Gene description for PDCL3
Gene name phosducin-like 3
Gene symbol PDCL3
Other names/aliases HTPHLP
PHLP2A
PHLP3
VIAF
VIAF1
Species Homo sapiens
 Database cross references - PDCL3
ExoCarta ExoCarta_79031
Vesiclepedia VP_79031
Entrez Gene 79031
HGNC 28860
MIM 611678
UniProt Q9H2J4  
 PDCL3 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Chondrocytes 35931686    
Chondrocytes 35931686    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for PDCL3
Molecular Function
    protein binding GO:0005515 IPI
    vascular endothelial growth factor receptor 2 binding GO:0043184 IBA
    protein folding chaperone GO:0044183 IBA
    protein folding chaperone GO:0044183 IMP
    protein folding chaperone GO:0044183 IPI
Biological Process
    angiogenesis GO:0001525 IBA
    angiogenesis GO:0001525 IMP
    positive regulation of endothelial cell proliferation GO:0001938 IMP
    protein folding GO:0006457 IBA
    apoptotic process GO:0006915 IEA
    positive regulation of gene expression GO:0010628 IBA
    positive regulation of gene expression GO:0010628 IMP
    actin cytoskeleton organization GO:0030036 IMP
    positive regulation of angiogenesis GO:0045766 IMP
    regulation of peptidyl-tyrosine phosphorylation GO:0050730 IMP
    protein stabilization GO:0050821 IMP
    chaperone-mediated protein folding GO:0061077 IMP
    negative regulation of chaperone-mediated protein folding GO:1903645 IMP
    negative regulation of ubiquitin-dependent protein catabolic process GO:2000059 IMP
Subcellular Localization
    nucleoplasm GO:0005654 IDA
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    endoplasmic reticulum GO:0005783 IDA
    cytosol GO:0005829 IDA
    protein-containing complex GO:0032991 IEA
    perinuclear region of cytoplasm GO:0048471 IEA
    perinucleolar compartment GO:0097356 IDA
 Experiment description of studies that identified PDCL3 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 497
MISEV standards
Biophysical techniques
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 498
MISEV standards
EM
Biophysical techniques
CD9|CD151|CD63|CD81|CD82|FLOT1|FLOT2|GAPDH|LAMP1|LAMP2|RAB5A|SDCBP|TFRC|TSG101|UCHL1
Enriched markers
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 35931686    
Organism Homo sapiens
Experiment description Extracellular vesicles enriched in connexin 43 promote a senescent phenotype in bone and synovial cells contributing to osteoarthritis progression
Authors "Varela-Eirín M, Carpintero-Fernández P, Guitián-Caamaño A, Varela-Vázquez A, García-Yuste A, Sánchez-Temprano A, Bravo-López SB, Yañez-Cabanas J, Fonseca E, Largo R, Mobasheri A, Caeiro JR, Mayán MD."
Journal name Cell Death Dis
Publication year 2022
Sample Chondrocytes
Sample name T/C-28a2
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
7
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PDCL3
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ACTRT2  
Affinity Capture-MS Homo sapiens
2 FBXW8 26259
Affinity Capture-MS Homo sapiens
3 ACTR2 10097
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
4 UTRN 7402
Affinity Capture-MS Homo sapiens
5 CCT3 7203
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
6 QARS 5859
Co-fractionation Homo sapiens
7 JMJD4  
Affinity Capture-MS Homo sapiens
8 PEX7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
9 ACTC1 70
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
10 CCT4 10575
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 CCT6B 10693
Affinity Capture-MS Homo sapiens
12 PLAC8L1  
Affinity Capture-MS Homo sapiens
13 Cct2 12461
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
14 POTEF 728378
Affinity Capture-MS Homo sapiens
15 KIAA1429 25962
Affinity Capture-MS Homo sapiens
