Gene description for Cct7
Gene name chaperonin containing Tcp1, subunit 7 (eta)
Gene symbol Cct7
Other names/aliases AA408524
AL022769
Ccth
Cctz
Species Mus musculus
 Database cross references - Cct7
ExoCarta ExoCarta_12468
Entrez Gene 12468
UniProt P80313  
 Cct7 identified in exosomes derived from the following tissue/cell type
Fibroblasts 23260141    
Mast cells 17486113    
 Gene ontology annotations for Cct7
Molecular Function
    unfolded protein binding GO:0051082 IEA
    nucleotide binding GO:0000166 IEA
    protein binding GO:0005515 IPI
    ATP binding GO:0005524 IEA
    identical protein binding GO:0042802 IPI
Biological Process
    binding of sperm to zona pellucida GO:0007339 IDA
    protein folding GO:0006457 IEA
    toxin transport GO:1901998 IMP
Subcellular Localization
    microtubule GO:0005874 ISO
    cytoplasm GO:0005737 IEA
    mitochondrion GO:0005739 IDA
    zona pellucida receptor complex GO:0002199 IDA
    chaperonin-containing T-complex GO:0005832 ISO
    extracellular exosome GO:0070062 ISO
    cell body GO:0044297 IDA
 Experiment description of studies that identified Cct7 in exosomes
1
Experiment ID 210
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD81|FLOT1
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 23260141    
Organism Mus musculus
Experiment description Exosomes Mediate Stromal Mobilization of Autocrine Wnt-PCP Signaling in Breast Cancer Cell Migration.
Authors Luga V, Zhang L, Viloria-Petit AM, Ogunjimi AA, Inanlou MR, Chiu E, Buchanan M, Hosein AN, Basik M, Wrana JL.
Journal name Cell
Publication year 2012
Sample Fibroblasts
Sample name Normal-Fibroblasts (L cells)
Isolation/purification methods Differential centrifugation
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry
2
Experiment ID 15
ISEV standards
EM
EV Biophysical techniques
EV Cytosolic markers
CD63
EV Membrane markers
EV Negative markers
EV Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 17486113    
Organism Mus musculus
Homo sapiens
Experiment description Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells.
Authors Valadi H, Ekstrom K, Bossios A, Sjostrand M, Lee JJ, Lotvall JO
Journal name NCB
Publication year 2007
Sample Mast cells
Sample name MC9
Bone marrow-derived mast cells
HMC-1
Isolation/purification methods Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.11-1.21 g/mL
Molecules identified in the study Protein
mRNA
miRNA
Methods used in the study Mass spectrometry [MALDI TOF]
Western blotting
Microarray
miRCURY LNA Array
 Protein-protein interactions for Cct7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ACTB 60
Reconstituted Complex Homo sapiens
View the network image/svg+xml



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