Gene description for PRPF31
Gene name pre-mRNA processing factor 31
Gene symbol PRPF31
Other names/aliases NY-BR-99
PRP31
RP11
SNRNP61
Species Homo sapiens
 Database cross references - PRPF31
ExoCarta ExoCarta_26121
Entrez Gene 26121
HGNC 15446
MIM 606419
UniProt Q8WWY3  
 PRPF31 identified in exosomes derived from the following tissue/cell type
Ovarian cancer cells 23333927    
Ovarian cancer cells 23333927    
 Gene ontology annotations for PRPF31
Molecular Function
    protein binding GO:0005515 IPI
    snRNP binding GO:0070990 IPI
    poly(A) RNA binding GO:0044822 IDA
    ribonucleoprotein complex binding GO:0043021 IDA
Biological Process
    spliceosomal tri-snRNP complex assembly GO:0000244 IMP
    mRNA splicing, via spliceosome GO:0000398 IDA
Subcellular Localization
    nuclear speck GO:0016607 IDA
    nucleus GO:0005634 IDA
    Cajal body GO:0015030 IDA
    U2-type spliceosomal complex GO:0005684 IC
    U4/U6 x U5 tri-snRNP complex GO:0046540 IDA
    MLL1 complex GO:0071339 IDA
    U4 snRNP GO:0005687 IDA
    U4atac snRNP GO:0005690 TAS
 Experiment description of studies that identified PRPF31 in exosomes
1
Experiment ID 211
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
cytochrome c|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name IGROV1
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 212
ISEV standards
CEM
EV Biophysical techniques
TSG101|Alix
EV Cytosolic markers
EpCAM|TFRC
EV Membrane markers
Cytochrome C|GOLGA2
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23333927    
Organism Homo sapiens
Experiment description Characterization and proteomic analysis of ovarian cancer-derived exosomes.
Authors Liang B, Peng P, Chen S, Li L, Zhang M, Cao D, Yang J, Li H, Gui T, Li X, Shen K.
Journal name J Proteomics
Publication year 2013
Sample Ovarian cancer cells
Sample name OVCAR-3
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Sucrose density gradient
Flotation density 1.09-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for PRPF31
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 FANCA  
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which PRPF31 is involved
No pathways found





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