16 FBXW4 6468
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 WDR86  
Affinity Capture-MS Homo sapiens
18 WDR74 54663
Affinity Capture-MS Homo sapiens
19 C8orf82  
Proximity Label-MS Homo sapiens
20 ACTR1A 10121
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 MLST8 64223
Affinity Capture-MS Homo sapiens
22 PTER 9317
Affinity Capture-MS Homo sapiens
23 KLHL33  
Affinity Capture-MS Homo sapiens
24 KDR  
Reconstituted Complex Homo sapiens
25 PRDX2 7001
Affinity Capture-MS Homo sapiens
26 TATDN1 83940
Affinity Capture-MS Homo sapiens
27 PDCL2  
Affinity Capture-MS Homo sapiens
28 Cct4 12464
Affinity Capture-MS Mus musculus
29 KIF14 9928
Affinity Capture-MS Homo sapiens
30 CCT2 10576
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
31 ACTA2 59
Affinity Capture-MS Homo sapiens
32 DLD 1738
Affinity Capture-MS Homo sapiens
33 TCP1 6950
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 FOXA1  
Affinity Capture-MS Homo sapiens
35 SAMM50 25813
Proximity Label-MS Homo sapiens
36 WDR70 55100
Affinity Capture-MS Homo sapiens
37 WDR89  
Affinity Capture-MS Homo sapiens
38 Cct7 12468
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
39 CCT5 22948
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
40 DCAF12 25853
Affinity Capture-MS Homo sapiens
41 PDCD5 9141
Affinity Capture-MS Homo sapiens
42 KLHDC8B 200942
Affinity Capture-MS Homo sapiens
43 BICD2 23299
Proximity Label-MS Homo sapiens
44 ACTB 60
Affinity Capture-MS Homo sapiens
45 ACTG1 71
Affinity Capture-MS Homo sapiens
46 DTL  
Affinity Capture-MS Homo sapiens
47 Cct3 12462
Affinity Capture-MS Mus musculus
Affinity Capture-MS Mus musculus
48 POTEI 653269
Affinity Capture-MS Homo sapiens
49 MTX2 10651
Proximity Label-MS Homo sapiens
50 CCT6A 908
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 USP54 159195
Affinity Capture-MS Homo sapiens
52 ACTBL2 345651
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 DCAF13 25879
Affinity Capture-MS Homo sapiens
54 DDB2  
Affinity Capture-MS Homo sapiens
55 PGAM4 441531
Affinity Capture-MS Homo sapiens
56 SLC25A48  
Affinity Capture-MS Homo sapiens
57 NUP43 348995
Proximity Label-MS Homo sapiens
58 TXNDC9 10190
Affinity Capture-MS Homo sapiens
59 PRKCSH 5589
Co-fractionation Homo sapiens
60 RPA3 6119
Proximity Label-MS Homo sapiens
61 GNB2 2783
Affinity Capture-MS Homo sapiens
62 Cct8 12469
Affinity Capture-MS Mus musculus
63 NDUFA3  
Affinity Capture-MS Homo sapiens
64 CSF1R  
Affinity Capture-Western Homo sapiens
65 PFDN5 5204
Affinity Capture-MS Homo sapiens
66 FBXW11  
Affinity Capture-MS Homo sapiens
67 MSTO1 55154
Affinity Capture-MS Homo sapiens
68 CCT8 10694
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 TUBG1 7283
Affinity Capture-MS Homo sapiens
70 KLHL8  
Affinity Capture-MS Homo sapiens
71 PDCL 5082
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
72 PNPLA1 285848
Affinity Capture-MS Homo sapiens
73 PFDN1 5201
Affinity Capture-MS Homo sapiens
74 WRAP53  
Affinity Capture-MS Homo sapiens
75 ACTR1B 10120
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
76 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
77 ACTRT1  
Affinity Capture-MS Homo sapiens
78 SHMT2 6472
Affinity Capture-RNA Homo sapiens
79 CCT7 10574
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
80 ZNF691  
Affinity Capture-MS Homo sapiens
81 Actr1b 226977
Affinity Capture-MS Mus musculus
82 NEDD1 121441
Affinity Capture-MS Homo sapiens
83 TUBD1  
Affinity Capture-MS Homo sapiens
84 TAF1C  
Affinity Capture-MS Homo sapiens
85 ACTRT3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
86 DCAF5  
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PDCL3 is involved
No pathways found





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