Gene description for DNAJC11
Gene name DnaJ (Hsp40) homolog, subfamily C, member 11
Gene symbol DNAJC11
Other names/aliases dJ126A5.1
Species Homo sapiens
 Database cross references - DNAJC11
ExoCarta ExoCarta_55735
Vesiclepedia VP_55735
Entrez Gene 55735
HGNC 25570
MIM 614827
UniProt Q9NVH1  
 DNAJC11 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Hepatocytes 26054723    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for DNAJC11
Molecular Function
    protein binding GO:0005515 IPI
Biological Process
    inner mitochondrial membrane organization GO:0007007 IC
    cristae formation GO:0042407 IBA
    cristae formation GO:0042407 IMP
Subcellular Localization
    SAM complex GO:0001401 HDA
    SAM complex GO:0001401 IDA
    nucleoplasm GO:0005654 IDA
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IDA
    mitochondrial outer membrane GO:0005741 IMP
    nuclear speck GO:0016607 IDA
    MICOS complex GO:0061617 IDA
    MIB complex GO:0140275 HDA
 Experiment description of studies that identified DNAJC11 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 237
MISEV standards
✔
EM
Biophysical techniques
✔
TSG101|Alix|HSC70|GAPDH
Enriched markers
✔
HSP90B1
Negative markers
✔
qNano
Particle analysis
Identified molecule mRNA
Identification method RNA Sequencing
PubMed ID 26054723    
Organism Homo sapiens
Experiment description Hepatocellular carcinoma-derived exosomes promote motility of immortalized hepatocyte through transfer of oncogenic proteins and RNAs
Authors "He M, Qin H, Poon TC, Sze SC, Ding X, Co NN, Ngai SM, Chan TF, Wong N"
Journal name Carcinogenesis
Publication year 2015
Sample Hepatocytes
Sample name MIHA
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Sucrose density gradient
Flotation density 1.13-1.19 g/mL
Molecules identified in the study Protein
RNA
Methods used in the study Western blotting
Mass spectrometry
RNA Sequencing
6
Experiment ID 488
MISEV standards
✔
EM
Biophysical techniques
✔
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
✔
CANX
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for DNAJC11
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 RALY 22913
Co-fractionation Homo sapiens
2 SLFN11 91607
Affinity Capture-MS Homo sapiens
3 RPS6KA5 9252
Two-hybrid Homo sapiens
4 TUSC2  
Affinity Capture-MS Homo sapiens
5 HNRNPC 3183
Co-fractionation Homo sapiens
6 SPRTN  
Affinity Capture-MS Homo sapiens
7 MTCH1 23787
Proximity Label-MS Homo sapiens
8 TCEB1 6921
Affinity Capture-MS Homo sapiens
9 SYNGR1 9145
Affinity Capture-MS Homo sapiens
10 YTHDF1 54915
Affinity Capture-MS Homo sapiens
11 SGCA  
Affinity Capture-MS Homo sapiens
12 BBS7 55212
Proximity Label-MS Homo sapiens
13 MME 4311
Co-fractionation Homo sapiens
14 ZNHIT2 741
Affinity Capture-MS Homo sapiens
15 TMEM184A  
Affinity Capture-MS Homo sapiens
16 NKIRAS2  
Cross-Linking-MS (XL-MS) Homo sapiens
Cross-Linking-MS (XL-MS) Homo sapiens
17 SYNE4  
Affinity Capture-MS Homo sapiens
18 TMEM72  
Affinity Capture-MS Homo sapiens
19 FKBP4 2288
Affinity Capture-MS Homo sapiens
20 FFAR1  
Affinity Capture-MS Homo sapiens
21 HEPACAM2  
Affinity Capture-MS Homo sapiens
22 TOMM22 56993
Co-fractionation Homo sapiens
23 PPTC7 160760
Affinity Capture-MS Homo sapiens
24 WDR73  
Affinity Capture-MS Homo sapiens
25 FIS1 51024
Proximity Label-MS Homo sapiens
26 EMILIN1 11117
Affinity Capture-MS Homo sapiens
27 GRPEL1 80273
Affinity Capture-MS Homo sapiens
28 PITPNB 23760
Affinity Capture-MS Homo sapiens
29 FAM174A 345757
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 TMEM231 79583
Proximity Label-MS Homo sapiens
31 TRABD 80305
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 NIPAL1  
