Gene description for PDCL
Gene name phosducin-like
Gene symbol PDCL
Other names/aliases PhLP
Species Homo sapiens
 Database cross references - PDCL
ExoCarta ExoCarta_5082
Vesiclepedia VP_5082
Entrez Gene 5082
HGNC 8770
MIM 604421
UniProt Q13371  
 PDCL identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for PDCL
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    signal transduction GO:0007165 NAS
    visual perception GO:0007601 IEA
    regulation of G protein-coupled receptor signaling pathway GO:0008277 IEA
    cell projection organization GO:0030030 IEA
    positive regulation of smoothened signaling pathway GO:0045880 ISS
    heterotrimeric G-protein complex assembly GO:1902605 IBA
Subcellular Localization
    cytoplasm GO:0005737 IBA
    cytoplasm GO:0005737 IDA
    cytosol GO:0005829 TAS
    cilium GO:0005929 IEA
 Experiment description of studies that identified PDCL in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PDCL
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 ADRBK1 156
Biochemical Activity Homo sapiens
2 HSD17B11 51170
Proximity Label-MS Homo sapiens
3 GNG10 2790
Affinity Capture-MS Homo sapiens
4 MTCH1 23787
Proximity Label-MS Homo sapiens
5 CCT3 7203
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
6 QARS 5859
Affinity Capture-MS Homo sapiens
7 CG8258 35882
Affinity Capture-MS Drosophila melanogaster
Co-crystal Structure Drosophila melanogaster
8 METTL7A 25840
Proximity Label-MS Homo sapiens
9 DYNC1I2 1781
Proximity Label-MS Homo sapiens
10 GNG4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
11 Tcp-1eta 41054
Affinity Capture-MS Drosophila melanogaster
Co-crystal Structure Drosophila melanogaster
12 GBA3 57733
Affinity Capture-MS Homo sapiens
13 GJD3  
Proximity Label-MS Homo sapiens
14 C4orf26  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
15 T-cp1 42649
Affinity Capture-MS Drosophila melanogaster
Co-crystal Structure Drosophila melanogaster
16 ENDOV  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 LRRC59 55379
Proximity Label-MS Homo sapiens
18 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
19 PLAC8L1  
Affinity Capture-MS Homo sapiens
20 GNGT1  
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
21 Tcp-1zeta 32518
Affinity Capture-MS Drosophila melanogaster
Co-crystal Structure Drosophila melanogaster
22 Cct2 12461
Affinity Capture-MS Mus musculus
23 WDTC1 23038
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 Gnb1 14688
Affinity Capture-MS Mus musculus
25 FBXW4 6468
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
26 WDR86  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 GNG12 55970
Affinity Capture-MS Homo sapiens
28 FIS1 51024
Proximity Label-MS Homo sapiens
29 RAB3B 5865
Proximity Label-MS Homo sapiens
30 SUV39H1  
Affinity Capture-MS Homo sapiens
31 SSR1 6745
Proximity Label-MS Homo sapiens
32 KLHL33  
Affinity Capture-MS Homo sapiens
33 PRDX2 7001
Affinity Capture-MS Homo sapiens
34 EXD2  
Proximity Label-MS Homo sapiens
35 TULP3 7289
Affinity Capture-MS Homo sapiens
36 SLC25A46 91137
Proximity Label-MS Homo sapiens
37 CG5525  
Affinity Capture-MS Drosophila melanogaster
Co-crystal Structure Drosophila melanogaster
38 CG7033  
Affinity Capture-MS Drosophila melanogaster
Co-crystal Structure Drosophila melanogaster
39 MAVS 57506
Proximity Label-MS Homo sapiens
40 Cct4 12464
Affinity Capture-MS Mus musculus
41 GNB5 10681
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
42 PEX7  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
43 GNG3 2785
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
44 CCT2 10576
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 KIAA1715 80856
Proximity Label-MS Homo sapiens
46 PXMP2  
Proximity Label-MS Homo sapiens
47 Cct3 12462
Affinity Capture-MS Mus musculus
48 NF2 4771
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
