Gene description for LSM6
Gene name LSM6 homolog, U6 small nuclear RNA associated (S. cerevisiae)
Gene symbol LSM6
Other names/aliases YDR378C
Species Homo sapiens
 Database cross references - LSM6
ExoCarta ExoCarta_11157
Vesiclepedia VP_11157
Entrez Gene 11157
HGNC 17017
MIM 607286
UniProt P62312  
 LSM6 identified in exosomes derived from the following tissue/cell type
Mesenchymal stem cells 36408942    
Thymus 23844026    
 Gene ontology annotations for LSM6
Molecular Function
    protein binding GO:0005515 IPI
    poly(A) RNA binding GO:0044822 IDA
Biological Process
    nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay GO:0000288 TAS
    gene expression GO:0010467 TAS
    tRNA processing GO:0008033 IEA
    mRNA splicing, via spliceosome GO:0000398 IBA
    RNA splicing GO:0008380 TAS
    exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay GO:0043928 TAS
    maturation of SSU-rRNA GO:0030490 IBA
Subcellular Localization
    small nuclear ribonucleoprotein complex GO:0030532 TAS
    spliceosomal complex GO:0005681 IEA
    extracellular exosome GO:0070062 IDA
    cytoplasmic mRNA processing body GO:0000932 IBA
    U4/U6 x U5 tri-snRNP complex GO:0046540 IBA
    nucleolus GO:0005730 IBA
    small nucleolar ribonucleoprotein complex GO:0005732 IBA
    U6 snRNP GO:0005688 IBA
    cytosol GO:0005829 TAS
 Experiment description of studies that identified LSM6 in exosomes
1
Experiment ID 488
MISEV standards
✔
EM
EV Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
EV Enriched markers
✔
CANX
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 217
MISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|CD81|CD9|CD63
EV Enriched markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for LSM6
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 LSM5 23658
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
2 MCRS1  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
3 LSM2  
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
4 LSM7  
Invitro Homo sapiens
5 LSM8 51691
Invitro Homo sapiens
6 LSM4 25804
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
7 SMN1 6606
Affinity Capture-MS Homo sapiens
Invitro Homo sapiens
8 LSM3 27258
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
9 LSM1 27257
Invitro Homo sapiens
Affinity Capture-MS Homo sapiens
10 POLD2 5425
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
11 SNRPD2 6633
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which LSM6 is involved
PathwayEvidenceSource
mRNA decay by 5' to 3' exoribonuclease TAS Reactome





Perform bioinformatics analysis of your extracellular vesicle data set using FunRich, a open access standalone tool. NEW UPDATED VERSION OF FunRich available for download (12/09/2016) from here