Affinity Capture-MS Homo sapiens
33 PPP6R1 22870
Affinity Capture-MS Homo sapiens
34 MARCH5  
Proximity Label-MS Homo sapiens
35 PIGH  
Affinity Capture-MS Homo sapiens
36 DNAJB1 3337
Affinity Capture-MS Homo sapiens
37 HADHA 3030
Affinity Capture-MS Homo sapiens
38 SURF1  
Proximity Label-MS Homo sapiens
39 EXD2  
Proximity Label-MS Homo sapiens
40 LACTB 114294
Co-fractionation Homo sapiens
41 DGCR2 9993
Proximity Label-MS Homo sapiens
42 SLC25A46 91137
Proximity Label-MS Homo sapiens
43 AIFM1 9131
Proximity Label-MS Homo sapiens
44 DNAJC7 7266
Affinity Capture-MS Homo sapiens
45 PDE6D 5147
Affinity Capture-MS Homo sapiens
46 PPP6R3 55291
Proximity Label-MS Homo sapiens
47 TIMM50 92609
Affinity Capture-MS Homo sapiens
48 PFDN6 10471
Affinity Capture-MS Homo sapiens
49 TUBB6 84617
Affinity Capture-MS Homo sapiens
50 RIC3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 MAD2L2 10459
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
52 KIF14 9928
Affinity Capture-MS Homo sapiens
53 TRAP1 10131
Affinity Capture-MS Homo sapiens
54 IMPDH1 3614
Affinity Capture-MS Homo sapiens
55 UNC45A 55898
Affinity Capture-MS Homo sapiens
56 APOO 79135
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
57 BAG5 9529
Affinity Capture-MS Homo sapiens
58 SHROOM3 57619
Proximity Label-MS Homo sapiens
59 ANXA7 310
Affinity Capture-MS Homo sapiens
60 MTCH2 23788
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 HS2ST1 9653
Affinity Capture-MS Homo sapiens
62 PPP5C 5536
Affinity Capture-MS Homo sapiens
63 SAMM50 25813
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
64 EMD 2010
Affinity Capture-MS Homo sapiens
65 PARK2  
Affinity Capture-MS Homo sapiens
66 MTX1 4580
Affinity Capture-MS Homo sapiens
67 CHCHD3 54927
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
68 VSIG4  
Affinity Capture-MS Homo sapiens
69 MTX2 10651
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
70 DIABLO 56616
Proximity Label-MS Homo sapiens
71 RPL18A 6142
Proximity Label-MS Homo sapiens
72 VCP 7415
Affinity Capture-MS Homo sapiens
73 NTRK1 4914
Affinity Capture-MS Homo sapiens
74 HLA-C 3107
Affinity Capture-MS Homo sapiens
75 OPA1 4976
Proximity Label-MS Homo sapiens
76 MCOLN3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
77 ARMC1 55156
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
78 UQCRC1 7384
Co-fractionation Homo sapiens
79 PML 5371
Co-fractionation Homo sapiens
80 TMEM63A 9725
Affinity Capture-MS Homo sapiens
81 RHOT2 89941
Proximity Label-MS Homo sapiens
82 TMEM171  
Affinity Capture-MS Homo sapiens
83 VDAC2 7417
Affinity Capture-MS Homo sapiens
84 ARHGAP20  
Affinity Capture-MS Homo sapiens
85 H3F3C 440093
Affinity Capture-MS Homo sapiens
86 BCOR  
Affinity Capture-MS Homo sapiens
87 UBXN6 80700
Affinity Capture-MS Homo sapiens
88 COX4I1 1327
Proximity Label-MS Homo sapiens
89 STUB1 10273
Affinity Capture-MS Homo sapiens
90 Rmdn3  
Affinity Capture-MS Mus musculus
91 TMPO 7112
Affinity Capture-MS Homo sapiens
92 APLNR  
Affinity Capture-MS Homo sapiens
93 PRICKLE3  
Affinity Capture-MS Homo sapiens
94 MINOS1  
Affinity Capture-MS Homo sapiens
Co-fractionation Homo sapiens
95 NASP 4678
Co-fractionation Homo sapiens
96 MRPS12  
Proximity Label-MS Homo sapiens
97 TAX1BP1 8887
Affinity Capture-MS Homo sapiens
98 XPO1 7514
Affinity Capture-MS Homo sapiens
99 BAG2 9532
Proximity Label-MS Homo sapiens
100 SUGT1 10910
Affinity Capture-MS Homo sapiens
101 LRRC25  
Affinity Capture-MS Homo sapiens
102 STXBP1 6812
Affinity Capture-MS Homo sapiens
103 PSMD8 5714
Proximity Label-MS Homo sapiens
104 CTNNB1 1499
Co-fractionation Homo sapiens
105 PNP 4860
Affinity Capture-MS Homo sapiens
106 GOLT1B 51026
