Gene description for Ppp2ca
Gene name protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform
Gene symbol Ppp2ca
Other names/aliases PP2A
R75353
Species Mus musculus
 Database cross references - Ppp2ca
ExoCarta ExoCarta_19052
Vesiclepedia VP_19052
Entrez Gene 19052
UniProt P63330  
 Ppp2ca identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Ppp2ca
Molecular Function
    protein antigen binding GO:1990405 ISO
    protein binding GO:0005515 IPI
    protein dimerization activity GO:0046983 ISO
    ion channel binding GO:0044325 ISO
    phosphoprotein phosphatase activity GO:0004721 IEA
    protein kinase B binding GO:0043422 ISO
    protein C-terminus binding GO:0008022 ISO
    enzyme binding GO:0019899 ISO
    protein phosphatase binding GO:0019903 ISO
    hydrolase activity GO:0016787 IEA
    metal ion binding GO:0046872 IEA
    tau protein binding GO:0048156 ISO
    protein domain specific binding GO:0019904 ISO
    protein serine/threonine phosphatase activity GO:0004722 TAS
    protein complex binding GO:0032403 ISO
    protein kinase binding GO:0019901 ISO
    protein phosphatase 2A binding GO:0051721 ISO
    GABA receptor binding GO:0050811 IDA
Biological Process
    meiotic cell cycle GO:0051321 IEA
    regulation of protein autophosphorylation GO:0031952 ISO
    negative regulation of calcium ion transmembrane transporter activity GO:1901020 ISO
    mesoderm development GO:0007498 IMP
    positive regulation of protein dephosphorylation GO:0035307 ISO
    negative regulation of transcription factor import into nucleus GO:0042992 ISO
    negative regulation of protein phosphorylation GO:0001933 ISO
    regulation of cell cycle GO:0051726 TAS
    regulation of protein phosphorylation GO:0001932 ISO
    protein heterotrimerization GO:0070208 ISO
    regulation of receptor activity GO:0010469 ISO
    cellular response to glucose stimulus GO:0071333 ISO
    positive regulation of apoptotic process GO:0043065 ISO
    negative regulation of epithelial to mesenchymal transition GO:0010719 ISO
    negative regulation of transcription from RNA polymerase II promoter GO:0000122 ISO
    positive regulation of cysteine-type endopeptidase activity involved in apoptotic process GO:0043280 ISO
    protein dephosphorylation GO:0006470 TAS
    regulation of protein catabolic process GO:0042176 ISO
    positive regulation of protein serine/threonine kinase activity GO:0071902 ISO
    positive regulation of protein phosphatase type 2A activity GO:0034049 ISO
Subcellular Localization
    chromosome GO:0005694 IEA
    cytosol GO:0005829 ISO
    cytoplasm GO:0005737 IDA
    plasma membrane GO:0005886 IDA
    cytoskeleton GO:0005856 IEA
    protein phosphatase type 2A complex GO:0000159 ISO
    chromosome, centromeric region GO:0000775 IDA
    terminal bouton GO:0043195 ISO
    extracellular exosome GO:0070062 ISO
    nucleus GO:0005634 IEA
    postsynaptic density GO:0014069 ISO
    neuron projection GO:0043005 ISO
 Experiment description of studies that identified Ppp2ca in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Ppp2ca
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 BMPR1B 658
Affinity Capture-Luminescence Homo sapiens
View the network image/svg+xml



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