Gene description for HES7
Gene name hes family bHLH transcription factor 7
Gene symbol HES7
Other names/aliases SCDO4
bHLHb37
Species Homo sapiens
 Database cross references - HES7
ExoCarta ExoCarta_84667
Entrez Gene 84667
HGNC 15977
MIM 608059
UniProt Q9BYE0  
 HES7 identified in exosomes derived from the following tissue/cell type
Endothelial cells 26027894    
 Gene ontology annotations for HES7
Molecular Function
    DNA binding GO:0003677 NAS
    protein dimerization activity GO:0046983 IEA
    transcription factor binding GO:0008134 NAS
Biological Process
    post-anal tail morphogenesis GO:0036342 IEA
    transcription, DNA-templated GO:0006351 IEA
    mesoderm development GO:0007498 NAS
    Notch signaling pathway GO:0007219 IEA
    regulation of somitogenesis GO:0014807 IEA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 IEA
    skeletal system development GO:0001501 IEA
    rhythmic process GO:0048511 IEA
    somitogenesis GO:0001756 IEA
Subcellular Localization
    nucleus GO:0005634 NAS
 Experiment description of studies that identified HES7 in exosomes
1
Experiment ID 226
ISEV standards
EM
EV Biophysical techniques
GAPDH
EV Cytosolic markers
CD9|FLOT1
EV Membrane markers
LMNA|H2AFX|ATP5A1|TOMM20
EV Negative markers
EV Particle analysis
Identified molecule mRNA
Identification method Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
PubMed ID 26027894    
Organism Homo sapiens
Experiment description Quantitative and qualitative analysis of small RNAs in human endothelial cells and exosomes provides insights into localized RNA processing, degradation and sorting
Authors Bas W. M. van Balkom, Almut S. Eisele, D. Michiel Pegtel, Sander Bervoets, Marianne C. Verhaar
Journal name Journal of Extracellular Vesicles
Publication year 2015
Sample Endothelial cells
Sample name HMEC-1
Isolation/purification methods Differential ultracentrifugation
Sucrose density gradient
Flotation density 1.10 g/mL
Molecules identified in the study miRNA
Protein
snoRNA
lncRNA
yRNA
snRNA
mRNA
ncRNA
mtRNA
vtRNA
scaRNA
lincRNA
Methods used in the study Small RNA sequencing (Illumina HiSeq 2000 (Solexa)
Western blotting
 Protein-protein interactions for HES7
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which HES7 is involved
No pathways found





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