Affinity Capture-MS Homo sapiens
107 ERGIC3 51614
Affinity Capture-MS Homo sapiens
108 P2RY2 5029
Affinity Capture-MS Homo sapiens
109 CUL3 8452
Affinity Capture-MS Homo sapiens
110 EGFR 1956
Affinity Capture-MS Homo sapiens
111 FKBP8 23770
Affinity Capture-MS Homo sapiens
112 GAA 2548
Affinity Capture-MS Homo sapiens
113 FBXO6 26270
Affinity Capture-MS Homo sapiens
114 B3GAT2  
Affinity Capture-MS Homo sapiens
115 RCN1 5954
Affinity Capture-MS Homo sapiens
116 OCIAD1 54940
Proximity Label-MS Homo sapiens
117 SYP  
Affinity Capture-MS Homo sapiens
118 FKBP5 2289
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
119 RBM26 64062
Affinity Capture-MS Homo sapiens
120 RPA3 6119
Proximity Label-MS Homo sapiens
121 APOOL 139322
Affinity Capture-MS Homo sapiens
122 COX6C 1345
Co-fractionation Homo sapiens
123 C19orf70  
Affinity Capture-MS Homo sapiens
124 RPAP3 79657
Affinity Capture-MS Homo sapiens
125 ATP1B1 481
Co-fractionation Homo sapiens
126 RCN2 5955
Affinity Capture-MS Homo sapiens
127 INPP5B 3633
Affinity Capture-MS Homo sapiens
128 HAX1  
Proximity Label-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
129 ISLR 3671
Affinity Capture-MS Homo sapiens
130 GPA33 10223
Affinity Capture-MS Homo sapiens
131 AKAP1 8165
Proximity Label-MS Homo sapiens
132 SCCPDH 51097
Co-fractionation Homo sapiens
133 SAYSD1  
Affinity Capture-MS Homo sapiens
134 CD99L2 83692
Affinity Capture-MS Homo sapiens
135 IMMT 10989
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
136 TBX3 6926
Affinity Capture-MS Homo sapiens
137 FTL 2512
Affinity Capture-MS Homo sapiens
138 CLPP 8192
Proximity Label-MS Homo sapiens
139 PLEKHA4 57664
Affinity Capture-MS Homo sapiens
140 PHB2 11331
Proximity Label-MS Homo sapiens
141 AUH 549
Co-fractionation Homo sapiens
142 H3F3A 3020
Affinity Capture-MS Homo sapiens
143 PEX19 5824
Affinity Capture-MS Homo sapiens
144 DNAJA2 10294
Affinity Capture-MS Homo sapiens
145 AKAP8  
Affinity Capture-MS Homo sapiens
146 RNF214  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
147 TOMM20 9804
Affinity Capture-MS Homo sapiens
148 NDUFS7 374291
Co-fractionation Homo sapiens
149 BMPR1A 657
Affinity Capture-MS Homo sapiens
150 C17orf62 79415
Affinity Capture-MS Homo sapiens
151 LATS1  
Proximity Label-MS Homo sapiens
152 RIT1 6016
Negative Genetic Homo sapiens
153 UFL1 23376
Affinity Capture-MS Homo sapiens
154 RBM4 5936
Affinity Capture-MS Homo sapiens
155 HDGFRP2 84717
Affinity Capture-MS Homo sapiens
156 NDUFS8 4728
Co-fractionation Homo sapiens
157 BSND  
Affinity Capture-MS Homo sapiens
158 EEF1D 1936
Co-fractionation Homo sapiens
159 C19orf52  
Proximity Label-MS Homo sapiens
160 SLC25A51  
Proximity Label-MS Homo sapiens
161 SSSCA1 10534
Affinity Capture-MS Homo sapiens
162 SPG20 23111
Affinity Capture-MS Homo sapiens
163 CAPG 822
Affinity Capture-MS Homo sapiens
164 GP5 2814
Affinity Capture-MS Homo sapiens
165 PIH1D1  
Affinity Capture-MS Homo sapiens
166 PTGES3 10728
Affinity Capture-MS Homo sapiens
167 KRAS 3845
Negative Genetic Homo sapiens
168 C9orf72  
Affinity Capture-MS Homo sapiens
169 PCDHB3  
Affinity Capture-MS Homo sapiens
170 PLD6  
Affinity Capture-MS Homo sapiens
171 ASB14  
Affinity Capture-MS Homo sapiens
172 MGST3 4259
Co-fractionation Homo sapiens
173 SUOX  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
174 COX15 1355
Proximity Label-MS Homo sapiens
175 NUCB1 4924
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which DNAJC11 is involved
PathwayEvidenceSource
Cristae formation IEA Reactome
Mitochondrial biogenesis IEA Reactome
Organelle biogenesis and maintenance IEA Reactome





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