Gene description for TAF10
Gene name TAF10 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 30kDa
Gene symbol TAF10
Other names/aliases TAF2A
TAF2H
TAFII30
Species Homo sapiens
 Database cross references - TAF10
ExoCarta ExoCarta_6881
Entrez Gene 6881
HGNC 11543
MIM 600475
UniProt Q12962  
 TAF10 identified in exosomes derived from the following tissue/cell type
Neuroblastoma cells 25944692    
 Gene ontology annotations for TAF10
Molecular Function
    transcription coactivator activity GO:0003713 IDA
    protein binding GO:0005515 IPI
    estrogen receptor binding GO:0030331 IDA
    sequence-specific DNA binding transcription factor activity GO:0003700 IDA
    histone acetyltransferase activity GO:0004402 IDA
    enzyme binding GO:0019899 IPI
    RNA polymerase binding GO:0070063 IDA
Biological Process
    transcription initiation from RNA polymerase II promoter GO:0006367 TAS
    chromatin organization GO:0006325 TAS
    transcription from RNA polymerase II promoter GO:0006366 TAS
    transcription elongation from RNA polymerase II promoter GO:0006368 TAS
    regulation of transcription, DNA-templated GO:0006355 IEA
    histone deubiquitination GO:0016578 IDA
    protein homooligomerization GO:0051260 IDA
    gene expression GO:0010467 TAS
    histone H3 acetylation GO:0043966 IDA
    DNA-templated transcription, initiation GO:0006352 IDA
    viral process GO:0016032 TAS
Subcellular Localization
    perinuclear region of cytoplasm GO:0048471 IDA
    nucleus GO:0005634 IDA
    transcription factor TFIID complex GO:0005669 IDA
    nucleoplasm GO:0005654 TAS
    cytoplasm GO:0005737 IDA
    STAGA complex GO:0030914 IDA
    transcription factor TFTC complex GO:0033276 IDA
    PCAF complex GO:0000125 IDA
 Experiment description of studies that identified TAF10 in exosomes
1
Experiment ID 224
ISEV standards
EM|AFM
EV Biophysical techniques
Alix|TSG101
EV Cytosolic markers
CD63|CD81
EV Membrane markers
GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25944692    
Organism Homo sapiens
Experiment description Proteogenomic analysis reveals exosomes are more oncogenic than ectosomes
Authors Keerthikumar S, Gangoda L, Liem M, Fonseka P, Atukorala I, Ozcitti C, Mechler A, Adda CG, Ang CS, Mathivanan S
Journal name Oncotarget
Publication year 2015
Sample Neuroblastoma cells
Sample name SH-SY5Y
Isolation/purification methods Differential centrifugation
Ultracentrifugation
OptiPrep density gradient
Flotation density 1.10 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Western blotting
 Protein-protein interactions for TAF10
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SUPT3H  
Affinity Capture-Western Homo sapiens
2 FTL 2512
Two-hybrid Homo sapiens
3 TBP  
Co-purification Homo sapiens
4 FANCA  
Two-hybrid Homo sapiens
5 MYC  
Co-purification Homo sapiens
6 TAF4 6874
Affinity Capture-Western Homo sapiens
7 CECR2  
Two-hybrid Homo sapiens
8 TAF13  
Invitro Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml



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