Gene description for PBXIP1
Gene name pre-B-cell leukemia homeobox interacting protein 1
Gene symbol PBXIP1
Other names/aliases HPIP
Species Homo sapiens
 Database cross references - PBXIP1
ExoCarta ExoCarta_57326
Vesiclepedia VP_57326
Entrez Gene 57326
HGNC 21199
UniProt Q96AQ6  
 PBXIP1 identified in exosomes derived from the following tissue/cell type
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Bone marrow mesenchymal stem cells 36408942    
Mesenchymal stem cells 36408942    
 Gene ontology annotations for PBXIP1
Molecular Function
    transcription coregulator activity GO:0003712 IBA
    transcription coactivator activity GO:0003713 IEA
    transcription corepressor activity GO:0003714 IDA
    protein binding GO:0005515 IPI
    DNA-binding transcription factor binding GO:0140297 IPI
Biological Process
    production of molecular mediator involved in inflammatory response GO:0002532 IEA
    regulation of DNA-templated transcription GO:0006355 IBA
    cell adhesion GO:0007155 IEA
    cell migration GO:0016477 IEA
    extracellular matrix disassembly GO:0022617 IEA
    hemopoiesis GO:0030097 IEP
    positive regulation of Wnt signaling pathway GO:0030177 IEA
    negative regulation of DNA-templated transcription GO:0045892 IDA
    positive regulation of DNA-templated transcription GO:0045893 IEA
    articular cartilage development GO:0061975 IEA
    gene expression involved in extracellular matrix organization GO:1901148 IEA
    positive regulation of chondrocyte proliferation GO:1902732 IEA
Subcellular Localization
    chromatin GO:0000785 IEA
    nucleus GO:0005634 IBA
    nucleus GO:0005634 IDA
    nucleoplasm GO:0005654 IDA
    transcription regulator complex GO:0005667 IEA
    cytosol GO:0005829 IDA
    microtubule GO:0005874 IEA
 Experiment description of studies that identified PBXIP1 in exosomes
1
Experiment ID 489
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 6
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
2
Experiment ID 490
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 7
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
3
Experiment ID 491
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 8
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
4
Experiment ID 492
MISEV standards
EM
Biophysical techniques
Cd9|Cd81|Cd63|Gapdh|Sdcbp|Lamp1|Aqp1|Rab5a|Icam1|Cd82|Itga2b|Tsg101|Lamp2|Rab35|Flot1|Flot2|Cd151|Rab5b|Tfrc|Uchl1
Enriched markers
Canx
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Rattus norvegicus
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Bone marrow mesenchymal stem cells
Sample name BMSC - Passage 9
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
5
Experiment ID 488
MISEV standards
EM
Biophysical techniques
CD9|CD81|CD63|GAPDH|SDCBP|LAMP1|TFRC|UCHL1|FLOT2|LAMP2|FLOT1|ICAM1|RAB5B|CD151|RAB35|TSG101|RAB5A|CD82
Enriched markers
CANX
Negative markers
NTA
Particle analysis
Identified molecule Protein
Identification method Mass spectrometry
PubMed ID 36408942    
Organism Homo sapiens
Experiment description Quantitative proteomic analysis of exosomes from umbilical cord mesenchymal stem cells and rat bone marrow stem cells
Authors "Xu X, Yin F, Guo M, Gan G, Lin G, Wen C, Wang J, Song P, Wang J, Qi ZQ, Zhong CQ."
