Gene description for PKN3
Gene name protein kinase N3
Gene symbol PKN3
Other names/aliases UTDP4-1
Species Homo sapiens
 Database cross references - PKN3
ExoCarta ExoCarta_29941
Entrez Gene 29941
HGNC 17999
MIM 610714
UniProt Q6P5Z2  
 PKN3 identified in exosomes derived from the following tissue/cell type
Prostate cancer cells 25844599    
 Gene ontology annotations for PKN3
Molecular Function
    ATP binding GO:0005524 IEA
    protein binding GO:0005515 IPI
    protein kinase C activity GO:0004697 IEA
    protein kinase activity GO:0004672 TAS
Biological Process
    protein phosphorylation GO:0006468 IEA
    epithelial cell migration GO:0010631 IDA
    signal transduction GO:0007165 IEA
Subcellular Localization
    perinuclear region of cytoplasm GO:0048471 IEA
    nucleus GO:0005634 IEA
    Golgi apparatus GO:0005794 TAS
 Experiment description of studies that identified PKN3 in exosomes
1
Experiment ID 274
ISEV standards
✔
EM
EV Biophysical techniques
✔
TSG101|Alix|RAB5A
EV Cytosolic markers
✔
CD9|CD82|CD63|CD81
EV Membrane markers
✔
AIF
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 25844599    
Organism Homo sapiens
Experiment description Molecular profiling of prostate cancer derived exosomes may reveal a predictive signature for response to docetaxel.
Authors Kharaziha P, Chioureas D, Rutishauser D, Baltatzis G, Lennartsson L, Fonseca P, Azimi A, Hultenby K, Zubarev R, Ullen A, Yachnin J, Nilsson S, Panaretakis T.
Journal name Oncotarget
Publication year 2015
Sample Prostate cancer cells
Sample name DU145 - Docetaxel resistant
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.18 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
Flow cytometry
Western blotting
 Protein-protein interactions for PKN3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ARHGAP26 23092
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
2 ARHGAP10  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
View the network image/svg+xml
 Pathways in which PKN3 is involved
PathwayEvidenceSource
RHO GTPases activate PKNs TAS Reactome





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