Gene description for SAMM50
Gene name SAMM50 sorting and assembly machinery component
Gene symbol SAMM50
Other names/aliases CGI-51
OMP85
SAM50
TOB55
TRG-3
YNL026W
Species Homo sapiens
 Database cross references - SAMM50
ExoCarta ExoCarta_25813
Vesiclepedia VP_25813
Entrez Gene 25813
HGNC 24276
MIM 612058
UniProt Q9Y512  
 SAMM50 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
Urine 15326289    
Urine 19056867    
 Gene ontology annotations for SAMM50
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    inner mitochondrial membrane organization GO:0007007 IC
    mitochondrial respiratory chain complex assembly GO:0033108 IBA
    mitochondrial respiratory chain complex assembly GO:0033108 IMP
    cristae formation GO:0042407 IMP
    protein insertion into mitochondrial outer membrane GO:0045040 IBA
    protein insertion into mitochondrial outer membrane GO:0045040 IDA
    protein insertion into mitochondrial outer membrane GO:0045040 NAS
Subcellular Localization
    SAM complex GO:0001401 HDA
    SAM complex GO:0001401 IMP
    SAM complex GO:0001401 IPI
    mitochondrion GO:0005739 HDA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrial outer membrane GO:0005741 IDA
    mitochondrial outer membrane GO:0005741 NAS
    membrane GO:0016020 IDA
    extracellular exosome GO:0070062 HDA
    MIB complex GO:0140275 HDA
 Experiment description of studies that identified SAMM50 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
6
Experiment ID 13
MISEV standards
IEM
Biophysical techniques
Alix|RAB4|RAB5B|RAB11|TSG101|CD9|AQP2|AQP1
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 15326289    
Organism Homo sapiens
Experiment description Identification and proteomic profiling of exosomes in human urine.
Authors "Pisitkun T, Shen RF, Knepper MA"
Journal name PNAS
Publication year 2004
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LCQ DECA XP]
Western blotting
7
Experiment ID 63
MISEV standards
Biophysical techniques
AQP2
Enriched markers
Negative markers
Particle analysis
Identified molecule protein
Identification method Mass spectrometry
PubMed ID 19056867    
Organism Homo sapiens
Experiment description Large-scale proteomics and phosphoproteomics of urinary exosomes.
Authors "Gonzales PA, Pisitkun T, Hoffert JD, Tchapyjnikov D, Star RA, Kleta R, Wang NS, Knepper MA"
Journal name JASN
Publication year 2009
Sample Urine
Sample name Urine - Normal
Isolation/purification methods Differential centrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Mass spectrometry [LTQ]
Western blotting
 Protein-protein interactions for SAMM50
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 UBE2H 7328
Affinity Capture-MS Homo sapiens
2 A1BG 1
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
3 MAP1LC3C  
Reconstituted Complex Homo sapiens
4 AFG3L2 10939
Proximity Label-MS Homo sapiens
5 NDUFB8 4714
Co-fractionation Homo sapiens
6 SPRTN  
Affinity Capture-MS Homo sapiens
7 SLC22A8 9376
Affinity Capture-MS Homo sapiens
8 Mtx2  
Affinity Capture-MS Mus musculus
9 ANLN 54443
Affinity Capture-MS Homo sapiens
10 MTX1 4580
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
11 NUDCD3 23386
Proximity Label-MS Homo sapiens
12 SLC2A1 6513
Affinity Capture-MS Homo sapiens
13 SPSB4  
Affinity Capture-MS Homo sapiens
14 KIF20A 10112
Affinity Capture-MS Homo sapiens
15 CCT4 10575
Proximity Label-MS Homo sapiens
16 NDUFA4 4697
Affinity Capture-MS Homo sapiens
17 TMEM72  
Affinity Capture-MS Homo sapiens
18 FKBP4 2288
Proximity Label-MS Homo sapiens
19 LRRN4CL 221091
Affinity Capture-MS Homo sapiens
20 FFAR1  
Affinity Capture-MS Homo sapiens
