Gene description for Set
Gene name SET nuclear oncogene
Gene symbol Set
Other names/aliases 2610030F17Rik
5730420M11Rik
AA407739
I-2PP2A
StF-IT-1
TAF-I
Species Mus musculus
 Database cross references - Set
ExoCarta ExoCarta_56086
Entrez Gene 56086
UniProt Q9EQU5  
 Set identified in exosomes derived from the following tissue/cell type
Mast cells 17486113    
 Gene ontology annotations for Set
Molecular Function
    DNA binding GO:0003677 IEA
Biological Process
    negative regulation of neuron apoptotic process GO:0043524 ISO
    negative regulation of transcription, DNA-templated GO:0045892 ISO
    nucleosome assembly GO:0006334 IEA
Subcellular Localization
    endoplasmic reticulum GO:0005783 ISO
    perinuclear region of cytoplasm GO:0048471 ISO
    protein complex GO:0043234 ISO
    cytoplasm GO:0005737 ISO
    nucleus GO:0005634 ISO
 Experiment description of studies that identified Set in exosomes
1
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule mrna
Identification method Microarray
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Set
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Set is involved
PathwayEvidenceSource
Condensation of Prophase Chromosomes IEA Reactome
HuR stabilizes mRNA IEA Reactome





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