Gene description for GEMIN2
Gene name gem (nuclear organelle) associated protein 2
Gene symbol GEMIN2
Other names/aliases SIP1
SIP1-delta
Species Homo sapiens
 Database cross references - GEMIN2
ExoCarta ExoCarta_8487
Vesiclepedia VP_8487
Entrez Gene 8487
HGNC 10884
MIM 602595
UniProt O14893  
 GEMIN2 identified in exosomes derived from the following tissue/cell type
Thymus 23844026    
 Gene ontology annotations for GEMIN2
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    RNA splicing GO:0008380 TAS
    gene expression GO:0010467 TAS
    spliceosomal complex assembly GO:0000245 IEA
    ncRNA metabolic process GO:0034660 TAS
    mRNA processing GO:0006397 TAS
    RNA splicing, via transesterification reactions GO:0000375 TAS
    spliceosomal snRNP assembly GO:0000387 TAS
Subcellular Localization
    cytosol GO:0005829 TAS
    SMN-Sm protein complex GO:0034719 IDA
    Gemini of coiled bodies GO:0097504 IEA
    SMN complex GO:0032797 IDA
    nucleolus GO:0005730 IDA
    spliceosomal complex GO:0005681 IEA
    cytoplasm GO:0005737 IDA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 TAS
 Experiment description of studies that identified GEMIN2 in exosomes
1
Experiment ID 217
MISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|CD81|CD9|CD63
EV Enriched markers
✘ EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23844026    
Organism Homo sapiens
Experiment description Characterization of human thymic exosomes.
Authors Skogberg G, Gudmundsdottir J, van der Post S, Sandstrom K, Bruhn S, Benson M, Mincheva-Nilsson L, Baranov V, Telemo E, Ekwall O.
Journal name PLoS One
Publication year 2013
Sample Thymus
Sample name Normal-Thymus
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
 Protein-protein interactions for GEMIN2
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 SRSF4 6429
Two-hybrid Homo sapiens
2 GEMIN6  
Affinity Capture-Western Homo sapiens
3 GEMIN5 25929
Affinity Capture-Western Homo sapiens
4 SRSF1 6426
Two-hybrid Homo sapiens
5 FBL 2091
Affinity Capture-Western Homo sapiens
6 DDX20 11218
Invivo Homo sapiens
Invitro Homo sapiens
7 SNRNP70 6625
Invitro Homo sapiens
Two-hybrid Homo sapiens
8 RNPS1 10921
Affinity Capture-MS Homo sapiens
9 SMN1 6606
Affinity Capture-Western Homo sapiens
Co-purification Homo sapiens
Co-fractionation Homo sapiens
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
10 GAR1 54433
Affinity Capture-Western Homo sapiens
11 CTBP1 1487
Affinity Capture-Western Homo sapiens
12 SRSF2 6427
Invitro Homo sapiens
Two-hybrid Homo sapiens
13 LGALS1 3956
Affinity Capture-Western Homo sapiens
14 U2AF2 11338
Invivo Homo sapiens
Invitro Homo sapiens
Two-hybrid Homo sapiens
15 SRSF3 6428
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which GEMIN2 is involved
PathwayEvidenceSource
snRNP Assembly TAS Reactome





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