Gene description for Snrnp70
Gene name small nuclear ribonucleoprotein 70 (U1)
Gene symbol Snrnp70
Other names/aliases 2700022N21Rik
3200002N22Rik
AI325098
R74807
Rnu1p70
Rnulp70
Snrp70
Srnp70
U1-70
U1-70K
Species Mus musculus
 Database cross references - Snrnp70
ExoCarta ExoCarta_20637
Entrez Gene 20637
UniProt Q62376  
 Snrnp70 identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Snrnp70
Molecular Function
    nucleic acid binding GO:0003676 IEA
    nucleotide binding GO:0000166 IEA
    poly(A) RNA binding GO:0044822 ISO
    RNA binding GO:0003723 ISO
Biological Process
    positive regulation of mRNA splicing, via spliceosome GO:0048026 IMP
    regulation of RNA splicing GO:0043484 ISO
    mRNA splicing, via spliceosome GO:0000398 ISO
Subcellular Localization
    nucleus GO:0005634 ISS
    U1 snRNP GO:0005685 ISO
    spliceosomal complex GO:0005681 ISO
    nucleoplasm GO:0005654 ISO
    ribonucleoprotein complex GO:0030529 IEA
 Experiment description of studies that identified Snrnp70 in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Snrnp70
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Snrnp70 is involved
PathwayEvidenceSource
mRNA Splicing - Major Pathway IEA Reactome





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