS Homo sapiens
243 RNU11 26824
Affinity Capture-MS Homo sapiens
244 PSMA2 5683
Co-fractionation Homo sapiens
245 HNRNPA1 3178
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
246 HNRNPUL1 11100
Co-fractionation Homo sapiens
247 PUS7 54517
Co-fractionation Homo sapiens
248 NRBP1 29959
Co-fractionation Homo sapiens
249 PRPF19 27339
Co-fractionation Homo sapiens
250 MCMBP 79892
Co-fractionation Homo sapiens
251 RPL12 6136
Co-fractionation Homo sapiens
252 RPL22 6146
Co-fractionation Homo sapiens
253 SKIV2L2 23517
Co-fractionation Homo sapiens
254 TXNDC5 81567
Co-fractionation Homo sapiens
255 HSPD1 3329
Co-fractionation Homo sapiens
256 HSPA9 3313
Co-fractionation Homo sapiens
257 PREP 5550
Co-fractionation Homo sapiens
258 RBM17 84991
Two-hybrid Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Co-fractionation Homo sapiens
259 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
260 TTC27 55622
Co-fractionation Homo sapiens
261 PIN1 5300
Reconstituted Complex Homo sapiens
262 RPA1 6117
Affinity Capture-MS Homo sapiens
263 SNRPA 6626
Affinity Capture-MS Homo sapiens
264 HNRNPM 4670
Co-fractionation Homo sapiens
265 HSPB1 3315
Co-fractionation Homo sapiens
266 RBM15 64783
Co-fractionation Homo sapiens
267 S100A9 6280
Co-fractionation Homo sapiens
268 DDX58 23586
Affinity Capture-RNA Homo sapiens
269 TRAP1 10131
Co-fractionation Homo sapiens
270 UFL1 23376
Affinity Capture-MS Homo sapiens
271 API5 8539
Affinity Capture-MS Homo sapiens
272 HNRNPF 3185
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
273 SLBP  
Affinity Capture-Western Homo sapiens
274 AR 367
Affinity Capture-MS Homo sapiens
275 RC3H1 149041
Affinity Capture-MS Homo sapiens
276 PSMA5 5686
Affinity Capture-MS Homo sapiens
277 NEMF 9147
Co-fractionation Homo sapiens
278 NOTCH1 4851
Affinity Capture-MS Homo sapiens
279 RBM10  
Two-hybrid Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Luminescence Homo sapiens
280 UBE2H 7328
Affinity Capture-MS Homo sapiens
281 SLFN11 91607
Affinity Capture-MS Homo sapiens
282 RIT1 6016
Negative Genetic Homo sapiens
283 QARS 5859
Co-fractionation Homo sapiens
284 PSMD6 9861
Co-fractionation Homo sapiens
285 PPIE 10450
Affinity Capture-MS Homo sapiens
286 PSMD11 5717
Co-fractionation Homo sapiens
287 USP3 9960
Co-fractionation Homo sapiens
288 TDRD3  
Co-fractionation Homo sapiens
289 KARS 3735
Co-fractionation Homo sapiens
290 SNRPD2 6633
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
291 WDR36 134430
Co-fractionation Homo sapiens
292 HSPA5 3309
Co-fractionation Homo sapiens
293 ILF2 3608
Co-fractionation Homo sapiens
294 GSK3A 2931
Affinity Capture-MS Homo sapiens
295 KIAA1429 25962
Affinity Capture-MS Homo sapiens
296 Snw1  
Affinity Capture-MS Mus musculus
297 EIF4A3 9775
Affinity Capture-MS Homo sapiens
298 KIF5B 3799
Co-fractionation Homo sapiens
299 COPS5 10987
Affinity Capture-MS Homo sapiens
300 IMPDH2 3615
Co-fractionation Homo sapiens
301 ZGPAT  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
302 YWHAG 7532
Affinity Capture-MS Homo sapiens
303 PCDHA2  
Co-fractionation Homo sapiens
304 EED  
Affinity Capture-MS Homo sapiens
305 NUDCD1 84955
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
306 CEP57  
Affinity Capture-MS Homo sapiens