Journal name Proteomics
Publication year 2023
Sample Mesenchymal stem cells
Sample name UCMSC
Isolation/purification methods Differential centrifugation
Filtration
Ultracentrifugation
Flotation density -
Molecules identified in the study Protein
Methods used in the study Western blotting
Mass spectometry
 Protein-protein interactions for PBXIP1
  Protein Interactor ExoCarta ID Identification method PubMed Species
1 TACR3  
Affinity Capture-MS Homo sapiens
2 SGTA 6449
Two-hybrid Homo sapiens
3 GABARAPL1 23710
Two-hybrid Homo sapiens
4 ST8SIA3  
Affinity Capture-MS Homo sapiens
5 HSD17B11 51170
Proximity Label-MS Homo sapiens
6 EPHX4 253152
Affinity Capture-MS Homo sapiens
7 FUT8 2530
Affinity Capture-MS Homo sapiens
8 ATR  
Affinity Capture-MS Homo sapiens
9 KLK15  
Affinity Capture-MS Homo sapiens
10 ZMYND8 23613
Two-hybrid Homo sapiens
11 VTI1B 10490
Affinity Capture-MS Homo sapiens
12 DPY19L1 23333
Affinity Capture-MS Homo sapiens
13 DEF6 50619
Two-hybrid Homo sapiens
14 METTL7A 25840
Proximity Label-MS Homo sapiens
15 HLA-E 3133
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
16 C3orf58 205428
Affinity Capture-MS Homo sapiens
17 ATP13A2  
Affinity Capture-MS Homo sapiens
18 DPY19L3  
Affinity Capture-MS Homo sapiens
19 CFC1  
Affinity Capture-MS Homo sapiens
20 TMEM206 55248
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
21 MFAP4 4239
Affinity Capture-MS Homo sapiens
22 ECEL1  
Affinity Capture-MS Homo sapiens
23 ZZZ3  
Two-hybrid Homo sapiens
24 DNAJC25 548645
Proximity Label-MS Homo sapiens
25 SLC27A4 10999
Affinity Capture-MS Homo sapiens
26 CLEC12A  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
27 PNKD  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
28 FAM20B 9917
Affinity Capture-MS Homo sapiens
29 ABCD1 215
Affinity Capture-MS Homo sapiens
30 PPTC7 160760
Two-hybrid Homo sapiens
31 B3GNT2 10678
Affinity Capture-MS Homo sapiens
32 KRTAP10-6  
Two-hybrid Homo sapiens
33 SCARA3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
34 TSNAX 7257
Two-hybrid Homo sapiens
35 RRP12 23223
Affinity Capture-MS Homo sapiens
36 CCDC138  
Affinity Capture-MS Homo sapiens
37 STX8 9482
Affinity Capture-MS Homo sapiens
38 CLEC2B  
Affinity Capture-MS Homo sapiens
39 SDF2L1 23753
Affinity Capture-MS Homo sapiens
40 CCDC53 51019
Two-hybrid Homo sapiens
41 SSR1 6745
Proximity Label-MS Homo sapiens
42 ENTPD2 954
Affinity Capture-MS Homo sapiens
43 UBQLN1 29979
Two-hybrid Homo sapiens
44 EPHA1 2041
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
45 STX6 10228
Affinity Capture-MS Homo sapiens
46 HKDC1 80201
Affinity Capture-MS Homo sapiens
47 ABCD3 5825
Affinity Capture-MS Homo sapiens
48 BCAP29 55973
Affinity Capture-MS Homo sapiens
49 UTP20 27340
Affinity Capture-MS Homo sapiens
50 B3GAT3 26229
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
51 MECP2 4204
Affinity Capture-MS Homo sapiens
52 ARFGEF2 10564
Affinity Capture-MS Homo sapiens
53 TMEM106A  
Affinity Capture-MS Homo sapiens
54 UBQLN4 56893
Two-hybrid Homo sapiens
55 CTU1 90353
Affinity Capture-MS Homo sapiens
56 SACM1L 22908
Affinity Capture-MS Homo sapiens
57 KIF14 9928
Affinity Capture-MS Homo sapiens
58 FAS 355
Proximity Label-MS Homo sapiens
59 CAMLG 819
Two-hybrid Homo sapiens
60 ZFPL1 7542
Affinity Capture-MS Homo sapiens
61 GOLIM4 27333