21 RPAP3 79657
Proximity Label-MS Homo sapiens
22 CCDC90B  
Proximity Label-MS Homo sapiens
23 PDE2A  
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
24 TOMM22 56993
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
25 MAP1LC3B 81631
Reconstituted Complex Homo sapiens
26 HDAC3 8841
Proximity Label-MS Homo sapiens
27 FIS1 51024
Proximity Label-MS Homo sapiens
28 NDUFS3 4722
Co-fractionation Homo sapiens
29 B3GNT2 10678
Affinity Capture-MS Homo sapiens
30 KIF23 9493
Affinity Capture-MS Homo sapiens
31 DNAJC11 55735
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
32 TIMMDC1  
Affinity Capture-MS Homo sapiens
33 CCDC138  
Proximity Label-MS Homo sapiens
34 TRABD 80305
Proximity Label-MS Homo sapiens
35 CCT3 7203
Proximity Label-MS Homo sapiens
36 PFDN4 5203
Proximity Label-MS Homo sapiens
37 P2RY8  
Affinity Capture-MS Homo sapiens
38 SURF1  
Proximity Label-MS Homo sapiens
Co-fractionation Homo sapiens
39 STIP1 10963
Proximity Label-MS Homo sapiens
40 USP33  
Proximity Label-MS Homo sapiens
41 DNAJC7 7266
Proximity Label-MS Homo sapiens
42 TOMM40 10452
Reconstituted Complex Homo sapiens
Co-fractionation Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
43 CCT7 10574
Proximity Label-MS Homo sapiens
44 MAVS 57506
Proximity Label-MS Homo sapiens
45 TCP1 6950
Proximity Label-MS Homo sapiens
46 WDR6 11180
Proximity Label-MS Homo sapiens
47 Erh  
Affinity Capture-MS Mus musculus
48 KIF14 9928
Affinity Capture-MS Homo sapiens
49 HSPA8 3312
Co-fractionation Homo sapiens
50 CCT2 10576
Proximity Label-MS Homo sapiens
51 APOO 79135
Proximity Label-MS Homo sapiens
52 BAG5 9529
Proximity Label-MS Homo sapiens
53 RPS23 6228
Co-fractionation Homo sapiens
54 PCNT  
Proximity Label-MS Homo sapiens
55 EGLN3  
Affinity Capture-MS Homo sapiens
56 MTCH2 23788
Proximity Label-MS Homo sapiens
57 MIB1 57534
Proximity Label-MS Homo sapiens
58 COX15 1355
Proximity Label-MS Homo sapiens
59 DUOXA2  
Affinity Capture-MS Homo sapiens
60 PARK2  
Affinity Capture-MS Homo sapiens
61 CACNG7  
Affinity Capture-MS Homo sapiens
62 CHCHD3 54927
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Two-hybrid Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
63 SLC2A8 29988
Affinity Capture-MS Homo sapiens
64 TMEM150A  
Affinity Capture-MS Homo sapiens
65 CCT5 22948
Proximity Label-MS Homo sapiens
66 BAG6 7917
Proximity Label-MS Homo sapiens
67 DIABLO 56616
Proximity Label-MS Homo sapiens
68 PFDN5 5204
Proximity Label-MS Homo sapiens
69 PDCD5 9141
Proximity Label-MS Homo sapiens
70 CHMP4B 128866
Affinity Capture-MS Homo sapiens
71 GABARAP 11337
Reconstituted Complex Homo sapiens
72 DTL  
Proximity Label-MS Homo sapiens
73 OPA1 4976
Proximity Label-MS Homo sapiens
74 EXOC6 54536
Affinity Capture-MS Homo sapiens
75 MOV10 4343
Proximity Label-MS Homo sapiens
76 MEOX2  
Two-hybrid Homo sapiens
77 CYC1 1537
Co-fractionation Homo sapiens
78 SLC25A17 10478
Co-fractionation Homo sapiens
79 CHCHD6 84303
Proximity Label-MS Homo sapiens
80 MRPL11 65003
Co-fractionation Homo sapiens
81 DNAJC30  
Proximity Label-MS Homo sapiens
82 SLAMF8  
Affinity Capture-MS Homo sapiens
83 RHOT2 89941
Co-fractionation Homo sapiens
Proximity Label-MS Homo sapiens
84 MFF 56947
Proximity Label-MS Homo sapiens
85 DNM1L 10059
Proximity Label-MS Homo sapiens
86 CACYBP 27101
Proximity Label-MS Homo sapiens
87 COX4I1 1327
Proximity Label-MS Homo sapiens
88 SQRDL 58472
Co-fractionation Homo sapiens
89 DUSP22  
Affinity Capture-MS Homo sapiens
90 CLEC5A  
Affinity Capture-MS Homo sapiens
91 C15orf48  
Affinity Capture-MS Homo sapiens
92 TMPO 7112
Affinity Capture-MS Homo sapiens
93 TXNDC9 10190