307 MYCN  
Affinity Capture-MS Homo sapiens
308 COMMD4 54939
Affinity Capture-MS Homo sapiens
309 CHERP 10523
Co-fractionation Homo sapiens
310 GARS 2617
Co-fractionation Homo sapiens
311 GEMIN5 25929
Co-fractionation Homo sapiens
312 FUT8 2530
Co-fractionation Homo sapiens
313 PSMC1 5700
Co-fractionation Homo sapiens
314 STAU1 6780
Affinity Capture-MS Homo sapiens
315 CCT5 22948
Co-fractionation Homo sapiens
316 NOC2L 26155
Co-fractionation Homo sapiens
317 VCP 7415
Affinity Capture-MS Homo sapiens
318 DDX5 1655
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
319 IFI16 3428
Affinity Capture-MS Homo sapiens
320 KRT75 9119
Two-hybrid Homo sapiens
321 MOV10 4343
Affinity Capture-RNA Homo sapiens
322 FH 2271
Co-fractionation Homo sapiens
323 CRY2  
Affinity Capture-MS Homo sapiens
324 DDX1 1653
Co-fractionation Homo sapiens
325 CEBPA  
Protein-peptide Homo sapiens
326 MAT2A 4144
Co-fractionation Homo sapiens
327 SRSF11 9295
Co-fractionation Homo sapiens
328 RBM5  
Two-hybrid Homo sapiens
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
329 IPO5 3843
Co-fractionation Homo sapiens
330 NR4A1  
Affinity Capture-MS Homo sapiens
331 TRIM31  
Affinity Capture-MS Homo sapiens
332 PSMD13 5719
Co-fractionation Homo sapiens
333 CCT6A 908
Co-fractionation Homo sapiens
334 RLIM 51132
Affinity Capture-MS Homo sapiens
335 GTF3C1  
Co-fractionation Homo sapiens
336 XAB2 56949
Co-fractionation Homo sapiens
337 NXF1 10482
Affinity Capture-RNA Homo sapiens
Co-fractionation Homo sapiens
338 SF3A1 10291
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
339 AURKB 9212
Affinity Capture-MS Homo sapiens
340 DKC1 1736
Co-fractionation Homo sapiens
341 FBXO6 26270
Affinity Capture-MS Homo sapiens
342 SEC31A 22872
Co-fractionation Homo sapiens
343 INO80B 83444
Affinity Capture-MS Homo sapiens
344 NFKB1 4790
Co-fractionation Homo sapiens
345 SRSF10 10772
Co-fractionation Homo sapiens
346 SF3B3 23450
Co-fractionation Homo sapiens
Co-fractionation Homo sapiens
347 RARS 5917
Co-fractionation Homo sapiens
348 NOL6 65083
Co-fractionation Homo sapiens
349 C9orf72  
Affinity Capture-MS Homo sapiens
350 TXLNA 200081
Co-fractionation Homo sapiens
351 LBR 3930
Co-fractionation Homo sapiens
352 ARRB2 409
Affinity Capture-MS Homo sapiens
353 SRRM1 10250
Co-fractionation Homo sapiens
354 ZNF746  
Affinity Capture-MS Homo sapiens
355 CUL5 8065
Affinity Capture-MS Homo sapiens
356 SMNDC1  
Co-fractionation Homo sapiens
357 ATXN2 6311
Co-fractionation Homo sapiens
358 Sf3a1 67465
Affinity Capture-MS Mus musculus
359 HDGF 3068
Affinity Capture-MS Homo sapiens
360 RNF7  
Co-fractionation Homo sapiens
361 GSTM3 2947
Co-fractionation Homo sapiens
362 TMEM126B 55863
Co-fractionation Homo sapiens
363 TRIP4 9325
Affinity Capture-MS Homo sapiens
364 SRSF7 6432
Co-fractionation Homo sapiens
365 PINK1  
Affinity Capture-MS Homo sapiens
366 CUL4A 8451
Affinity Capture-MS Homo sapiens
367 NDUFAF4 29078
Co-fractionation Homo sapiens
368 HNRNPU 3192
Co-fractionation Homo sapiens
369 CDC5L 988
Co-fractionation Homo sapiens
370 DDX3X 1654
Co-fractionation Homo sapiens
371 ECSIT 51295
Co-fractionation Homo sapiens
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Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here