Gene description for Pdcd10
Gene name programmed cell death 10
Gene symbol Pdcd10
Other names/aliases 2410003B13Rik
Ccm3
Tfa15
Tfar15
Species Mus musculus
 Database cross references - Pdcd10
ExoCarta ExoCarta_56426
Vesiclepedia VP_56426
Entrez Gene 56426
UniProt Q8VE70  
 Pdcd10 identified in sEVs derived from the following tissue/cell type
Colon cancer cells 37309723    
T-cell lymphoma cells 37309723    
 Gene ontology annotations for Pdcd10
Molecular Function
    protein binding GO:0005515 IPI
    protein kinase binding GO:0019901 IBA
    protein homodimerization activity GO:0042803 IEA
    protein homodimerization activity GO:0042803 ISO
Biological Process
    angiogenesis GO:0001525 IEA
    endothelium development GO:0003158 NAS
    short-term memory GO:0007614 ISO
    positive regulation of cell population proliferation GO:0008284 ISO
    positive regulation of cell population proliferation GO:0008284 ISS
    positive regulation of gene expression GO:0010628 IEA
    positive regulation of gene expression GO:0010628 ISO
    negative regulation of gene expression GO:0010629 IEA
    negative regulation of gene expression GO:0010629 ISO
    positive regulation of cell migration GO:0030335 IEA
    positive regulation of cell migration GO:0030335 ISO
    positive regulation of stress-activated MAPK cascade GO:0032874 IEA
    positive regulation of stress-activated MAPK cascade GO:0032874 ISO
    positive regulation of peptidyl-serine phosphorylation GO:0033138 ISO
    intracellular signal transduction GO:0035556 ISO
    intrinsic apoptotic signaling pathway in response to hydrogen peroxide GO:0036481 IEA
    intrinsic apoptotic signaling pathway in response to hydrogen peroxide GO:0036481 ISO
    negative regulation of apoptotic process GO:0043066 ISO
    negative regulation of apoptotic process GO:0043066 ISS
    positive regulation of MAP kinase activity GO:0043406 ISO
    positive regulation of MAP kinase activity GO:0043406 ISS
    wound healing, spreading of cells GO:0044319 IEA
    wound healing, spreading of cells GO:0044319 ISO
    positive regulation of Notch signaling pathway GO:0045747 IEA
    positive regulation of Notch signaling pathway GO:0045747 ISO
    regulation of angiogenesis GO:0045765 NAS
    negative regulation of inflammatory response GO:0050728 ISO
    protein stabilization GO:0050821 IEA
    protein stabilization GO:0050821 ISO
    establishment of Golgi localization GO:0051683 IEA
    establishment of Golgi localization GO:0051683 ISO
    cellular response to anoxia GO:0071454 ISO
    positive regulation of protein serine/threonine kinase activity GO:0071902 ISO
    negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 IEA
    negative regulation of cell migration involved in sprouting angiogenesis GO:0090051 ISO
    Golgi reassembly GO:0090168 IBA
    Golgi reassembly GO:0090168 IEA
    Golgi reassembly GO:0090168 ISO
    positive regulation of intracellular protein transport GO:0090316 ISO
    positive regulation of intracellular protein transport GO:0090316 ISS
    negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:1903588 IEA
    negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis GO:1903588 ISO
    cellular response to leukemia inhibitory factor GO:1990830 IEP
    positive regulation of mesenchymal cell apoptotic process GO:2001055 ISO
Subcellular Localization
    Golgi membrane GO:0000139 IEA
    Golgi membrane GO:0000139 ISO
    cytoplasm GO:0005737 ISO
    Golgi apparatus GO:0005794 ISO
    Golgi apparatus GO:0005794 ISO
    cytosol GO:0005829 ISO
    cytosol GO:0005829 ISS
    plasma membrane GO:0005886 IEA
    cell periphery GO:0071944 ISO
    FAR/SIN/STRIPAK complex GO:0090443 IBA
    FAR/SIN/STRIPAK complex GO:0090443 IEA
    FAR/SIN/STRIPAK complex GO:0090443 ISO
 Experiment description of studies that identified Pdcd10 in sEVs
1
Experiment ID 907
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample Colon cancer cells
Sample name C26
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
2
Experiment ID 908
MISEV standards
✔
EM
Biophysical techniques
✔
Tsg101|Sdcbp|Cd151|Gapdh|Lamp2|Cd81|Cd82|Cd9|Cd63|Cd80|Flot2|Tfrc|Rab35|Rab5a
Enriched markers
✔
HSPA5
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 37309723    
Organism Mus musculus
Experiment description Proteomic analysis of the small extracellular vesicles and soluble secretory proteins from cachexia inducing and non-inducing cancer cells
Authors "Chitti SV, Kang T, Fonseka P, Marzan AL, Stewart S, Shahi S, Bramich K, Ang CS, Pathan M, Gummadi S, Mathivanan S."
Journal name Proteomics
Publication year 2023
Sample T-cell lymphoma cells
Sample name EL4
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectrometry
 Protein-protein interactions for Pdcd10
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 Fitm2  
Negative Genetic Mus musculus
2 Atg12  
Negative Genetic Mus musculus
3 Stk24 223255
Co-fractionation Mus musculus
4 Unk  
Affinity Capture-RNA Mus musculus
View the network image/svg+xml
 Pathways in which Pdcd10 is involved
No pathways found





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