Gene description for Stk24
Gene name serine/threonine kinase 24
Gene symbol Stk24
Other names/aliases 1810013H02Rik
C76483
MST-3
Mst3
STE20
Species Mus musculus
 Database cross references - Stk24
ExoCarta ExoCarta_223255
Vesiclepedia VP_223255
Entrez Gene 223255
UniProt Q99KH8  
 Stk24 identified in exosomes derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Stk24
Molecular Function
    kinase activity GO:0016301 IEA
    metal ion binding GO:0046872 IEA
    nucleotide binding GO:0000166 IEA
    protein kinase activity GO:0004672 IEA
    protein serine/threonine kinase activity GO:0004674 ISO
    ATP binding GO:0005524 IEA
    transferase activity GO:0016740 IEA
    transferase activity, transferring phosphorus-containing groups GO:0016772 IEA
Biological Process
    protein autophosphorylation GO:0046777 ISO
    apoptotic process GO:0006915 IEA
    regulation of axon regeneration GO:0048679 ISO
    activation of protein kinase activity GO:0032147 IBA
    signal transduction by protein phosphorylation GO:0023014 IBA
    execution phase of apoptosis GO:0097194 ISO
    negative regulation of cell migration GO:0030336 ISO
    regulation of mitotic cell cycle GO:0007346 IBA
    response to hydrogen peroxide GO:0042542 ISO
    regulation of apoptotic process GO:0042981 IBA
    phosphorylation GO:0016310 IEA
    positive regulation of axon regeneration GO:0048680 ISO
    intrinsic apoptotic signaling pathway in response to oxidative stress GO:0008631 ISO
    protein phosphorylation GO:0006468 ISO
    stress-activated protein kinase signaling cascade GO:0031098 IBA
Subcellular Localization
    nucleus GO:0005634 ISO
    membrane GO:0016020 IEA
    nucleolus GO:0005730 ISO
    cytoplasm GO:0005737 ISO
    extracellular exosome GO:0070062 ISO
    Golgi membrane GO:0000139 ISO
 Experiment description of studies that identified Stk24 in exosomes
1
Experiment ID 907
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
EV Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
EV Enriched markers
✔
HSPA5
EV Negative markers
✔
NTA
EV Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S.
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Stk24
  Protein Interactor ExoCarta ID Identification method PubMed Species
No interactions are found.
 Pathways in which Stk24 is involved
PathwayEvidenceSource
Apoptotic execution phase IEA Reactome





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