Proximity Label-MS Homo sapiens
94 SLC25A12 8604
Proximity Label-MS Homo sapiens
95 MINOS1  
Affinity Capture-MS Homo sapiens
96 RAB7A 7879
Proximity Label-MS Homo sapiens
97 SDHA 6389
Co-fractionation Homo sapiens
98 PINK1  
Affinity Capture-Western Homo sapiens
99 ECT2 1894
Affinity Capture-MS Homo sapiens
100 MRPS11  
Co-fractionation Homo sapiens
101 MTX2 10651
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
102 CCT6A 908
Proximity Label-MS Homo sapiens
103 MGARP  
Affinity Capture-MS Homo sapiens
104 RMND1 55005
Proximity Label-MS Homo sapiens
105 EGFR 1956
Affinity Capture-MS Homo sapiens
Negative Genetic Homo sapiens
106 FKBP8 23770
Proximity Label-MS Homo sapiens
107 AQP3  
Affinity Capture-MS Homo sapiens
108 HNRNPUL1 11100
Co-fractionation Homo sapiens
109 SUZ12  
Affinity Capture-MS Homo sapiens
110 OCIAD1 54940
Proximity Label-MS Homo sapiens
Proximity Label-MS Homo sapiens
111 FAM134C 162427
Affinity Capture-MS Homo sapiens
112 NEFL 4747
Proximity Label-MS Homo sapiens
113 RPA3 6119
Proximity Label-MS Homo sapiens
114 APOOL 139322
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
115 GPR45  
Affinity Capture-MS Homo sapiens
116 C19orf70  
Affinity Capture-MS Homo sapiens
117 TXNL1 9352
Proximity Label-MS Homo sapiens
118 CD244 51744
Affinity Capture-MS Homo sapiens
119 CLPB 81570
Proximity Label-MS Homo sapiens
120 VDAC1 7416
Reconstituted Complex Homo sapiens
Affinity Capture-MS Homo sapiens
121 VBP1 7411
Proximity Label-MS Homo sapiens
122 RNF26  
Affinity Capture-MS Homo sapiens
123 FAXC  
Affinity Capture-MS Homo sapiens
124 MTM1 4534
Affinity Capture-MS Homo sapiens
125 AKAP1 8165
Proximity Label-MS Homo sapiens
126 GBAS 2631
Affinity Capture-MS Homo sapiens
127 IMMT 10989
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-Western Homo sapiens
128 TRAK2 66008
Affinity Capture-MS Homo sapiens
129 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
130 SERINC1 57515
Co-fractionation Homo sapiens
131 NAAA  
Affinity Capture-MS Homo sapiens
132 CDC20 991
Proximity Label-MS Homo sapiens
133 PDCL3 79031
Proximity Label-MS Homo sapiens
134 TRAK1 22906
Affinity Capture-MS Homo sapiens
135 MFSD4  
Affinity Capture-MS Homo sapiens
136 PDCL 5082
Proximity Label-MS Homo sapiens
137 DNAJA2 10294
Proximity Label-MS Homo sapiens
138 LONP1 9361
Proximity Label-MS Homo sapiens
139 WDR92 116143
Proximity Label-MS Homo sapiens
140 CDC37 11140
Proximity Label-MS Homo sapiens
141 PFDN1 5201
Proximity Label-MS Homo sapiens
142 WRAP53  
Proximity Label-MS Homo sapiens
143 HNRNPM 4670
Co-fractionation Homo sapiens
144 SQSTM1 8878
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-MS Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
145 GPR3  
Affinity Capture-MS Homo sapiens
146 GNB1 2782
Proximity Label-MS Homo sapiens
147 SSBP1 6742
Co-fractionation Homo sapiens
148 TRAP1 10131
Affinity Capture-MS Homo sapiens
149 UFL1 23376
Affinity Capture-MS Homo sapiens
150 RAB8A 4218
Affinity Capture-MS Homo sapiens
151 NIPSNAP1 8508
Affinity Capture-MS Homo sapiens
152 MAP1LC3A 84557
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
153 NDUFS8 4728
Co-fractionation Homo sapiens
154 HM13 81502
Affinity Capture-MS Homo sapiens
155 C19orf52  
Proximity Label-MS Homo sapiens
156 SLC25A51  
Proximity Label-MS Homo sapiens
157 KRAS 3845
Synthetic Lethality Homo sapiens
Negative Genetic Homo sapiens
158 LRRC49  
Proximity Label-MS Homo sapiens
159 PCNP 57092
Affinity Capture-MS Homo sapiens
160 MAP1LC3B2  
Affinity Capture-MS Homo sapiens
161 S1PR4  
Affinity Capture-MS Homo sapiens
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