Affinity Capture-MS Homo sapiens
62 PTGES2 80142
Affinity Capture-MS Homo sapiens
63 BRPF1  
Two-hybrid Homo sapiens
64 ATAD3B 83858
Affinity Capture-MS Homo sapiens
65 BRINP1  
Affinity Capture-MS Homo sapiens
66 TBK1 29110
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Affinity Capture-Western Homo sapiens
67 EXOG 9941
Affinity Capture-MS Homo sapiens
68 CYB5D2  
Affinity Capture-MS Homo sapiens
69 TAB3 257397
Affinity Capture-Western Homo sapiens
70 NBN 4683
Affinity Capture-MS Homo sapiens
71 DPPA2  
Two-hybrid Homo sapiens
72 COMTD1 118881
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
73 GRAMD4 23151
Affinity Capture-MS Homo sapiens
74 KIDINS220 57498
Affinity Capture-MS Homo sapiens
75 FIBIN  
Affinity Capture-MS Homo sapiens
76 ATP9A 10079
Affinity Capture-MS Homo sapiens
77 NTRK1 4914
Affinity Capture-MS Homo sapiens
78 LEMD2 221496
Affinity Capture-MS Homo sapiens
79 TAPT1 202018
Affinity Capture-MS Homo sapiens
80 ITM2C 81618
Affinity Capture-MS Homo sapiens
81 DNAJB9 4189
Affinity Capture-MS Homo sapiens
82 FIGF 2277
Affinity Capture-MS Homo sapiens
83 CDHR4  
Affinity Capture-MS Homo sapiens
84 ARRDC3 57561
Affinity Capture-MS Homo sapiens
85 SLC25A17 10478
Affinity Capture-MS Homo sapiens
86 RPN1 6184
Proximity Label-MS Homo sapiens
87 SLC27A1 376497
Affinity Capture-MS Homo sapiens
88 CUX1 1523
Affinity Capture-MS Homo sapiens
89 UQCRH 7388
Affinity Capture-MS Homo sapiens
90 XYLT2 64132
Affinity Capture-MS Homo sapiens
91 ELOVL5 60481
Proximity Label-MS Homo sapiens
92 SEC61B 10952
Proximity Label-MS Homo sapiens
93 MAN2A2 4122
Affinity Capture-MS Homo sapiens
94 DAXX  
Two-hybrid Homo sapiens
95 TXNDC11 51061
Affinity Capture-MS Homo sapiens
96 RMDN3 55177
Affinity Capture-MS Homo sapiens
97 REEP5 7905
Proximity Label-MS Homo sapiens
98 CLEC4F  
Affinity Capture-MS Homo sapiens
99 TTI1 9675
Affinity Capture-MS Homo sapiens
100 GPIHBP1  
Affinity Capture-MS Homo sapiens
101 BCAP31 10134
Proximity Label-MS Homo sapiens
102 MYO10 4651
Affinity Capture-MS Homo sapiens
103 CDK19 23097
Affinity Capture-MS Homo sapiens
104 RDH14 57665
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
105 RPN2 6185
Proximity Label-MS Homo sapiens
106 MDFI  
Two-hybrid Homo sapiens
107 CANX 821
Affinity Capture-MS Homo sapiens
108 TARBP1 6894
Affinity Capture-MS Homo sapiens
109 CCNC  
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
110 BTNL9  
Affinity Capture-MS Homo sapiens
111 TMEM39B  
Affinity Capture-MS Homo sapiens
112 LRRC59 55379
Proximity Label-MS Homo sapiens
113 FAM57A  
Affinity Capture-MS Homo sapiens
114 LCA5L  
Two-hybrid Homo sapiens
115 GGH 8836
Affinity Capture-MS Homo sapiens
116 PRKAA2 5563
Two-hybrid Homo sapiens
117 PRG2  
Affinity Capture-MS Homo sapiens
118 HSD3B7 80270
Proximity Label-MS Homo sapiens
119 PI15  
Affinity Capture-MS Homo sapiens
120 STIM1 6786
Affinity Capture-MS Homo sapiens
121 CBLN4  
Affinity Capture-MS Homo sapiens
122 MYO5A 4644
Affinity Capture-MS Homo sapiens
123 XRCC6BP1  
Affinity Capture-MS Homo sapiens
124 OMA1  
Affinity Capture-MS Homo sapiens
125 MORF4L1  
Two-hybrid Homo sapiens
126 IL5RA  
Affinity Capture-MS Homo sapiens
127 PIGW  
Affinity Capture-MS Homo sapiens
128 CCDC127  
Affinity Capture-MS Homo sapiens
129 CHRNA9  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
