Gene description for PPTC7
Gene name PTC7 protein phosphatase homolog (S. cerevisiae)
Gene symbol PPTC7
Other names/aliases TA-PP2C
TAPP2C
Species Homo sapiens
 Database cross references - PPTC7
ExoCarta ExoCarta_160760
Vesiclepedia VP_160760
Entrez Gene 160760
HGNC 30695
MIM 609668
UniProt Q8NI37  
 PPTC7 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
 Gene ontology annotations for PPTC7
Molecular Function
    protein serine/threonine phosphatase activity GO:0004722 IBA
    protein serine/threonine phosphatase activity GO:0004722 IMP
    protein binding GO:0005515 IPI
    myosin phosphatase activity GO:0017018 IEA
    calmodulin-dependent protein phosphatase activity GO:0033192 IEA
    metal ion binding GO:0046872 IEA
    histone H2AXS140 phosphatase activity GO:0140791 IEA
    RNA polymerase II CTD heptapeptide repeat Y1 phosphatase activity GO:0180004 IEA
    RNA polymerase II CTD heptapeptide repeat T4 phosphatase activity GO:0180005 IEA
    RNA polymerase II CTD heptapeptide repeat S2 phosphatase activity GO:0180006 IEA
    RNA polymerase II CTD heptapeptide repeat S5 phosphatase activity GO:0180007 IEA
    RNA polymerase II CTD heptapeptide repeat S7 phosphatase activity GO:0180008 IEA
    MAP kinase serine/threonine phosphatase activity GO:1990439 IEA
Biological Process
    chromatin remodeling GO:0006338 IEA
    regulation of transcription by RNA polymerase II GO:0006357 IEA
    regulation of ubiquinone biosynthetic process GO:0010795 IBA
    regulation of ubiquinone biosynthetic process GO:0010795 IMP
    peptidyl-serine dephosphorylation GO:0070262 IMP
Subcellular Localization
    mitochondrion GO:0005739 HTP
    mitochondrion GO:0005739 IBA
    mitochondrial matrix GO:0005759 IMP
 Experiment description of studies that identified PPTC7 in exosomes
1
Experiment ID 489
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
✔
EM
Biophysical techniques
✔
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
✔
Canx
Negative markers
✔
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ.
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PPTC7
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 PA2G4 5036
Affinity Capture-MS Homo sapiens
2 RHOT1 55288
Affinity Capture-MS Homo sapiens
3 HIST1H4I 8294
Affinity Capture-MS Homo sapiens
4 ACSF2 80221
Affinity Capture-MS Homo sapiens
5 CSTL1  
Affinity Capture-MS Homo sapiens
6 HIST1H4K 8362
Affinity Capture-MS Homo sapiens
7 PRDX6 9588
Affinity Capture-MS Homo sapiens
8 AGPAT5 55326
Affinity Capture-MS Homo sapiens
9 ASF1A 25842
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
10 TMEM9 252839
Affinity Capture-MS Homo sapiens
11 SARS2 54938
Affinity Capture-MS Homo sapiens
12 ABCB6 10058
Affinity Capture-MS Homo sapiens
13 AIFM1 9131
Affinity Capture-MS Homo sapiens
14 HMGB1 3146
Affinity Capture-MS Homo sapiens
15 SSR2  
Affinity Capture-MS Homo sapiens
16 TRMT61B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
17 YWHAB 7529
Affinity Capture-MS Homo sapiens
18 ASF1B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
19 S100A6 6277
Affinity Capture-MS Homo sapiens
20 OSTM1 28962
Affinity Capture-MS Homo sapiens
21 ZDHHC17 23390
Two-hybrid Homo sapiens
22 NME2 4831
Affinity Capture-MS Homo sapiens
23 CD70 970
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
24 UCHL1 7345
Affinity Capture-MS Homo sapiens
25 CALR 811
Affinity Capture-MS Homo sapiens
26 SLC7A11 23657
Affinity Capture-MS Homo sapiens
27 HIST1H4A 8359
Affinity Capture-MS Homo sapiens
28 HS3ST4  
Affinity Capture-MS Homo sapiens
29 LAMP2 3920
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
30 ELAVL1 1994
Affinity Capture-RNA Homo sapiens
31 UBB 7314
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
32 TRABD 80305
Affinity Capture-MS Homo sapiens
33 H3F3B 3021
Affinity Capture-MS Homo sapiens
34 PARK7 11315
Affinity Capture-MS Homo sapiens
35 RBBP4 5928
Affinity Capture-MS Homo sapiens
36 MYO1C 4641
Affinity Capture-MS Homo sapiens
37 GPR150  
Affinity Capture-MS Homo sapiens
38 MRPS18C  
Affinity Capture-MS Homo sapiens
39 SPHKAP  
Affinity Capture-MS Homo sapiens
40 PPTC7 160760
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
41 HIST1H4B 8366
Affinity Capture-MS Homo sapiens
42 TPM4 7171
Affinity Capture-MS Homo sapiens
43 MAOB  
Affinity Capture-MS Homo sapiens
44 HIST1H4L 8368
Affinity Capture-MS Homo sapiens
45 PGK1 5230
Affinity Capture-MS Homo sapiens
46 BRICD5  
Affinity Capture-MS Homo sapiens
47 PBXIP1 57326
Two-hybrid Homo sapiens
48 HIST1H4C 8364
Affinity Capture-MS Homo sapiens
49 CLPB 81570
Affinity Capture-MS Homo sapiens
50 DBT 1629
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 GPR45  
Affinity Capture-MS Homo sapiens
52 RTN4IP1  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
53 TRMT2B  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
54 DNAJC11 55735
Affinity Capture-MS Homo sapiens
55 FAM174A 345757
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
56 HIST1H4F 8361
Affinity Capture-MS Homo sapiens
57 C1QBP 708
Affinity Capture-MS Homo sapiens
58 LDLR 3949
Negative Genetic Homo sapiens
59 EIF5A 1984
Affinity Capture-MS Homo sapiens
60 LPAR4  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
61 GNB2L1 10399
Affinity Capture-MS Homo sapiens
62 BNIP3 664
Affinity Capture-MS Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
63 BCL6  
Two-hybrid Homo sapiens
64 MRPL22  
Affinity Capture-MS Homo sapiens
65 BNIP3L  
Affinity Capture-MS Homo sapiens
66 RHOT2 89941
Affinity Capture-MS Homo sapiens
67 GPAT2  
Affinity Capture-MS Homo sapiens
68 HSDL1 83693
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
69 UBA1 7317
Affinity Capture-MS Homo sapiens
70 CKB 1152
Affinity Capture-MS Homo sapiens
71 GGT7 2686
Affinity Capture-MS Homo sapiens
72 GPI 2821
Affinity Capture-MS Homo sapiens
73 GNB2 2783
Affinity Capture-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PPTC7 is involved
No pathways found





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