Gene description for Alb
Gene name albumin
Gene symbol Alb
Other names/aliases Alb-1
Alb1
Species Mus musculus
 Database cross references - Alb
ExoCarta ExoCarta_11657
Entrez Gene 11657
UniProt P07724  
 Alb identified in exosomes derived from the following tissue/cell type
Brain cancer cells 19109410    
Fibroblasts 23260141    
Mast cells 17486113    
Mov neuroglial cells 15210972    
 Gene ontology annotations for Alb
Molecular Function
    toxic substance binding GO:0015643 ISO
    lipid binding GO:0008289 IEA
    fatty acid binding GO:0005504 ISO
    chaperone binding GO:0051087 ISO
    pyridoxal phosphate binding GO:0030170 ISO
    drug binding GO:0008144 ISO
    zinc ion binding GO:0008270 ISO
    metal ion binding GO:0046872 IEA
    DNA binding GO:0003677 ISO
    oxygen binding GO:0019825 ISO
    enzyme binding GO:0019899 ISO
Biological Process
    positive regulation of circadian sleep/wake cycle, non-REM sleep GO:0046010 ISO
    negative regulation of apoptotic process GO:0043066 ISO
    transport GO:0006810 IEA
    maintenance of mitochondrion location GO:0051659 ISO
    hemolysis by symbiont of host erythrocytes GO:0019836 ISO
    cellular response to starvation GO:0009267 ISO
Subcellular Localization
    extracellular region GO:0005576 IDA
    basement membrane GO:0005604 ISO
    cytoplasm GO:0005737 IDA
    nucleus GO:0005634 ISO
    protein complex GO:0043234 ISO
    extracellular exosome GO:0070062 ISO
    blood microparticle GO:0072562 ISO
    myelin sheath GO:0043209 IDA
    extracellular space GO:0005615 ISO
 Experiment description of studies that identified Alb in exosomes
1
Experiment ID 26
ISEV standards
✔
EM
EV Biophysical techniques
✔
Alix|GAPDH|HSP70
EV Cytosolic markers
✔
CD9
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19109410    
Organism Mus musculus
Experiment description Proteomic and immunologic analyses of brain tumor exosomes.
Authors Graner MW, Alzate O, Dechkovskaia AM, Keene JD, Sampson JH, Mitchell DA, Bigner DD
Journal name FASEB
Publication year 2008
Sample Brain cancer cells
Sample name SMA560vIII
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.13-1.15 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [MALDI TOF/TOF]
Western blotting
2
Experiment ID 210
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD81|FLOT1
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
3
Experiment ID 15
ISEV standards
✔
EM
EV Biophysical techniques
✘ EV Cytosolic markers
✔
CD63
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
4
Experiment ID 39
ISEV standards
✔
IEM
EV Biophysical techniques
✔
TSG101|HSC70
EV Cytosolic markers
✔
FLOT1
EV Membrane markers
✘ EV Negative markers
✘ EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 15210972    
Organism Mus musculus
Experiment description Cells release prions in association with exosomes.
Authors Fevrier B, Vilette D, Archer F, Loew D, Faigle W, Vidal M, Laude H, Raposo G
Journal name PNAS
Publication year 2004
Sample Mov neuroglial cells
Sample name Mov neuroglial cell
Isolation/purification methods Differential centrifugation
Sucrose density gradient
Flotation density 1.14 g/mL
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [QSTAR]
Western blotting
Immunoelectron Microscopy
 Protein-protein interactions for Alb
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.



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