130 MYO1D 4642
Affinity Capture-MS Homo sapiens
131 YME1L1 10730
Affinity Capture-MS Homo sapiens
132 TAOK2 9344
Affinity Capture-MS Homo sapiens
133 GPR45  
Affinity Capture-MS Homo sapiens
134 CCDC85B  
Two-hybrid Homo sapiens
135 KCNN4 3783
Affinity Capture-MS Homo sapiens
136 P2RX5 5026
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
137 LETMD1  
Affinity Capture-MS Homo sapiens
138 RNF2  
Affinity Capture-MS Homo sapiens
139 MPPE1 65258
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
140 GMCL1  
Two-hybrid Homo sapiens
Two-hybrid Homo sapiens
Affinity Capture-MS Homo sapiens
141 GHITM 27069
Affinity Capture-MS Homo sapiens
142 SEPN1 57190
Affinity Capture-MS Homo sapiens
143 MDM2  
Biochemical Activity Homo sapiens
Affinity Capture-Western Homo sapiens
144 PRKDC 5591
Affinity Capture-MS Homo sapiens
145 CTU2 348180
Affinity Capture-MS Homo sapiens
146 HTATSF1 27336
Affinity Capture-MS Homo sapiens
147 ADAM30 11085
Affinity Capture-MS Homo sapiens
148 TANK 10010
Affinity Capture-Western Homo sapiens
149 MUL1  
Affinity Capture-MS Homo sapiens
150 PCBD2 84105
Two-hybrid Homo sapiens
151 HLA-G 3135
Affinity Capture-MS Homo sapiens
152 TMEM57  
Affinity Capture-MS Homo sapiens
153 GRB2 2885
Two-hybrid Homo sapiens
154 CDK8 1024
Affinity Capture-MS Homo sapiens
155 UQCC1 55245
Affinity Capture-MS Homo sapiens
156 HLA-DRA 3122
Affinity Capture-MS Homo sapiens
157 B3GALT6 126792
Affinity Capture-MS Homo sapiens
158 XPR1 9213
Affinity Capture-MS Homo sapiens
159 TNFSF14  
Affinity Capture-MS Homo sapiens
160 IKBKG 8517
Affinity Capture-Western Homo sapiens
161 SLC35B2 347734
Affinity Capture-MS Homo sapiens
162 CD1A 909
Affinity Capture-MS Homo sapiens
163 UNC93B1 81622
Affinity Capture-MS Homo sapiens
164 MGAT4C  
Affinity Capture-MS Homo sapiens
165 NCR3  
Affinity Capture-MS Homo sapiens
166 DDX58 23586
Affinity Capture-RNA Homo sapiens
167 PTGER3  
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
Affinity Capture-MS Homo sapiens
168 EDEM3 80267
Affinity Capture-MS Homo sapiens
169 EDEM2  
Affinity Capture-MS Homo sapiens
170 ESR1  
Two-hybrid Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
Affinity Capture-Western Homo sapiens
Reconstituted Complex Homo sapiens
171 CHRM3 1131
Affinity Capture-MS Homo sapiens
172 CLEC12B  
Affinity Capture-MS Homo sapiens
173 DUOX1  
Affinity Capture-MS Homo sapiens
174 NOC2L 26155
Affinity Capture-MS Homo sapiens
175 SPN 6693
Affinity Capture-MS Homo sapiens
176 SEC62 7095
Proximity Label-MS Homo sapiens
177 FAM69A 388650
Affinity Capture-MS Homo sapiens
178 ALG8  
Affinity Capture-MS Homo sapiens
179 UGT1A7 54577
Affinity Capture-MS Homo sapiens
180 ACSL3 2181
Affinity Capture-MS Homo sapiens
181 TMEM38B  
Affinity Capture-MS Homo sapiens
182 LPAR2 9170
Affinity Capture-MS Homo sapiens
183 CST11  
Affinity Capture-MS Homo sapiens
184 CISD2 493856
Affinity Capture-MS Homo sapiens
185 DNAJC1 64215
Proximity Label-MS Homo sapiens
186 CMSS1  
Affinity Capture-MS Homo sapiens
187 WFS1 7466
Affinity Capture-MS Homo sapiens
188 PLD6  
Affinity Capture-MS Homo sapiens
189 DERL1 79139
Proximity Label-MS Homo sapiens
View the network image/svg+xml
 Pathways in which PBXIP1 is involved
No pathways found





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