Gene description for ZMYND11
Gene name zinc finger, MYND-type containing 11
Gene symbol ZMYND11
Other names/aliases BRAM1
BS69
MRD30
Species Homo sapiens
 Database cross references - ZMYND11
ExoCarta ExoCarta_10771
Entrez Gene 10771
HGNC 16966
MIM 608668
UniProt Q15326  
 ZMYND11 identified in exosomes derived from the following tissue/cell type
Hepatocellular carcinoma cells 26054723    
 Gene ontology annotations for ZMYND11
Molecular Function
    methylated histone binding GO:0035064 ISS
    transcription corepressor activity GO:0003714 ISS
    protein binding GO:0005515 IPI
    zinc ion binding GO:0008270 ISS
    DNA binding GO:0003677 IEA
Biological Process
    viral process GO:0016032 IEA
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 TAS
    transcription, DNA-templated GO:0006351 IEA
    cell proliferation GO:0008283 TAS
    negative regulation of I-kappaB kinase/NF-kappaB signaling GO:0043124 IMP
    negative regulation of extrinsic apoptotic signaling pathway GO:2001237 IMP
    negative regulation of JNK cascade GO:0046329 IMP
    regulation of transcription elongation from RNA polymerase II promoter GO:0034243 ISS
    chromatin modification GO:0016568 IEA
    cell cycle GO:0007049 IEA
Subcellular Localization
    nucleus GO:0005634 TAS
    nucleoplasm GO:0005654 IDA
    chromosome GO:0005694 IEA
 Experiment description of studies that identified ZMYND11 in exosomes
1
Experiment ID 235
ISEV standards
EM
EV Biophysical techniques
TSG101|Alix|HSC70|GAPDH
EV Cytosolic markers
EV Membrane markers
HSP90B1
EV Negative markers
qNano
EV Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocellular carcinoma cells
Sample name HKCI-8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RT-PCR
RNA Sequencing
 Protein-protein interactions for ZMYND11
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ZHX1  
Two-hybrid Homo sapiens
2 BMPR1A  
Invivo Homo sapiens
Two-hybrid Homo sapiens
3 ETS2  
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Invivo Homo sapiens
Two-hybrid Homo sapiens
4 NCOR1  
Affinity Capture-Western Homo sapiens
5 C11orf30  
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Two-hybrid Homo sapiens
View the network image/svg+xml
 Pathways in which ZMYND11 is involved
No pathways found





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