49 MTCH2 23788
Proximity Label-MS Homo sapiens
50 SAMM50 25813
Proximity Label-MS Homo sapiens
51 LRRC10  
Affinity Capture-MS Homo sapiens
52 B4GALT2  
Affinity Capture-MS Homo sapiens
53 Cct7 12468
Affinity Capture-MS Mus musculus
54 CCT5 22948
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
55 BAG6 7917
Affinity Capture-MS Homo sapiens
56 POC1A  
Affinity Capture-MS Homo sapiens
57 ACTR3B 57180
Affinity Capture-MS Homo sapiens
58 SP110  
Affinity Capture-MS Homo sapiens
59 ACTL6A 86
Affinity Capture-MS Homo sapiens
60 SYNCRIP 10492
Affinity Capture-MS Homo sapiens
61 RPN1 6184
Proximity Label-MS Homo sapiens
62 MRPL11 65003
Two-hybrid Homo sapiens
63 RHOT2 89941
Proximity Label-MS Homo sapiens
64 ELOVL5 60481
Proximity Label-MS Homo sapiens
65 SEC61B 10952
Proximity Label-MS Homo sapiens
66 RAP2C 57826
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
67 RMDN3 55177
Proximity Label-MS Homo sapiens
68 MYH7B  
Affinity Capture-MS Homo sapiens
69 DNAJC25-GNG10  
Affinity Capture-MS Homo sapiens
70 HNRNPD 3184
Affinity Capture-MS Homo sapiens
71 MMACHC  
Affinity Capture-MS Homo sapiens
72 GNB4 59345
Affinity Capture-Western Homo sapiens
73 XPO1 7514
Affinity Capture-MS Homo sapiens
74 EGLN3  
Affinity Capture-MS Homo sapiens
75 MTX2 10651
Proximity Label-MS Homo sapiens
76 CCT6A 908
Affinity Capture-MS Homo sapiens
77 MEX3A  
Affinity Capture-RNA Homo sapiens
78 STIM1 6786
Proximity Label-MS Homo sapiens
79 PGAM4 441531
Affinity Capture-MS Homo sapiens
80 SLC25A48  
Affinity Capture-MS Homo sapiens
81 FKBP8 23770
Affinity Capture-Luminescence Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
82 GNB3 2784
Affinity Capture-Western Homo sapiens
83 NXNL2  
Affinity Capture-MS Homo sapiens
84 OCIAD1 54940
Proximity Label-MS Homo sapiens
85 Cct5  
Affinity Capture-MS Drosophila melanogaster
Co-crystal Structure Drosophila melanogaster
86 SGTB  
Affinity Capture-MS Homo sapiens
87 NUP43 348995
Proximity Label-MS Homo sapiens
88 GNG11 2791
Affinity Capture-MS Homo sapiens
89 Cctgamma 42029
Affinity Capture-Western Drosophila melanogaster
90 GNB2 2783
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
91 PTPN1 5770
Proximity Label-MS Homo sapiens
92 PSMC5 5705
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
93 Cct8 12469
Affinity Capture-MS Mus musculus
94 CYP2C9  
Proximity Label-MS Homo sapiens
95 FBXW5  
Affinity Capture-MS Homo sapiens
96 AKAP1 8165
Proximity Label-MS Homo sapiens
97 HUWE1 10075
Affinity Capture-MS Homo sapiens
98 TTLL3 26140
Affinity Capture-MS Homo sapiens
99 GNG2 54331
Affinity Capture-MS Homo sapiens
100 PHB2 11331
Proximity Label-MS Homo sapiens
101 CCT8 10694
Affinity Capture-MS Homo sapiens
102 PDCL3 79031
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
103 TUBG2  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
104 PNPLA1 285848
Affinity Capture-MS Homo sapiens
105 IKBKG 8517
Reconstituted Complex Homo sapiens
106 CDK15  
Affinity Capture-MS Homo sapiens
107 PPP2R2C 5522
Affinity Capture-MS Homo sapiens
108 GNB1 2782
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Co-crystal Structure Homo sapiens
109 GNG5 2787
Affinity Capture-MS Homo sapiens
110 CCT7 10574
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
111 KLHDC8A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
112 SEC62 7095
Proximity Label-MS Homo sapiens
113 RAB11A 8766
Proximity Label-MS Homo sapiens
114 DNAJC1 64215
Proximity Label-MS Homo sapiens
115 KRAS 3845
Negative Genetic Homo sapiens
116 NUP210P1  
Affinity Capture-MS Homo sapiens
117 CKAP4 10970
Proximity Label-MS Homo sapiens
118 ODF1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
119 CCT4 10575
Affinity Capture-MS Homo sapiens
120 DERL1 79139
Proximity Label-MS Homo sapiens
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